Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent

To evaluate the effect of the 4G/5G PAI-1 gene polymorphism on the development of organ failure and outcome in critically ill patients with septic syndromes. Prospective, observational study in a medical intensive care unit of a university hospital. 224 consecutively admitted patients. Epidemiologic...

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Veröffentlicht in:	Intensive care medicine 2007-08, Vol.33 (8), p.1354-1362
Hauptverfasser:	GARCIA-SEGARRA, Gloria, ESPINOSA, Gerard, TASSIES, Dolors, ORIOLA, Josep, AIBAR, Jesus, BOVE, Albert, CASTRO, Pedro, REVERTER, Joan-Caries, NICOLAS, Josep-Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Blood. Blood coagulation. Reticuloendothelial system Deoxyribonucleic acid Dimers DNA Epidemiology Failure Female Gene polymorphism Genotype & phenotype Genotypes Genotyping Homozygosity Homozygotes Hospital Mortality Hospitals Humans Infections Inflammation Inflammatory response Intensive care Intensive care medicine Intensive Care Units Interleukin 1 Male Medical Records Medical sciences Middle Aged Mortality Multiple Organ Failure - genetics Nosocomial infection Patients Pharmacology. Drug treatments Physiology Plasminogen Activator Inhibitor 1 - genetics Plasminogen activator inhibitors Polymorphism Polymorphism, Genetic Sepsis Septic shock Shock, Septic - genetics Shock, Septic - mortality Spain Systemic inflammatory response syndrome Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor necrosis factor Tumor necrosis factor-TNF Whites - genetics
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