In vitro effects of chorionic gonadotropin hormone on human adipose development
It is well known that pregnancy is associated with fat weight gain. However, the mechanisms whereby fat mass accumulation is controlled during this period are poorly understood. Therefore, we attempted to determine whether human chorionic gonadotropin (HCG), in vitro, influences human adipose tissue...
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| Veröffentlicht in: | Journal of endocrinology 2007-08, Vol.194 (2), p.313-325 |
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| creator | Dos Santos, Esther Dieudonné, Marie-Noëlle Leneveu, Marie-Christine Pecquery, René Serazin, Valérie Giudicelli, Yves |
| description | It is well known that pregnancy is associated with fat weight gain. However, the mechanisms whereby fat mass accumulation is controlled during this period are poorly understood. Therefore, we attempted to determine whether human chorionic gonadotropin (HCG), in vitro, influences human adipose tissue development and/or metabolism. For the first time, HCG/LH receptor was characterized in human adipose cells. We also demonstrated that physiological concentrations of HCG, while unaltering both lipolysis and expression of two markers of lipogenesis (FAS and ADD1) in human mature adipocytes, stimulate human preadipocyte growth via the activation of a protein kinase A-independent mitogen-activated protein kinase/c-fos signaling pathway. HCG also moderately increases the preadipocyte differentiation capacityas reflected by enhanced glycerophosphate dehydrogenase activity and expression of key adipogenic transcriptional factors (C/enhancer-binding protein α and peroxisome proliferator-activated receptor γ 2). Finally, HCG significantly stimulates the secretion of the proadipogenic factor, leptin, from human adipose tissue. Taken altogether, these data suggest that the proadipogenic effect of HCG in human preadipocytes contributes to explain why increased fat storage occurs during the first trimester of pregnancy. |
| doi_str_mv | 10.1677/JOE-06-0101 |
| format | Article |
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However, the mechanisms whereby fat mass accumulation is controlled during this period are poorly understood. Therefore, we attempted to determine whether human chorionic gonadotropin (HCG), in vitro, influences human adipose tissue development and/or metabolism. For the first time, HCG/LH receptor was characterized in human adipose cells. We also demonstrated that physiological concentrations of HCG, while unaltering both lipolysis and expression of two markers of lipogenesis (FAS and ADD1) in human mature adipocytes, stimulate human preadipocyte growth via the activation of a protein kinase A-independent mitogen-activated protein kinase/c-fos signaling pathway. HCG also moderately increases the preadipocyte differentiation capacityas reflected by enhanced glycerophosphate dehydrogenase activity and expression of key adipogenic transcriptional factors (C/enhancer-binding protein α and peroxisome proliferator-activated receptor γ 2). Finally, HCG significantly stimulates the secretion of the proadipogenic factor, leptin, from human adipose tissue. Taken altogether, these data suggest that the proadipogenic effect of HCG in human preadipocytes contributes to explain why increased fat storage occurs during the first trimester of pregnancy.</description><identifier>ISSN: 0022-0795</identifier><identifier>EISSN: 1479-6805</identifier><identifier>DOI: 10.1677/JOE-06-0101</identifier><identifier>PMID: 17641281</identifier><identifier>CODEN: JOENAK</identifier><language>eng</language><publisher>Colchester: BioScientifica</publisher><subject>Adipose Tissue - growth & development ; Adipose Tissue - metabolism ; Biological and medical sciences ; CCAAT-Enhancer-Binding Proteins - genetics ; CCAAT-Enhancer-Binding Proteins - metabolism ; Cell Differentiation - drug effects ; Cell Proliferation - drug effects ; Cells, Cultured ; Chorionic Gonadotropin - pharmacology ; Cyclic AMP - metabolism ; Enzyme Activation ; Female ; Fundamental and applied biological sciences. 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However, the mechanisms whereby fat mass accumulation is controlled during this period are poorly understood. Therefore, we attempted to determine whether human chorionic gonadotropin (HCG), in vitro, influences human adipose tissue development and/or metabolism. For the first time, HCG/LH receptor was characterized in human adipose cells. We also demonstrated that physiological concentrations of HCG, while unaltering both lipolysis and expression of two markers of lipogenesis (FAS and ADD1) in human mature adipocytes, stimulate human preadipocyte growth via the activation of a protein kinase A-independent mitogen-activated protein kinase/c-fos signaling pathway. HCG also moderately increases the preadipocyte differentiation capacityas reflected by enhanced glycerophosphate dehydrogenase activity and expression of key adipogenic transcriptional factors (C/enhancer-binding protein α and peroxisome proliferator-activated receptor γ 2). 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Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Genes, fos</subject><subject>Glycerolphosphate Dehydrogenase - metabolism</subject><subject>Humans</subject><subject>Leptin - genetics</subject><subject>Leptin - metabolism</subject><subject>Leptin - secretion</subject><subject>MAP Kinase Signaling System - drug effects</subject><subject>PPAR gamma - genetics</subject><subject>PPAR gamma - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Receptors, LH - analysis</subject><subject>Receptors, LH - metabolism</subject><subject>Regular papers</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</subject><issn>0022-0795</issn><issn>1479-6805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c9PHCEUB3DS1NR121PvDZf2YkYf7AAzR7OxusZkL3omDD9cmhkYYXaN_72Y3UbjwRMEPu9Bvg-hnwTOCBfi_GZ9WQGvgAD5gmakFm3FG2Bf0QyA0gpEy47RSc7_AAgjYvENHRPBa0IbMkPrVcA7P6WIrXNWTxlHh_UmJh-D1_ghBmViuR59wOV0iMHiWLbbQQWsjB9jttjYne3jONgwfUdHTvXZ_jisc3T_9_JueV3drq9Wy4vbqmPApkrRummYXlCmjFadcobWrgUhOGmdEQ03rlGaMqFbTgkD0XXQic6aVnDNFFnM0Z993zHFx63Nkxx81rbvVbBxm6UAsag5bwo83UOdYs7JOjkmP6j0LAnI1_xkyU8Cl6_5Ff3r0HbbDda82UNgBfw-AJW16l1SQfv85pq2LgNoi6N7t_EPmyefrOx8zNqXiLzzWr1__f_0ShHZF32wn_34BYC3mPs</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Dos Santos, Esther</creator><creator>Dieudonné, Marie-Noëlle</creator><creator>Leneveu, Marie-Christine</creator><creator>Pecquery, René</creator><creator>Serazin, Valérie</creator><creator>Giudicelli, Yves</creator><general>BioScientifica</general><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>In vitro effects of chorionic gonadotropin hormone on human adipose development</title><author>Dos Santos, Esther ; Dieudonné, Marie-Noëlle ; Leneveu, Marie-Christine ; Pecquery, René ; Serazin, Valérie ; Giudicelli, Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b505t-a24885c325adcabafd24f9077619fd786df8ac257c9621507bb0b7bed976c5a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adipose Tissue - growth & development</topic><topic>Adipose Tissue - metabolism</topic><topic>Biological and medical sciences</topic><topic>CCAAT-Enhancer-Binding Proteins - genetics</topic><topic>CCAAT-Enhancer-Binding Proteins - metabolism</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Cyclic AMP - metabolism</topic><topic>Enzyme Activation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Genes, fos</topic><topic>Glycerolphosphate Dehydrogenase - metabolism</topic><topic>Humans</topic><topic>Leptin - genetics</topic><topic>Leptin - metabolism</topic><topic>Leptin - secretion</topic><topic>MAP Kinase Signaling System - drug effects</topic><topic>PPAR gamma - genetics</topic><topic>PPAR gamma - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Receptors, LH - analysis</topic><topic>Receptors, LH - metabolism</topic><topic>Regular papers</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - analysis</topic><topic>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dos Santos, Esther</creatorcontrib><creatorcontrib>Dieudonné, Marie-Noëlle</creatorcontrib><creatorcontrib>Leneveu, Marie-Christine</creatorcontrib><creatorcontrib>Pecquery, René</creatorcontrib><creatorcontrib>Serazin, Valérie</creatorcontrib><creatorcontrib>Giudicelli, Yves</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dos Santos, Esther</au><au>Dieudonné, Marie-Noëlle</au><au>Leneveu, Marie-Christine</au><au>Pecquery, René</au><au>Serazin, Valérie</au><au>Giudicelli, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro effects of chorionic gonadotropin hormone on human adipose development</atitle><jtitle>Journal of endocrinology</jtitle><addtitle>J Endocrinol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>194</volume><issue>2</issue><spage>313</spage><epage>325</epage><pages>313-325</pages><issn>0022-0795</issn><eissn>1479-6805</eissn><coden>JOENAK</coden><abstract>It is well known that pregnancy is associated with fat weight gain. However, the mechanisms whereby fat mass accumulation is controlled during this period are poorly understood. Therefore, we attempted to determine whether human chorionic gonadotropin (HCG), in vitro, influences human adipose tissue development and/or metabolism. For the first time, HCG/LH receptor was characterized in human adipose cells. We also demonstrated that physiological concentrations of HCG, while unaltering both lipolysis and expression of two markers of lipogenesis (FAS and ADD1) in human mature adipocytes, stimulate human preadipocyte growth via the activation of a protein kinase A-independent mitogen-activated protein kinase/c-fos signaling pathway. HCG also moderately increases the preadipocyte differentiation capacityas reflected by enhanced glycerophosphate dehydrogenase activity and expression of key adipogenic transcriptional factors (C/enhancer-binding protein α and peroxisome proliferator-activated receptor γ 2). 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| subjects | Adipose Tissue - growth & development Adipose Tissue - metabolism Biological and medical sciences CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Chorionic Gonadotropin - pharmacology Cyclic AMP - metabolism Enzyme Activation Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, fos Glycerolphosphate Dehydrogenase - metabolism Humans Leptin - genetics Leptin - metabolism Leptin - secretion MAP Kinase Signaling System - drug effects PPAR gamma - genetics PPAR gamma - metabolism Pregnancy Pregnancy Trimester, First Receptors, LH - analysis Receptors, LH - metabolism Regular papers Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue |
| title | In vitro effects of chorionic gonadotropin hormone on human adipose development |
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