The Association Between Metabolic Syndrome and Restrictive Ventilatory Dysfunction in Older Persons
Background. The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of m...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2007-07, Vol.62 (7), p.760-765 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Fimognari, Filippo Luca Pasqualetti, Patrizio Moro, Leo Franco, Alessandro Piccirillo, Gianfranco Pastorelli, Ruggero Rossini, Paolo Maria Incalzi, Raffaele Antonelli |
| description | Background. The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of metabolic syndrome and increased insulin resistance than were obstructive and normal respiratory patterns. Methods. We performed a cross-sectional study of 159 consecutive nondiabetic elderly persons attending two social centers. According to their spirometric pattern, volunteers were classified into the following categories: normal spirometry, obstructive (forced expiratory volume in 1 second/forced vital capacity < 0.70), and restrictive pattern (forced vital capacity < 80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70). Independent correlates of the metabolic syndrome were identified. Results. The prevalence of metabolic syndrome was higher in restrictive (56%) than in both normal (21.4%, p =.001) and obstructive volunteers (12.9%, p =.001). Insulin resistance, as assessed by the log transformation of the HOmeostasis Model Assessment (HOMA), was higher in restrictive than in obstructive and normal volunteers (1 ± 0.6 vs 0.3 ± 0.6 and 0.5 ± 0.5, p |
| doi_str_mv | 10.1093/gerona/62.7.760 |
| format | Article |
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The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of metabolic syndrome and increased insulin resistance than were obstructive and normal respiratory patterns. Methods. We performed a cross-sectional study of 159 consecutive nondiabetic elderly persons attending two social centers. According to their spirometric pattern, volunteers were classified into the following categories: normal spirometry, obstructive (forced expiratory volume in 1 second/forced vital capacity < 0.70), and restrictive pattern (forced vital capacity < 80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70). Independent correlates of the metabolic syndrome were identified. Results. The prevalence of metabolic syndrome was higher in restrictive (56%) than in both normal (21.4%, p =.001) and obstructive volunteers (12.9%, p =.001). Insulin resistance, as assessed by the log transformation of the HOmeostasis Model Assessment (HOMA), was higher in restrictive than in obstructive and normal volunteers (1 ± 0.6 vs 0.3 ± 0.6 and 0.5 ± 0.5, p <.001). Restriction was an independent correlate of metabolic syndrome, also after adjustment for waist circumference and body mass index (odds ratio = 3.23, 95% confidence interval, 1.23–8.48; p =.01). Conclusion. Restrictive, but not obstructive respiratory pattern, is associated with metabolic syndrome and insulin resistance, and does not only reflect a limitation of ventilation due to visceral obesity. Metabolic abnormalities likely mediate cardiovascular risk in patients with restrictive respiratory impairment.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/62.7.760</identifier><identifier>PMID: 17634324</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Correlation analysis ; Cross-Sectional Studies ; Diabetes ; Female ; Gerontology ; Humans ; Insulin Resistance - physiology ; Male ; Metabolic syndrome ; Metabolic Syndrome - etiology ; Older people ; Regression analysis ; Respiration Disorders - complications ; Respiratory diseases ; Respiratory Function Tests ; Risk factors</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-07, Vol.62 (7), p.760-765</ispartof><rights>Copyright Gerontological Society of America, Incorporated Jul 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-b1528dd569560c5305d4dc43844e56e09f382654602b8bb098e9d3e95dea20e93</citedby><cites>FETCH-LOGICAL-c426t-b1528dd569560c5305d4dc43844e56e09f382654602b8bb098e9d3e95dea20e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17634324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fimognari, Filippo Luca</creatorcontrib><creatorcontrib>Pasqualetti, Patrizio</creatorcontrib><creatorcontrib>Moro, Leo</creatorcontrib><creatorcontrib>Franco, Alessandro</creatorcontrib><creatorcontrib>Piccirillo, Gianfranco</creatorcontrib><creatorcontrib>Pastorelli, Ruggero</creatorcontrib><creatorcontrib>Rossini, Paolo Maria</creatorcontrib><creatorcontrib>Incalzi, Raffaele Antonelli</creatorcontrib><title>The Association Between Metabolic Syndrome and Restrictive Ventilatory Dysfunction in Older Persons</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background. The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of metabolic syndrome and increased insulin resistance than were obstructive and normal respiratory patterns. Methods. We performed a cross-sectional study of 159 consecutive nondiabetic elderly persons attending two social centers. According to their spirometric pattern, volunteers were classified into the following categories: normal spirometry, obstructive (forced expiratory volume in 1 second/forced vital capacity < 0.70), and restrictive pattern (forced vital capacity < 80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70). Independent correlates of the metabolic syndrome were identified. Results. The prevalence of metabolic syndrome was higher in restrictive (56%) than in both normal (21.4%, p =.001) and obstructive volunteers (12.9%, p =.001). Insulin resistance, as assessed by the log transformation of the HOmeostasis Model Assessment (HOMA), was higher in restrictive than in obstructive and normal volunteers (1 ± 0.6 vs 0.3 ± 0.6 and 0.5 ± 0.5, p <.001). Restriction was an independent correlate of metabolic syndrome, also after adjustment for waist circumference and body mass index (odds ratio = 3.23, 95% confidence interval, 1.23–8.48; p =.01). Conclusion. Restrictive, but not obstructive respiratory pattern, is associated with metabolic syndrome and insulin resistance, and does not only reflect a limitation of ventilation due to visceral obesity. Metabolic abnormalities likely mediate cardiovascular risk in patients with restrictive respiratory impairment.</description><subject>Aged</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Female</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - etiology</subject><subject>Older people</subject><subject>Regression analysis</subject><subject>Respiration Disorders - complications</subject><subject>Respiratory diseases</subject><subject>Respiratory Function Tests</subject><subject>Risk factors</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1vEzEQhi0Eoh9w5oYsDtw28fpzfSwtpUhBRVBQlYvltSfgsrFb21uaf98tiVqJucxI88yr0YPQm5bMWqLZ_BfkFO1c0pmaKUmeof1Wia4RTFw-n2aidCMIkXvooJQr8lCCvkR7rZKMM8r3kbv4DfiolOSCrSFF_AHqX4CIv0C1fRqCw9830ee0Bmyjx9-g1BxcDbeAf0KsYbA15Q0-2ZTVGN2_iBDx-eAh46-QS4rlFXqxskOB17t-iH6cfrw4PmsW558-Hx8tGseprE3fCtp5L6QWkjjBiPDcO846zkFIIHrFOioFl4T2Xd8T3YH2DLTwYCkBzQ7R-23udU434_SoWYfiYBhshDQWo4hiUkg2ge_-A6_SmOP0m6Gkk0TrTk3QfAu5nErJsDLXOaxt3piWmAf5ZivfSGqUmeRPF293sWO_Bv_E72xPQLMFQqlw97i3-Y-Riilhzi6X5mR5KvmCLk3L7gFTZJCT</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Fimognari, Filippo Luca</creator><creator>Pasqualetti, Patrizio</creator><creator>Moro, Leo</creator><creator>Franco, Alessandro</creator><creator>Piccirillo, Gianfranco</creator><creator>Pastorelli, Ruggero</creator><creator>Rossini, Paolo Maria</creator><creator>Incalzi, Raffaele Antonelli</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>The Association Between Metabolic Syndrome and Restrictive Ventilatory Dysfunction in Older Persons</title><author>Fimognari, Filippo Luca ; Pasqualetti, Patrizio ; Moro, Leo ; Franco, Alessandro ; Piccirillo, Gianfranco ; Pastorelli, Ruggero ; Rossini, Paolo Maria ; Incalzi, Raffaele Antonelli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-b1528dd569560c5305d4dc43844e56e09f382654602b8bb098e9d3e95dea20e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Female</topic><topic>Gerontology</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - etiology</topic><topic>Older people</topic><topic>Regression analysis</topic><topic>Respiration Disorders - complications</topic><topic>Respiratory diseases</topic><topic>Respiratory Function Tests</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fimognari, Filippo Luca</creatorcontrib><creatorcontrib>Pasqualetti, Patrizio</creatorcontrib><creatorcontrib>Moro, Leo</creatorcontrib><creatorcontrib>Franco, Alessandro</creatorcontrib><creatorcontrib>Piccirillo, Gianfranco</creatorcontrib><creatorcontrib>Pastorelli, Ruggero</creatorcontrib><creatorcontrib>Rossini, Paolo Maria</creatorcontrib><creatorcontrib>Incalzi, Raffaele Antonelli</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fimognari, Filippo Luca</au><au>Pasqualetti, Patrizio</au><au>Moro, Leo</au><au>Franco, Alessandro</au><au>Piccirillo, Gianfranco</au><au>Pastorelli, Ruggero</au><au>Rossini, Paolo Maria</au><au>Incalzi, Raffaele Antonelli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association Between Metabolic Syndrome and Restrictive Ventilatory Dysfunction in Older Persons</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>62</volume><issue>7</issue><spage>760</spage><epage>765</epage><pages>760-765</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background. The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of metabolic syndrome and increased insulin resistance than were obstructive and normal respiratory patterns. Methods. We performed a cross-sectional study of 159 consecutive nondiabetic elderly persons attending two social centers. According to their spirometric pattern, volunteers were classified into the following categories: normal spirometry, obstructive (forced expiratory volume in 1 second/forced vital capacity < 0.70), and restrictive pattern (forced vital capacity < 80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70). Independent correlates of the metabolic syndrome were identified. Results. The prevalence of metabolic syndrome was higher in restrictive (56%) than in both normal (21.4%, p =.001) and obstructive volunteers (12.9%, p =.001). Insulin resistance, as assessed by the log transformation of the HOmeostasis Model Assessment (HOMA), was higher in restrictive than in obstructive and normal volunteers (1 ± 0.6 vs 0.3 ± 0.6 and 0.5 ± 0.5, p <.001). Restriction was an independent correlate of metabolic syndrome, also after adjustment for waist circumference and body mass index (odds ratio = 3.23, 95% confidence interval, 1.23–8.48; p =.01). Conclusion. Restrictive, but not obstructive respiratory pattern, is associated with metabolic syndrome and insulin resistance, and does not only reflect a limitation of ventilation due to visceral obesity. Metabolic abnormalities likely mediate cardiovascular risk in patients with restrictive respiratory impairment.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>17634324</pmid><doi>10.1093/gerona/62.7.760</doi><tpages>6</tpages></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-07, Vol.62 (7), p.760-765 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Correlation analysis Cross-Sectional Studies Diabetes Female Gerontology Humans Insulin Resistance - physiology Male Metabolic syndrome Metabolic Syndrome - etiology Older people Regression analysis Respiration Disorders - complications Respiratory diseases Respiratory Function Tests Risk factors |
| title | The Association Between Metabolic Syndrome and Restrictive Ventilatory Dysfunction in Older Persons |
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