Linear Relationship of Valproate Serum Concentration to Response and Optimal Serum Levels for Acute Mania

OBJECTIVE: Several studies have shown that achieving adequate serum valproate levels is critical to rapid stabilization of acute mania, but estimates of the target therapeutic level have been imprecise. A post hoc analysis of pooled intent-to-treat data from three randomized, placebo-controlled stud...

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Veröffentlicht in:	The American journal of psychiatry 2006-02, Vol.163 (2), p.272-275
Hauptverfasser:	Allen, Michael H., Hirschfeld, Robert M., Wozniak, Patricia J., Baker, Ph.D., Jeffrey D., Bowden, Charles L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Adult and adolescent clinical studies Analysis of Variance Antimanic Agents - administration & dosage Antimanic Agents - blood Antimanic Agents - therapeutic use Behavioral sciences Biological and medical sciences Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - drug therapy Bipolar Disorder - psychology Clinical trials Dose-Response Relationship, Drug Drug Administration Schedule Drug therapy Female Groups Humans Linear Models Male Mania Manic depression Medical sciences Mood disorders Neuropharmacology Patients Pharmacology. Drug treatments Placebos Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Randomized Controlled Trials as Topic Regression analysis Treatment Outcome Valproic Acid - administration & dosage Valproic Acid - blood Valproic Acid - therapeutic use
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