Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid β and impairment of learning and memory

An accumulation of amyloid β peptide (Aβ) due to an imbalance between anabolism and catabolism triggers Alzheimer's disease (AD). Neprilysin is a rate-limiting peptidase, which participates in the catabolism of Aβ in brain. We investigated whether rats continuously infused with thiorphan, a spe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Behavioural brain research 2006-03, Vol.168 (1), p.83-91
Hauptverfasser:	Mouri, Akihiro, Zou, Li-Bo, Iwata, Nobuhisa, Saido, Takaomi C., Wang, Dayong, Wang, Min-Wei, Noda, Yukihiro, Nabeshima, Toshitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Adult and adolescent clinical studies Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid β Animal Animals Biological and medical sciences Brain Chemistry - drug effects Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cognitive dysfunction Cues Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fear - drug effects Fear - psychology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Injections, Intraventricular Learning Learning - drug effects Learning. Memory Male Maze Learning - drug effects Medical sciences Memory - drug effects Memory, Short-Term - drug effects Neprilysin Neprilysin - antagonists & inhibitors Neurology Nicotine - pharmacology Nicotinic Agonists - pharmacology Organic mental disorders. Neuropsychology Protease Inhibitors - administration & dosage Protease Inhibitors - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rat Rats Rats, Wistar Recognition (Psychology) - drug effects Thiorphan Thiorphan - administration & dosage Thiorphan - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!