Central tolerance: good but imperfect

T‐cell development is a highly coordinated process that depends on interactions between thymocytes, thymic epithelium, and bone marrow (BM)‐derived dendritic cells (DCs). Before entering the peripheral T‐cell pool, thymocytes are subject to negative selection, a process that eliminates (or deletes)...

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Bibliographische Detailangaben
Veröffentlicht in:	Immunological reviews 2006-02, Vol.209 (1), p.290-296
Hauptverfasser:	Gallegos, Alena M., Bevan, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Autoantigens - immunology Cell Communication Clonal Deletion Dendritic Cells - immunology Dendritic Cells - metabolism Epithelial Cells - immunology Epithelial Cells - metabolism Mice Self Tolerance T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism
Online-Zugang:	Volltext
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