Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii
ISAba1-like sequences were identified immediately upstream of the blaampC gene in ceftazidime-resistant Acinetobacter baumannii isolates, but were absent in ceftazidime-susceptible A. baumannii isolates. AmpC over-expression resulted from insertion of ISAba1-like sequences upstream of blaampC. ISAba...
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| Veröffentlicht in: | Clinical microbiology and infection 2006-02, Vol.12 (2), p.123-130 |
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| creator | Héritier, C. Poirel, L. Nordmann, P. |
| description | ISAba1-like sequences were identified immediately upstream of the blaampC gene in ceftazidime-resistant Acinetobacter baumannii isolates, but were absent in ceftazidime-susceptible A. baumannii isolates. AmpC over-expression resulted from insertion of ISAba1-like sequences upstream of blaampC. ISAba1 provided strong promoter sequences, and it was demonstrated that the change in the ribosome binding site sequence resulting from insertion of ISAba1 did not influence expression of the blaampC gene. Sequence analysis revealed that AmpC sequences of A. baumannii isolates were almost identical and that ISAba1 elements had a high percentage of identity. |
| doi_str_mv | 10.1111/j.1469-0691.2005.01320.x |
| format | Article |
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AmpC over-expression resulted from insertion of ISAba1-like sequences upstream of blaampC. ISAba1 provided strong promoter sequences, and it was demonstrated that the change in the ribosome binding site sequence resulting from insertion of ISAba1 did not influence expression of the blaampC gene. Sequence analysis revealed that AmpC sequences of A. baumannii isolates were almost identical and that ISAba1 elements had a high percentage of identity.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2005.01320.x</identifier><identifier>PMID: 16441449</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Acinetobacter baumannii ; Acinetobacter baumannii - enzymology ; Acinetobacter baumannii - genetics ; Amino Acid Sequence ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Proteins - biosynthesis ; Bacterial Proteins - genetics ; Base Sequence ; beta-Lactam Resistance - genetics ; beta-Lactamases - genetics ; Biological and medical sciences ; ceftazidime resistance ; cephalosporinase ; Cephalosporinase - biosynthesis ; Cephalosporinase - genetics ; DNA Transposable Elements - genetics ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Gene Expression ; Infectious diseases ; insertion sequence ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Pharmacology. 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AmpC over-expression resulted from insertion of ISAba1-like sequences upstream of blaampC. ISAba1 provided strong promoter sequences, and it was demonstrated that the change in the ribosome binding site sequence resulting from insertion of ISAba1 did not influence expression of the blaampC gene. Sequence analysis revealed that AmpC sequences of A. baumannii isolates were almost identical and that ISAba1 elements had a high percentage of identity.</description><subject>Acinetobacter baumannii</subject><subject>Acinetobacter baumannii - enzymology</subject><subject>Acinetobacter baumannii - genetics</subject><subject>Amino Acid Sequence</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Proteins - biosynthesis</subject><subject>Bacterial Proteins - genetics</subject><subject>Base Sequence</subject><subject>beta-Lactam Resistance - genetics</subject><subject>beta-Lactamases - genetics</subject><subject>Biological and medical sciences</subject><subject>ceftazidime resistance</subject><subject>cephalosporinase</subject><subject>Cephalosporinase - biosynthesis</subject><subject>Cephalosporinase - genetics</subject><subject>DNA Transposable Elements - genetics</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>Gene Expression</subject><subject>Infectious diseases</subject><subject>insertion sequence</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Proteins - biosynthesis</topic><topic>Bacterial Proteins - genetics</topic><topic>Base Sequence</topic><topic>beta-Lactam Resistance - genetics</topic><topic>beta-Lactamases - genetics</topic><topic>Biological and medical sciences</topic><topic>ceftazidime resistance</topic><topic>cephalosporinase</topic><topic>Cephalosporinase - biosynthesis</topic><topic>Cephalosporinase - genetics</topic><topic>DNA Transposable Elements - genetics</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>Gene Expression</topic><topic>Infectious diseases</topic><topic>insertion sequence</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Sequence Data</topic><topic>Pharmacology. Drug treatments</topic><topic>Promoter Regions, Genetic</topic><topic>promoter sequence</topic><topic>Protein Biosynthesis</topic><topic>Recombination, Genetic</topic><topic>Regulatory Sequences, Nucleic Acid - genetics</topic><topic>ribosome binding site</topic><topic>RNA, Messenger - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Héritier, C.</creatorcontrib><creatorcontrib>Poirel, L.</creatorcontrib><creatorcontrib>Nordmann, P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Héritier, C.</au><au>Poirel, L.</au><au>Nordmann, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2006-02</date><risdate>2006</risdate><volume>12</volume><issue>2</issue><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>ISAba1-like sequences were identified immediately upstream of the blaampC gene in ceftazidime-resistant Acinetobacter baumannii isolates, but were absent in ceftazidime-susceptible A. baumannii isolates. AmpC over-expression resulted from insertion of ISAba1-like sequences upstream of blaampC. ISAba1 provided strong promoter sequences, and it was demonstrated that the change in the ribosome binding site sequence resulting from insertion of ISAba1 did not influence expression of the blaampC gene. Sequence analysis revealed that AmpC sequences of A. baumannii isolates were almost identical and that ISAba1 elements had a high percentage of identity.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>16441449</pmid><doi>10.1111/j.1469-0691.2005.01320.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical microbiology and infection, 2006-02, Vol.12 (2), p.123-130 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acinetobacter baumannii Acinetobacter baumannii - enzymology Acinetobacter baumannii - genetics Amino Acid Sequence Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Base Sequence beta-Lactam Resistance - genetics beta-Lactamases - genetics Biological and medical sciences ceftazidime resistance cephalosporinase Cephalosporinase - biosynthesis Cephalosporinase - genetics DNA Transposable Elements - genetics DNA, Bacterial - chemistry DNA, Bacterial - genetics Gene Expression Infectious diseases insertion sequence Medical sciences Microbial Sensitivity Tests Molecular Sequence Data Pharmacology. Drug treatments Promoter Regions, Genetic promoter sequence Protein Biosynthesis Recombination, Genetic Regulatory Sequences, Nucleic Acid - genetics ribosome binding site RNA, Messenger - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid |
| title | Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii |
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