Carvedilol Increases Copper‐Zinc Superoxide Dismutase Activity in Patients with Acute Myocardial Infarction
: Balanced and coordinated antioxidant defence enzyme activities are of utmost importance for correct physiological function and for shielding against unwelcome pathological conditions. We determined the activities of copper‐zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and...
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| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2007-08, Vol.101 (2), p.138-142 |
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| creator | Kastratović, Dragana A. Vasiljević, Zorana M. Spasić, Mihajlo B. Perunicić, Jovan P. Matić, Mihajlo Blagojević, Dusko P. Mijalković, Dejan N. Antonijević, Nebojsa M. Marković, Srdjan Z. Gojković‐Bukarica, Ljiljana Stojiljkovic, Milos P. Lasica, Ratko M. Jones, David R. Nikolić‐Kokić, Aleksandra L. |
| description | : Balanced and coordinated antioxidant defence enzyme activities are of utmost importance for correct physiological function and for shielding against unwelcome pathological conditions. We determined the activities of copper‐zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and glutathione reductase in erythrocytes isolated from patients receiving different therapy (streptokinase alone or in combination with metoprolol or with carvedilol) for up to 168 hr after starting treatment for acute myocardial infarction. We observed increased CuZnSOD activity in erythrocytes isolated from patients treated with streptokinase‐carvedilol (after 6, 24 and 168 hr) and in erythrocytes isolated from patients treated with streptokinase‐metoprolol (after 24 hr). In addition, positive correlation between CuZnSOD and catalase activities was found in erythrocytes isolated from patients that received streptokinase‐carvedilol after 168 hr. As metoprolol does not react directly with hydrogen peroxide, it would appear that combined streptokinase‐metoprolol therapy exerted its effects primarily via by β‐blockade whereas combined streptokinase‐carvedilol therapy appeared to function via both β‐blockade and direct antioxidant mechanisms. |
| doi_str_mv | 10.1111/j.1742-7843.2007.00094.x |
| format | Article |
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We determined the activities of copper‐zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and glutathione reductase in erythrocytes isolated from patients receiving different therapy (streptokinase alone or in combination with metoprolol or with carvedilol) for up to 168 hr after starting treatment for acute myocardial infarction. We observed increased CuZnSOD activity in erythrocytes isolated from patients treated with streptokinase‐carvedilol (after 6, 24 and 168 hr) and in erythrocytes isolated from patients treated with streptokinase‐metoprolol (after 24 hr). In addition, positive correlation between CuZnSOD and catalase activities was found in erythrocytes isolated from patients that received streptokinase‐carvedilol after 168 hr. As metoprolol does not react directly with hydrogen peroxide, it would appear that combined streptokinase‐metoprolol therapy exerted its effects primarily via by β‐blockade whereas combined streptokinase‐carvedilol therapy appeared to function via both β‐blockade and direct antioxidant mechanisms.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/j.1742-7843.2007.00094.x</identifier><identifier>PMID: 17651317</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adrenergic Antagonists - therapeutic use ; Biological and medical sciences ; Carbazoles - therapeutic use ; Cardiology. 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We determined the activities of copper‐zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and glutathione reductase in erythrocytes isolated from patients receiving different therapy (streptokinase alone or in combination with metoprolol or with carvedilol) for up to 168 hr after starting treatment for acute myocardial infarction. We observed increased CuZnSOD activity in erythrocytes isolated from patients treated with streptokinase‐carvedilol (after 6, 24 and 168 hr) and in erythrocytes isolated from patients treated with streptokinase‐metoprolol (after 24 hr). In addition, positive correlation between CuZnSOD and catalase activities was found in erythrocytes isolated from patients that received streptokinase‐carvedilol after 168 hr. As metoprolol does not react directly with hydrogen peroxide, it would appear that combined streptokinase‐metoprolol therapy exerted its effects primarily via by β‐blockade whereas combined streptokinase‐carvedilol therapy appeared to function via both β‐blockade and direct antioxidant mechanisms.</description><subject>Adrenergic Antagonists - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carbazoles - therapeutic use</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Drug Therapy, Combination</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metoprolol - therapeutic use</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - enzymology</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Pharmacology. 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Vascular system</topic><topic>Coronary heart disease</topic><topic>Drug Therapy, Combination</topic><topic>Erythrocytes - enzymology</topic><topic>Female</topic><topic>Free Radical Scavengers - metabolism</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metoprolol - therapeutic use</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - enzymology</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Pharmacology. 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We determined the activities of copper‐zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and glutathione reductase in erythrocytes isolated from patients receiving different therapy (streptokinase alone or in combination with metoprolol or with carvedilol) for up to 168 hr after starting treatment for acute myocardial infarction. We observed increased CuZnSOD activity in erythrocytes isolated from patients treated with streptokinase‐carvedilol (after 6, 24 and 168 hr) and in erythrocytes isolated from patients treated with streptokinase‐metoprolol (after 24 hr). In addition, positive correlation between CuZnSOD and catalase activities was found in erythrocytes isolated from patients that received streptokinase‐carvedilol after 168 hr. As metoprolol does not react directly with hydrogen peroxide, it would appear that combined streptokinase‐metoprolol therapy exerted its effects primarily via by β‐blockade whereas combined streptokinase‐carvedilol therapy appeared to function via both β‐blockade and direct antioxidant mechanisms.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17651317</pmid><doi>10.1111/j.1742-7843.2007.00094.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic Antagonists - therapeutic use Biological and medical sciences Carbazoles - therapeutic use Cardiology. Vascular system Coronary heart disease Drug Therapy, Combination Erythrocytes - enzymology Female Free Radical Scavengers - metabolism Heart Humans Male Medical sciences Metoprolol - therapeutic use Middle Aged Myocardial Infarction - drug therapy Myocardial Infarction - enzymology Myocarditis. Cardiomyopathies Pharmacology. Drug treatments Propanolamines - therapeutic use Streptokinase - therapeutic use Superoxide Dismutase - metabolism |
| title | Carvedilol Increases Copper‐Zinc Superoxide Dismutase Activity in Patients with Acute Myocardial Infarction |
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