Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transge...

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Veröffentlicht in:	Human molecular genetics 2007-08, Vol.16 (15), p.1845-1861
Hauptverfasser:	Kuhn, Alexandre, Goldstein, Darlene R., Hodges, Angela, Strand, Andrew D., Sengstag, Thierry, Kooperberg, Charles, Becanovic, Kristina, Pouladi, Mahmoud A., Sathasivam, Kirupa, Cha, Jang-Ho J., Hannan, Anthony J., Hayden, Michael R., Leavitt, Blair R., Dunnett, Stephen B., Ferrante, Robert J., Albin, Roger, Shelbourne, Peggy, Delorenzi, Mauro, Augood, Sarah J., Faull, Richard L.M., Olson, James M., Bates, Gillian P., Jones, Lesley, Luthi-Carter, Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Brain - pathology Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Fundamental and applied biological sciences. Psychology Gene Dosage Gene Expression Genetics of eukaryotes. Biological and molecular evolution Humans Huntingtin Protein Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Medical sciences Mice Mice, Mutant Strains Molecular and cellular biology Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype RNA, Messenger - metabolism
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