Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland
Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2008-06, Vol.11 (2), p.173-180 |
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| container_title | Prostate cancer and prostatic diseases |
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| creator | Noel, E E Ragavan, N Walsh, M J James, S Y Matanhelia, S S Nicholson, C M Lu, Y-J Martin, F L |
| description | Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained. |
| doi_str_mv | 10.1038/sj.pcan.4500997 |
| format | Article |
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From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.</description><identifier>ISSN: 1365-7852</identifier><identifier>EISSN: 1476-5608</identifier><identifier>DOI: 10.1038/sj.pcan.4500997</identifier><identifier>PMID: 17646851</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenocarcinoma ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell adhesion ; DNA microarrays ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Genomes ; Humans ; Male ; Methods ; Middle Aged ; Molecular modelling ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Neurogenesis ; Organ Specificity ; original-article ; Physiological aspects ; Prostate ; Prostate - metabolism ; Prostate - pathology ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; RNA, Neoplasm - biosynthesis ; RNA, Neoplasm - genetics ; RNA-directed DNA polymerase ; Signal transduction ; Signal Transduction - genetics ; Transcription, Genetic</subject><ispartof>Prostate cancer and prostatic diseases, 2008-06, Vol.11 (2), p.173-180</ispartof><rights>Springer Nature Limited 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2008</rights><rights>Nature Publishing Group 2008.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-dd47375184f9cfb83a006e460be3a279d8344e93a4414748c4db437af11447233</citedby><cites>FETCH-LOGICAL-c489t-dd47375184f9cfb83a006e460be3a279d8344e93a4414748c4db437af11447233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.pcan.4500997$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.pcan.4500997$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17646851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noel, E E</creatorcontrib><creatorcontrib>Ragavan, N</creatorcontrib><creatorcontrib>Walsh, M J</creatorcontrib><creatorcontrib>James, S Y</creatorcontrib><creatorcontrib>Matanhelia, S S</creatorcontrib><creatorcontrib>Nicholson, C M</creatorcontrib><creatorcontrib>Lu, Y-J</creatorcontrib><creatorcontrib>Martin, F L</creatorcontrib><title>Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland</title><title>Prostate cancer and prostatic diseases</title><addtitle>Prostate Cancer Prostatic Dis</addtitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><description>Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell adhesion</subject><subject>DNA microarrays</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Humans</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Molecular modelling</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neurogenesis</subject><subject>Organ Specificity</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Prostate</subject><subject>Prostate - metabolism</subject><subject>Prostate - pathology</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Neoplasm - biosynthesis</subject><subject>RNA, Neoplasm - genetics</subject><subject>RNA-directed DNA polymerase</subject><subject>Signal transduction</subject><subject>Signal Transduction - genetics</subject><subject>Transcription, Genetic</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kk1v1DAQhiMEoqVw5oYikHrL1o6d2D5W5VOqxAXOljcZb7xK7GA7EvDrmeyutBRR-WBr5pkZz6u3KF5TsqGEyZu038yd8RveEKKUeFJcUi7aqmmJfIpv1jaVkE19UbxIaU-QoYo8Ly6oaHkrG3pZhPfOWojgszNjuQMPJfycI6Tkgi-dL_MA5QzRzQNEJH4HJLowzSZCX-ZwyOdofHJ5rTjkgz2Eh2UyvpxjSNlkKHej8f3L4pk1Y4JXp_uq-P7xw7e7z9X9109f7m7vq45Llau-54KJhkpuVWe3khlCWuAt2QIztVC9ZJyDYoZzXJjLjvdbzoSxlHIuasauiutjXxz_Y4GU9eRSByP-AcKStCCC1aRuEHz3D7gPS_T4N123vGFU4SSk3j5K1YooVkt-brUzI2jnbUBhunWuvqVC1UJKJZHa_IfC08PkOpTPOow_KLj-q2AAM-YhhXFZ9U4PwZsj2KHkKYLVc3STib80JXq1i057vdpFn-yCFW9Oay3bCfozf_IHAuQIJEz5HcTz3o_1_AMsGcnT</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Noel, E E</creator><creator>Ragavan, N</creator><creator>Walsh, M J</creator><creator>James, S Y</creator><creator>Matanhelia, S S</creator><creator>Nicholson, C M</creator><creator>Lu, Y-J</creator><creator>Martin, F L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland</title><author>Noel, E E ; Ragavan, N ; Walsh, M J ; James, S Y ; Matanhelia, S S ; Nicholson, C M ; Lu, Y-J ; Martin, F L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-dd47375184f9cfb83a006e460be3a279d8344e93a4414748c4db437af11447233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - 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Academic</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noel, E E</au><au>Ragavan, N</au><au>Walsh, M J</au><au>James, S Y</au><au>Matanhelia, S S</au><au>Nicholson, C M</au><au>Lu, Y-J</au><au>Martin, F L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>11</volume><issue>2</issue><spage>173</spage><epage>180</epage><pages>173-180</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract>Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17646851</pmid><doi>10.1038/sj.pcan.4500997</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Aged Biomedical and Life Sciences Biomedicine Cancer Research Cell adhesion DNA microarrays Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Genomes Humans Male Methods Middle Aged Molecular modelling Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neurogenesis Organ Specificity original-article Physiological aspects Prostate Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics RNA-directed DNA polymerase Signal transduction Signal Transduction - genetics Transcription, Genetic |
| title | Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland |
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