MafB : An activator of the glucagon gene expressed in developing islet α- and β-cells
The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various cell types, including pancreatic islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and co...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2006-02, Vol.55 (2), p.297-304 |
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| container_title | Diabetes (New York, N.Y.) |
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| creator | ARTNER, Isabella LE LAY, John YAN HANG ELGHAZI, Lynda SCHISLER, Jonathan C HENDERSON, Eva SOSA-PINEDA, Beatriz STEIN, Roland |
| description | The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various cell types, including pancreatic islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene through activation of a conserved control element found between nucleotides -77 to -51. MafB was also shown to be expressed in developing alpha- and beta-cells as well as in proliferating hormone-negative cells during pancreatogenesis. In addition, MafB expression is maintained in the insulin(+) and glucagon(+) cells remaining in mice lacking either the Pax4 or Pax6 developmental regulators, implicating a potentially early role for MafB in gene regulation during islet cell development. These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation. |
| doi_str_mv | 10.2337/diabetes.55.02.06.db05-0946 |
| format | Article |
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Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene through activation of a conserved control element found between nucleotides -77 to -51. MafB was also shown to be expressed in developing alpha- and beta-cells as well as in proliferating hormone-negative cells during pancreatogenesis. In addition, MafB expression is maintained in the insulin(+) and glucagon(+) cells remaining in mice lacking either the Pax4 or Pax6 developmental regulators, implicating a potentially early role for MafB in gene regulation during islet cell development. These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/diabetes.55.02.06.db05-0946</identifier><identifier>PMID: 16443760</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Animals ; Biological and medical sciences ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eye Proteins - genetics ; Eye Proteins - metabolism ; Gene Deletion ; Gene expression ; Gene Expression Regulation, Developmental ; Glucagon - genetics ; Glucagon - metabolism ; Glucagon-Secreting Cells - cytology ; Glucagon-Secreting Cells - metabolism ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Insulin-Secreting Cells - cytology ; Insulin-Secreting Cells - metabolism ; MafB Transcription Factor - genetics ; MafB Transcription Factor - metabolism ; Medical sciences ; Mice ; Oncogene Proteins - genetics ; Oncogene Proteins - metabolism ; Paired Box Transcription Factors - genetics ; Paired Box Transcription Factors - metabolism ; Pancreatic beta cells ; PAX6 Transcription Factor ; Promoter Regions, Genetic ; Repressor Proteins - genetics ; Repressor Proteins - metabolism</subject><ispartof>Diabetes (New York, N.Y.), 2006-02, Vol.55 (2), p.297-304</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 American Diabetes Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17483349$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16443760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARTNER, Isabella</creatorcontrib><creatorcontrib>LE LAY, John</creatorcontrib><creatorcontrib>YAN HANG</creatorcontrib><creatorcontrib>ELGHAZI, Lynda</creatorcontrib><creatorcontrib>SCHISLER, Jonathan C</creatorcontrib><creatorcontrib>HENDERSON, Eva</creatorcontrib><creatorcontrib>SOSA-PINEDA, Beatriz</creatorcontrib><creatorcontrib>STEIN, Roland</creatorcontrib><title>MafB : An activator of the glucagon gene expressed in developing islet α- and β-cells</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various cell types, including pancreatic islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene through activation of a conserved control element found between nucleotides -77 to -51. MafB was also shown to be expressed in developing alpha- and beta-cells as well as in proliferating hormone-negative cells during pancreatogenesis. In addition, MafB expression is maintained in the insulin(+) and glucagon(+) cells remaining in mice lacking either the Pax4 or Pax6 developmental regulators, implicating a potentially early role for MafB in gene regulation during islet cell development. These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Eye Proteins - genetics</subject><subject>Eye Proteins - metabolism</subject><subject>Gene Deletion</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Glucagon - genetics</subject><subject>Glucagon - metabolism</subject><subject>Glucagon-Secreting Cells - cytology</subject><subject>Glucagon-Secreting Cells - metabolism</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Insulin-Secreting Cells - cytology</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>MafB Transcription Factor - genetics</subject><subject>MafB Transcription Factor - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Oncogene Proteins - genetics</subject><subject>Oncogene Proteins - metabolism</subject><subject>Paired Box Transcription Factors - genetics</subject><subject>Paired Box Transcription Factors - metabolism</subject><subject>Pancreatic beta cells</subject><subject>PAX6 Transcription Factor</subject><subject>Promoter Regions, Genetic</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d1q1UAQAOBFLPZYfQVZEAUvEmezv_HutNhaOOKNondhs5mNKzmbY3ZT6mPZB-kzmdJTSqEgczEwfDMMM4S8ZlBWnOv3XbAtZkyllCVUJaiya0EWUAv1hKxYzeuCV_rHU7ICYFXBdK0PyfOUfgGAWuIZOWRKCK4VrMj3z9Yf0w90Hal1OVzYPE509DT_RNoPs7P9GGmPESle7iZMCTsaIu3wAodxF2JPQxow0-u_BbWxo9dXhcNhSC_IgbdDwpf7fES-nX78evKp2Hw5Oz9Zb4qeM5YLb1oBrahrrTxIECiVcloaNFaBluiEMm1lPLToqwoQOlMbYVonaucFAj8ib2_n7qbx94wpN9uQbjawEcc5NRo0N1JX_4VMCwVCigUWt7C3AzYh-jFP1t2cYLLDGNGHpbxmomISJNeLLx_xS3S4De7RhncPGhaT8TL3dk6pMWebh_bVfuu53WLX7KawtdOf5u6BC3izBzY5O_jJRhfSvdPCcC5q_g8_C6t_</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>ARTNER, Isabella</creator><creator>LE LAY, John</creator><creator>YAN HANG</creator><creator>ELGHAZI, Lynda</creator><creator>SCHISLER, Jonathan C</creator><creator>HENDERSON, Eva</creator><creator>SOSA-PINEDA, Beatriz</creator><creator>STEIN, Roland</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>MafB : An activator of the glucagon gene expressed in developing islet α- and β-cells</title><author>ARTNER, Isabella ; LE LAY, John ; YAN HANG ; ELGHAZI, Lynda ; SCHISLER, Jonathan C ; HENDERSON, Eva ; SOSA-PINEDA, Beatriz ; STEIN, Roland</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g311t-f8b40b49976f0504e566c758e8a6075ec468b28f0bef220e0d89848bc49cf4e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Eye Proteins - genetics</topic><topic>Eye Proteins - metabolism</topic><topic>Gene Deletion</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Glucagon - genetics</topic><topic>Glucagon - metabolism</topic><topic>Glucagon-Secreting Cells - cytology</topic><topic>Glucagon-Secreting Cells - metabolism</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Insulin-Secreting Cells - cytology</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>MafB Transcription Factor - genetics</topic><topic>MafB Transcription Factor - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Oncogene Proteins - genetics</topic><topic>Oncogene Proteins - metabolism</topic><topic>Paired Box Transcription Factors - genetics</topic><topic>Paired Box Transcription Factors - metabolism</topic><topic>Pancreatic beta cells</topic><topic>PAX6 Transcription Factor</topic><topic>Promoter Regions, Genetic</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARTNER, Isabella</creatorcontrib><creatorcontrib>LE LAY, John</creatorcontrib><creatorcontrib>YAN HANG</creatorcontrib><creatorcontrib>ELGHAZI, Lynda</creatorcontrib><creatorcontrib>SCHISLER, Jonathan C</creatorcontrib><creatorcontrib>HENDERSON, Eva</creatorcontrib><creatorcontrib>SOSA-PINEDA, Beatriz</creatorcontrib><creatorcontrib>STEIN, Roland</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: High School</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARTNER, Isabella</au><au>LE LAY, John</au><au>YAN HANG</au><au>ELGHAZI, Lynda</au><au>SCHISLER, Jonathan C</au><au>HENDERSON, Eva</au><au>SOSA-PINEDA, Beatriz</au><au>STEIN, Roland</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MafB : An activator of the glucagon gene expressed in developing islet α- and β-cells</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>55</volume><issue>2</issue><spage>297</spage><epage>304</epage><pages>297-304</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various cell types, including pancreatic islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene through activation of a conserved control element found between nucleotides -77 to -51. MafB was also shown to be expressed in developing alpha- and beta-cells as well as in proliferating hormone-negative cells during pancreatogenesis. In addition, MafB expression is maintained in the insulin(+) and glucagon(+) cells remaining in mice lacking either the Pax4 or Pax6 developmental regulators, implicating a potentially early role for MafB in gene regulation during islet cell development. These results indicate that MafB is not only important to islet alpha-cell function but may also be involved in regulating genes required in both endocrine alpha- and beta-cell differentiation.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>16443760</pmid><doi>10.2337/diabetes.55.02.06.db05-0946</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biological and medical sciences Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye Proteins - genetics Eye Proteins - metabolism Gene Deletion Gene expression Gene Expression Regulation, Developmental Glucagon - genetics Glucagon - metabolism Glucagon-Secreting Cells - cytology Glucagon-Secreting Cells - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism MafB Transcription Factor - genetics MafB Transcription Factor - metabolism Medical sciences Mice Oncogene Proteins - genetics Oncogene Proteins - metabolism Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pancreatic beta cells PAX6 Transcription Factor Promoter Regions, Genetic Repressor Proteins - genetics Repressor Proteins - metabolism |
| title | MafB : An activator of the glucagon gene expressed in developing islet α- and β-cells |
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