Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function

In the present study, we have analysed the effects of transforming growth factor-beta (TGF- β ) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in vivo . Ectopic expression of dominant-negative mutants of the TGF- β type II receptor or type I recep...

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Veröffentlicht in:	Oncogene 2007-07, Vol.26 (33), p.4850-4862
Hauptverfasser:	Schniewind, B, Groth, S, Sebens Müerköster, S, Sipos, B, Schäfer, H, Kalthoff, H, Fändrich, F, Ungefroren, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Activin Receptors, Type I - genetics Activin Receptors, Type I - metabolism Activin Receptors, Type I - physiology Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Apoptosis Biological and medical sciences Cancer Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell activation Cell Biology Cell Line Cell Line, Tumor Cell physiology Cell Proliferation - drug effects Cell receptors Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Cytokines Drug therapy Ectopic expression Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression - drug effects Genetic aspects Growth factors Health aspects Human Genetics Humans Immunoblotting Immunodeficiency Internal Medicine Kinases Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Medicine Medicine & Public Health Mesenchyme Metastases Mice Mice, SCID Miscellaneous Molecular and cellular biology Molecular biology Mutants Mutation Neoplasm Metastasis Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oncology original-article Pancreatic cancer Pancreatic carcinoma Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphorylation - drug effects Protein Binding - drug effects Protein-Serine-Threonine Kinases Rats Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Receptors, Transforming Growth Factor beta - physiology Reverse Transcriptase Polymerase Chain Reaction Signal transduction Smad protein Smad Proteins - metabolism Smad2 protein Thrombospondin Transfection Transforming Growth Factor beta - pharmacology Transforming growth factor-b Transforming growth factors Transplantation Tumor Burden Tumor cells Tumor suppressor genes Tumorigenicity Tumors Vascular endothelial growth factor
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