Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts

ABSTRACT Protein misfolding and aberrant aggregation are associated with many severe disorders, such as neural degenerative diseases, desmin‐related myopathy (DRM), and congestive heart failure. Intrasarcoplasmic amyloidosis and increased ubiquitinated proteins are observed in human failing hearts....

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Veröffentlicht in:	The FASEB journal 2006-02, Vol.20 (2), p.362-364
Hauptverfasser:	Liu, Jinbao, Chen, Quanhai, Huang, Wei, Horak, Kathleen M, Zheng, Hanqiao, Mestril, Ruben, Wang, Xuejun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Desmin - genetics Desmin - metabolism desmin‐related cardiomyopathy green fluorescence protein Humans Mice Muscular Diseases - enzymology Muscular Diseases - metabolism Muscular Diseases - pathology Myocardium - enzymology Myocardium - pathology peptidases Proteasome Endopeptidase Complex - metabolism protein aggregation Protein Folding transgenic Ubiquitin - metabolism
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