Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis

Summary Activation of intracellular mitogenic signal transduction pathways driven by the ErbB family of receptor tyrosine kinases has been implicated in the development and/or progression of a variety of cancers. Studies on ErbB receptors in osteosarcoma have focused on HER-2 and have produced confl...

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Veröffentlicht in:	Human pathology 2007-08, Vol.38 (8), p.1184-1191
Hauptverfasser:	Wen, Yong Hannah, MD, PhD, Koeppen, Hartmut, MD, PhD, Garcia, Roberto, MD, Chiriboga, Luis, PhD, Tarlow, Branden D., BS, Peters, Brock A., PhD, Eigenbrot, Charles, PhD, Yee, Herman, MD, PhD, Steiner, German, MD, Greco, M. Alba, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Blotting, Western Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Line, Tumor Child Diseases of the osteoarticular system DNA Mutational Analysis DNA, Neoplasm - analysis EGFR Female Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Kinases Male Medical sciences Mutation Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - secondary Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction Protein Structure, Tertiary Proteins Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Tumors Tumors of striated muscle and skeleton
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