Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is a poorly understood disease that usually leads to death within 5 years of diagnosis. Despite our better understanding of IPF pathogenesis, the etiology and the precise cellular and molecular mechanisms involved are not well known. Current therapies are...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2007-10, Vol.20 (5), p.453-461
Hauptverfasser:	Antoniou, Katerina M, Pataka, Athanasia, Bouros, Demosthenes, Siafakas, Nikolaos M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Apoptosis - drug effects Drug Delivery Systems Epithelial Cells - drug effects Epithelial Cells - pathology Fibroblasts - drug effects Fibroblasts - pathology Humans Idiopathic pulmonary fibrosis treatment Lung - drug effects Lung - physiopathology Medical Education Neovascularization, Pathologic Oligonucleotide Array Sequence Analysis Oxidative stress Oxidative Stress - drug effects Pathogenesis Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - physiopathology Pulmonary/Respiratory T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - pathology
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