Endothelial effects of 3-hydroxyglutaric acid : Implications for glutaric aciduria type I

Infants with glutaric aciduria type 1 (GA1) are subject to intracranial vascular dysfunction. Here, we demonstrate that the disease-specific metabolite 3-hydroxyglutaric acid (3-OH-GA) inhibits basal and vascular endothelial growth factor (VEGF)-induced endothelial cell migration. 3-OH-GA affects th...

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Veröffentlicht in:	Pediatric research 2006-02, Vol.59 (2), p.196-202
Hauptverfasser:	MÜHLHAUSEN, Chris, OTT, Nicola, CHALAJOUR, Fariba, TILKI, Derya, FREUDENBERG, Folke, SHAHHOSSINI, Mona, THIEM, Joachim, ULLRICH, Kurt, BRAULKE, Thomas, ERGÜN, Süleyman
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Antigens, CD Biological and medical sciences Cadherins - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism General aspects Glutarates - metabolism Glutarates - pharmacology Humans Medical sciences Metabolism, Inborn Errors - pathology Vascular Endothelial Growth Factor A - physiology
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