Solution structure and dynamics of human metallothionein-3 (MT-3)

Alzheimer’s disease is characterized by progressive loss of neurons accompanied by the formation of intraneural neurofibrillary tangles and extracellular amyloid plaques. Human neuronal growth inhibitory factor, classified as metallothionein-3 (MT-3), was found to be related to the neurotrophic acti...

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Veröffentlicht in:	FEBS letters 2006-02, Vol.580 (3), p.795-800
Hauptverfasser:	Wang, Hui, Zhang, Qi, Cai, Bin, Li, Hongyan, Sze, Kong-Hung, Huang, Zhong-Xian, Wu, Hou-Ming, Sun, Hongzhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid - chemistry Amyloid - metabolism Animals Cell Survival Dendrites - metabolism Dynamics glutathione-S transferase Growth inhibitory factor GST heteronuclear multiple-quantum coherence heteronuclear single-quantum coherence HMQC HSQC Humans Metallothionein-3 metallothioneins Mice MT-3 MTs Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism neurofibrillar tangles NFT NMR NOE NOESY Nuclear Magnetic Resonance, Biomolecular nuclear Overhauser effect nuclear Overhauser enhancement spectroscopy Protein Structure, Secondary Protein Structure, Tertiary RMSD root mean square deviation senile plaques Structure-Activity Relationship Structures TOCSY total correlation spectroscopy Zinc
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