Amphetamine-induced 50 kHz calls from rat nucleus accumbens: A quantitative mapping study and acoustic analysis
Emission of 50 kHz ultrasonic calls in rats is known to be associated with appetitive behavioural situations and positive social interactions. The purpose of the study was to pharmacologically characterize amphetamine-induced 50 kHz calls and to perform quantitative mapping of this response in the n...
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description | Emission of 50
kHz ultrasonic calls in rats is known to be associated with appetitive behavioural situations and positive social interactions. The purpose of the study was to pharmacologically characterize amphetamine-induced 50
kHz calls and to perform quantitative mapping of this response in the nucleus accumbens. Injections of amphetamine into the nucleus accumbens induced species-typical 50
kHz calls in adult rats. The acoustic parameters of the calls were not affected by different amphetamine doses or combination of agents. The increase in the number of calls occurred predominantly from the accumbens shell and to a lesser degree from the core region. This effect was dose-dependent within the range of 1–20
μg of amphetamine and was reversed by pretreatment with D
1 or D
2 dopamine antagonists (SKF-83566 or raclopride) administered to the same brain site. However, another D
2 dopamine receptor antagonist, haloperidol, which is known to increase the accumbens dopamine level, was ineffective in reversing the increase in call number at the dose studied. On the contrary, intraacumbens haloperidol, when injected alone, caused an increase in 50
kHz calls. It is concluded that the release of dopamine, predominantly in the accumbens shell region, is responsible for production of 50
kHz calls and the calls may indicate an appetitive state compatible with anticipation of reward and positive affect. Both D
1 and D
2 subtypes of dopamine receptors may be necessary to induce 50
kHz calls and signal the appetitive state. |
doi_str_mv | 10.1016/j.bbr.2005.10.012 |
format | Article |
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kHz ultrasonic calls in rats is known to be associated with appetitive behavioural situations and positive social interactions. The purpose of the study was to pharmacologically characterize amphetamine-induced 50
kHz calls and to perform quantitative mapping of this response in the nucleus accumbens. Injections of amphetamine into the nucleus accumbens induced species-typical 50
kHz calls in adult rats. The acoustic parameters of the calls were not affected by different amphetamine doses or combination of agents. The increase in the number of calls occurred predominantly from the accumbens shell and to a lesser degree from the core region. This effect was dose-dependent within the range of 1–20
μg of amphetamine and was reversed by pretreatment with D
1 or D
2 dopamine antagonists (SKF-83566 or raclopride) administered to the same brain site. However, another D
2 dopamine receptor antagonist, haloperidol, which is known to increase the accumbens dopamine level, was ineffective in reversing the increase in call number at the dose studied. On the contrary, intraacumbens haloperidol, when injected alone, caused an increase in 50
kHz calls. It is concluded that the release of dopamine, predominantly in the accumbens shell region, is responsible for production of 50
kHz calls and the calls may indicate an appetitive state compatible with anticipation of reward and positive affect. Both D
1 and D
2 subtypes of dopamine receptors may be necessary to induce 50
kHz calls and signal the appetitive state.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2005.10.012</identifier><identifier>PMID: 16343652</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>50 kHz calls ; Amphetamine ; Amphetamine - administration & dosage ; Amphetamine - pharmacology ; Animals ; Appetitive Behavior - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Brain Mapping - methods ; Caudate Nucleus - drug effects ; Caudate Nucleus - physiology ; Central Nervous System Stimulants - administration & dosage ; Central Nervous System Stimulants - pharmacology ; Dopamine ; Dopamine Antagonists - pharmacology ; Dopamine D2 Receptor Antagonists ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Haloperidol ; Haloperidol - pharmacology ; Interpersonal Relations ; Male ; Mapping study ; Medical sciences ; Microinjections ; Neuropharmacology ; Neurotransmission and behavior ; Nucleus accumbens ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopharmacology ; Putamen - drug effects ; Putamen - physiology ; Rat ; Rats ; Rats, Wistar ; Receptors, Dopamine D1 - antagonists & inhibitors ; Stereotaxic Techniques ; Ultrasonic vocalization ; Vocalization, Animal - drug effects</subject><ispartof>Behavioural brain research, 2006-03, Vol.168 (1), p.64-73</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-fedc621c2eb487133e6877476ab22df0e2bfab8d695cdd628e387fa4deedd2c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2005.10.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17500249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16343652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, Briar</creatorcontrib><creatorcontrib>Leonard, Kevin C.</creatorcontrib><creatorcontrib>Brudzynski, Stefan M.</creatorcontrib><title>Amphetamine-induced 50 kHz calls from rat nucleus accumbens: A quantitative mapping study and acoustic analysis</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Emission of 50
kHz ultrasonic calls in rats is known to be associated with appetitive behavioural situations and positive social interactions. The purpose of the study was to pharmacologically characterize amphetamine-induced 50
kHz calls and to perform quantitative mapping of this response in the nucleus accumbens. Injections of amphetamine into the nucleus accumbens induced species-typical 50
kHz calls in adult rats. The acoustic parameters of the calls were not affected by different amphetamine doses or combination of agents. The increase in the number of calls occurred predominantly from the accumbens shell and to a lesser degree from the core region. This effect was dose-dependent within the range of 1–20
μg of amphetamine and was reversed by pretreatment with D
1 or D
2 dopamine antagonists (SKF-83566 or raclopride) administered to the same brain site. However, another D
2 dopamine receptor antagonist, haloperidol, which is known to increase the accumbens dopamine level, was ineffective in reversing the increase in call number at the dose studied. On the contrary, intraacumbens haloperidol, when injected alone, caused an increase in 50
kHz calls. It is concluded that the release of dopamine, predominantly in the accumbens shell region, is responsible for production of 50
kHz calls and the calls may indicate an appetitive state compatible with anticipation of reward and positive affect. Both D
1 and D
2 subtypes of dopamine receptors may be necessary to induce 50
kHz calls and signal the appetitive state.</description><subject>50 kHz calls</subject><subject>Amphetamine</subject><subject>Amphetamine - administration & dosage</subject><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Appetitive Behavior - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping - methods</subject><subject>Caudate Nucleus - drug effects</subject><subject>Caudate Nucleus - physiology</subject><subject>Central Nervous System Stimulants - administration & dosage</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Dopamine</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Haloperidol</subject><subject>Haloperidol - pharmacology</subject><subject>Interpersonal Relations</subject><subject>Male</subject><subject>Mapping study</subject><subject>Medical sciences</subject><subject>Microinjections</subject><subject>Neuropharmacology</subject><subject>Neurotransmission and behavior</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopharmacology</subject><subject>Putamen - drug effects</subject><subject>Putamen - physiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Dopamine D1 - antagonists & inhibitors</subject><subject>Stereotaxic Techniques</subject><subject>Ultrasonic vocalization</subject><subject>Vocalization, Animal - drug effects</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAUha0K1A6FH8AGeQO7DH4kdgZWo6qlSJXYwNq6sW_AQ-KkflQafj0edRCrq3P16T7OIeQtZ1vOuPp42A5D3ArGuqq3jIsLsuG9Fo3u2t0LsqmMalop-ivyKqUDY6xlHb8kV1zJVqpObMiyn9dfmGH2ARsfXLHoaMfo7_s_1MI0JTrGZaYRMg3FTlgSBWvLPGBIn-iePhYI2WfI_gnpDOvqw0-acnFHCsFVdikpe1sFTMfk02vycoQp4ZtzvSY_7m6_39w3D9--fL3ZPzRWyl1uRnRWCW4FDm2vuZSoeq1brWAQwo0MxTDC0Du166xzSvQoez1C6xCdE3Ynr8mH57lrXB4LpmxmnyxOEwSsJxnNtOzq3Aq-O4NlmNGZNfoZ4tH8s6gC788ApOrIGCFYn_5zumNMtKeNn585rG89eYwmWY-h-ukj2mzc4g1n5hScOZganDkFd2rV4ORf2WuMDQ</recordid><startdate>20060315</startdate><enddate>20060315</enddate><creator>Thompson, Briar</creator><creator>Leonard, Kevin C.</creator><creator>Brudzynski, Stefan M.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060315</creationdate><title>Amphetamine-induced 50 kHz calls from rat nucleus accumbens: A quantitative mapping study and acoustic analysis</title><author>Thompson, Briar ; Leonard, Kevin C. ; Brudzynski, Stefan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-fedc621c2eb487133e6877476ab22df0e2bfab8d695cdd628e387fa4deedd2c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>50 kHz calls</topic><topic>Amphetamine</topic><topic>Amphetamine - administration & dosage</topic><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Appetitive Behavior - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping - methods</topic><topic>Caudate Nucleus - drug effects</topic><topic>Caudate Nucleus - physiology</topic><topic>Central Nervous System Stimulants - administration & dosage</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Dopamine</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haloperidol</topic><topic>Haloperidol - pharmacology</topic><topic>Interpersonal Relations</topic><topic>Male</topic><topic>Mapping study</topic><topic>Medical sciences</topic><topic>Microinjections</topic><topic>Neuropharmacology</topic><topic>Neurotransmission and behavior</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopharmacology</topic><topic>Putamen - drug effects</topic><topic>Putamen - physiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Dopamine D1 - antagonists & inhibitors</topic><topic>Stereotaxic Techniques</topic><topic>Ultrasonic vocalization</topic><topic>Vocalization, Animal - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Briar</creatorcontrib><creatorcontrib>Leonard, Kevin C.</creatorcontrib><creatorcontrib>Brudzynski, Stefan M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Briar</au><au>Leonard, Kevin C.</au><au>Brudzynski, Stefan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amphetamine-induced 50 kHz calls from rat nucleus accumbens: A quantitative mapping study and acoustic analysis</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2006-03-15</date><risdate>2006</risdate><volume>168</volume><issue>1</issue><spage>64</spage><epage>73</epage><pages>64-73</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Emission of 50
kHz ultrasonic calls in rats is known to be associated with appetitive behavioural situations and positive social interactions. The purpose of the study was to pharmacologically characterize amphetamine-induced 50
kHz calls and to perform quantitative mapping of this response in the nucleus accumbens. Injections of amphetamine into the nucleus accumbens induced species-typical 50
kHz calls in adult rats. The acoustic parameters of the calls were not affected by different amphetamine doses or combination of agents. The increase in the number of calls occurred predominantly from the accumbens shell and to a lesser degree from the core region. This effect was dose-dependent within the range of 1–20
μg of amphetamine and was reversed by pretreatment with D
1 or D
2 dopamine antagonists (SKF-83566 or raclopride) administered to the same brain site. However, another D
2 dopamine receptor antagonist, haloperidol, which is known to increase the accumbens dopamine level, was ineffective in reversing the increase in call number at the dose studied. On the contrary, intraacumbens haloperidol, when injected alone, caused an increase in 50
kHz calls. It is concluded that the release of dopamine, predominantly in the accumbens shell region, is responsible for production of 50
kHz calls and the calls may indicate an appetitive state compatible with anticipation of reward and positive affect. Both D
1 and D
2 subtypes of dopamine receptors may be necessary to induce 50
kHz calls and signal the appetitive state.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>16343652</pmid><doi>10.1016/j.bbr.2005.10.012</doi><tpages>10</tpages></addata></record> |
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subjects | 50 kHz calls Amphetamine Amphetamine - administration & dosage Amphetamine - pharmacology Animals Appetitive Behavior - drug effects Behavioral psychophysiology Biological and medical sciences Brain Mapping - methods Caudate Nucleus - drug effects Caudate Nucleus - physiology Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Dopamine Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Haloperidol Haloperidol - pharmacology Interpersonal Relations Male Mapping study Medical sciences Microinjections Neuropharmacology Neurotransmission and behavior Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopharmacology Putamen - drug effects Putamen - physiology Rat Rats Rats, Wistar Receptors, Dopamine D1 - antagonists & inhibitors Stereotaxic Techniques Ultrasonic vocalization Vocalization, Animal - drug effects |
title | Amphetamine-induced 50 kHz calls from rat nucleus accumbens: A quantitative mapping study and acoustic analysis |
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