A Memory of Chirality Approach to the Stereoselective Synthesis of 4-Hydroxy-α-methylprolines

To extend the memory of chirality (MOC) methodology to structurally more diverse compounds, the synthesis of 4-hydroxy-α-methylprolines was undertaken. Yield and selectivity were very good, with an unexpected reversal in selectivity observed for the cyclization of one adduct with an unprotected hydr...

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Veröffentlicht in:	Organic letters 2007-08, Vol.9 (16), p.3029-3032
Hauptverfasser:	Kolaczkowski, Lawrence, Barnes, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Cyclization Molecular Structure Proline - analogs & derivatives Proline - chemical synthesis Proline - chemistry Stereoisomerism
Online-Zugang:	Volltext
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