Evidence that chronic hypoxia causes reversible impairment on male fertility
Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Ex...
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| Veröffentlicht in: | Asian journal of andrology 2008-07, Vol.10 (4), p.602-606 |
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| creator | Verratti, Vittore Berardinelli, Francesco Di Giulio, Camillo Bosco, Gerardo Cacchio, Marisa Pellicciotta, Mario Nicolai, Michele Martinotti, Stefano Tenaglia, Raffaele |
| description | Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Expedition） the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months. Results： Sperm count was found to be lower immediately after returning to sea level （P = 0.0004） and again after a month （P = 0.0008）. Normal levels were reached after 6 months. Spermatic motility （%） shows no reduction immediately after returning to sea level （P = 0.0583）, whereas after 1 month this reduction was significant （P = 0.0066）. After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa （%） increased immediately after returning to sea level （P = 0.0067） and then again after 1 month （P = 0.0004）. After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level （P = 0.0024） and then again after 1 month （P = 0.0021）. After 6 months there was a recovery to pre-hypoxic exposure values. Conclusion： Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility. |
| doi_str_mv | 10.1111/j.1745-7262.2008.00346.x |
| format | Article |
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Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Expedition） the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months. Results： Sperm count was found to be lower immediately after returning to sea level （P = 0.0004） and again after a month （P = 0.0008）. Normal levels were reached after 6 months. Spermatic motility （%） shows no reduction immediately after returning to sea level （P = 0.0583）, whereas after 1 month this reduction was significant （P = 0.0066）. After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa （%） increased immediately after returning to sea level （P = 0.0067） and then again after 1 month （P = 0.0004）. After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level （P = 0.0024） and then again after 1 month （P = 0.0021）. After 6 months there was a recovery to pre-hypoxic exposure values. Conclusion： Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility.</description><identifier>ISSN: 1008-682X</identifier><identifier>EISSN: 1745-7262</identifier><identifier>DOI: 10.1111/j.1745-7262.2008.00346.x</identifier><identifier>PMID: 18097511</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adaptation, Physiological - physiology ; Adult ; Aged ; Altitude ; high altitude ; Humans ; hypoxia ; Hypoxia - complications ; Infertility, Male - etiology ; Infertility, Male - pathology ; Infertility, Male - physiopathology ; Male ; male fertility ; Middle Aged ; Mountaineering ; Oligospermia - etiology ; Oligospermia - pathology ; Oligospermia - physiopathology ; seminological parameters ; Sperm Count ; Sperm Motility - physiology ; Spermatogenesis - physiology ; 可逆损伤 ; 生殖力</subject><ispartof>Asian journal of andrology, 2008-07, Vol.10 (4), p.602-606</ispartof><rights>2008, Asian Journal of Andrology, SIMM and SJTU. All rights reserved.</rights><rights>Copyright Nature Publishing Group Jul 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4716-1eb1b6c8bf45ef9582e8f95cfec23bd2583f81cd1754bbc81f16b8b61790a91f3</citedby><cites>FETCH-LOGICAL-c4716-1eb1b6c8bf45ef9582e8f95cfec23bd2583f81cd1754bbc81f16b8b61790a91f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84127X/84127X.jpg</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18097511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verratti, Vittore</creatorcontrib><creatorcontrib>Berardinelli, Francesco</creatorcontrib><creatorcontrib>Di Giulio, Camillo</creatorcontrib><creatorcontrib>Bosco, Gerardo</creatorcontrib><creatorcontrib>Cacchio, Marisa</creatorcontrib><creatorcontrib>Pellicciotta, Mario</creatorcontrib><creatorcontrib>Nicolai, Michele</creatorcontrib><creatorcontrib>Martinotti, Stefano</creatorcontrib><creatorcontrib>Tenaglia, Raffaele</creatorcontrib><title>Evidence that chronic hypoxia causes reversible impairment on male fertility</title><title>Asian journal of andrology</title><addtitle>Asian Journal of Andrology</addtitle><description>Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Expedition） the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months. Results： Sperm count was found to be lower immediately after returning to sea level （P = 0.0004） and again after a month （P = 0.0008）. Normal levels were reached after 6 months. Spermatic motility （%） shows no reduction immediately after returning to sea level （P = 0.0583）, whereas after 1 month this reduction was significant （P = 0.0066）. After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa （%） increased immediately after returning to sea level （P = 0.0067） and then again after 1 month （P = 0.0004）. After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level （P = 0.0024） and then again after 1 month （P = 0.0021）. After 6 months there was a recovery to pre-hypoxic exposure values. Conclusion： Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility.</description><subject>Adaptation, Physiological - physiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Altitude</subject><subject>high altitude</subject><subject>Humans</subject><subject>hypoxia</subject><subject>Hypoxia - complications</subject><subject>Infertility, Male - etiology</subject><subject>Infertility, Male - pathology</subject><subject>Infertility, Male - physiopathology</subject><subject>Male</subject><subject>male fertility</subject><subject>Middle Aged</subject><subject>Mountaineering</subject><subject>Oligospermia - etiology</subject><subject>Oligospermia - pathology</subject><subject>Oligospermia - physiopathology</subject><subject>seminological parameters</subject><subject>Sperm Count</subject><subject>Sperm Motility - physiology</subject><subject>Spermatogenesis - physiology</subject><subject>可逆损伤</subject><subject>生殖力</subject><issn>1008-682X</issn><issn>1745-7262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkE1vGyEQhlHVqknT_oUK9dDbbhl2WdhDD1aUfslKL6nUGwI8xLj74cBuYv_74thqpJ7CZUbMM6_gIYQCKyGfT5sSZC0KyRtecsZUyVhVN-XuBTn_N3iZ-zwqGsV_n5E3KW0Y4xW07WtyBoq1UgCck-XVfVjh4JBOazNRt47jEBxd77fjLhjqzJww0Yj3GFOwHdLQb02IPQ4THQfam3zlMU6hC9P-LXnlTZfw3alekF9frm4uvxXLn1-_Xy6WhaslNAWgBds4ZX0t0LdCcVS5OI-OV3bFhaq8ArcCKWprnQIPjVW2Adky04KvLsjHY-42jnczpkn3ITnsOjPgOCctmawEEyKDH_4DN-Mch_w2zSEjkos6Q-oIuTimFNHrbQy9iXsNTB90640-WNUHq_qgWz_q1ru8-v6UP9seV0-LJ78Z-HwEHkKH-2cH68WPxXXunj7g1uNwexeGW22N--NzmuaybYSCuvoLU5OZ6g</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Verratti, Vittore</creator><creator>Berardinelli, Francesco</creator><creator>Di Giulio, Camillo</creator><creator>Bosco, Gerardo</creator><creator>Cacchio, Marisa</creator><creator>Pellicciotta, Mario</creator><creator>Nicolai, Michele</creator><creator>Martinotti, Stefano</creator><creator>Tenaglia, Raffaele</creator><general>Blackwell Publishing Ltd</general><general>Medknow Publications & Media Pvt. 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Academic</collection><jtitle>Asian journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verratti, Vittore</au><au>Berardinelli, Francesco</au><au>Di Giulio, Camillo</au><au>Bosco, Gerardo</au><au>Cacchio, Marisa</au><au>Pellicciotta, Mario</au><au>Nicolai, Michele</au><au>Martinotti, Stefano</au><au>Tenaglia, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that chronic hypoxia causes reversible impairment on male fertility</atitle><jtitle>Asian journal of andrology</jtitle><addtitle>Asian Journal of Andrology</addtitle><date>2008-07</date><risdate>2008</risdate><volume>10</volume><issue>4</issue><spage>602</spage><epage>606</epage><pages>602-606</pages><issn>1008-682X</issn><eissn>1745-7262</eissn><abstract>Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Expedition） the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months. Results： Sperm count was found to be lower immediately after returning to sea level （P = 0.0004） and again after a month （P = 0.0008）. Normal levels were reached after 6 months. Spermatic motility （%） shows no reduction immediately after returning to sea level （P = 0.0583）, whereas after 1 month this reduction was significant （P = 0.0066）. After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa （%） increased immediately after returning to sea level （P = 0.0067） and then again after 1 month （P = 0.0004）. After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level （P = 0.0024） and then again after 1 month （P = 0.0021）. After 6 months there was a recovery to pre-hypoxic exposure values. Conclusion： Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18097511</pmid><doi>10.1111/j.1745-7262.2008.00346.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation, Physiological - physiology Adult Aged Altitude high altitude Humans hypoxia Hypoxia - complications Infertility, Male - etiology Infertility, Male - pathology Infertility, Male - physiopathology Male male fertility Middle Aged Mountaineering Oligospermia - etiology Oligospermia - pathology Oligospermia - physiopathology seminological parameters Sperm Count Sperm Motility - physiology Spermatogenesis - physiology 可逆损伤 生殖力 |
| title | Evidence that chronic hypoxia causes reversible impairment on male fertility |
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