Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7‐year‐old child
A 7‐year‐old boy presented with midline swelling in the neck. On fine‐needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two...
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| Veröffentlicht in: | Pathology international 2006-02, Vol.56 (2), p.84-88 |
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| creator | Goyal, Richa Nada, Ritambhra Rao, Katragadda L. N. Radotra, Bishan D. |
| description | A 7‐year‐old boy presented with midline swelling in the neck. On fine‐needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two intermingled components: medullary carcinoma and papillary carcinoma. One of the submandibular lymph nodes had metastasis of both the components. The case was diagnosed as ‘mixed medullary and follicular cell carcinoma’ with papillary carcinoma pattern and lymph node metastasis. Mixed medullary and follicular cell carcinoma with intermingling of medullary and papillary carcinoma components is a rare tumor. In adults, only eight such cases with lymph node metastasis have been published. To the best of the authors’ knowledge no pediatric case has previously been reported in the English‐language literature. |
| doi_str_mv | 10.1111/j.1440-1827.2006.01928.x |
| format | Article |
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N.</creatorcontrib><creatorcontrib>Radotra, Bishan D.</creatorcontrib><title>Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7‐year‐old child</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>A 7‐year‐old boy presented with midline swelling in the neck. On fine‐needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two intermingled components: medullary carcinoma and papillary carcinoma. One of the submandibular lymph nodes had metastasis of both the components. The case was diagnosed as ‘mixed medullary and follicular cell carcinoma’ with papillary carcinoma pattern and lymph node metastasis. Mixed medullary and follicular cell carcinoma with intermingling of medullary and papillary carcinoma components is a rare tumor. In adults, only eight such cases with lymph node metastasis have been published. To the best of the authors’ knowledge no pediatric case has previously been reported in the English‐language literature.</description><subject>Biopsy, Fine-Needle</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Carcinoma, Medullary - chemistry</subject><subject>Carcinoma, Medullary - diagnosis</subject><subject>Carcinoma, Medullary - pathology</subject><subject>Carcinoma, Papillary, Follicular - chemistry</subject><subject>Carcinoma, Papillary, Follicular - diagnosis</subject><subject>Carcinoma, Papillary, Follicular - pathology</subject><subject>Child</subject><subject>composite</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>lymph node metastasis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>medullary carcinoma</subject><subject>Mixed Tumor, Malignant - chemistry</subject><subject>Mixed Tumor, Malignant - diagnosis</subject><subject>Mixed Tumor, Malignant - pathology</subject><subject>papillary carcinoma</subject><subject>Thyroglobulin - analysis</subject><subject>thyroid</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms - chemistry</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9u3CAQxlHVqJtu-woVp9zsDmAb-9BDFTV_pDTJIT0jFsZaVthszFpZ3_IIecY-SXB21VyLBs0gvvlG8yOEMshZOt83OSsKyFjNZc4BqhxYw-t8_4Gc_vv4mGrBISuLSizI5xg3AEyKCj6RBauKoqw5nJLH326PlnZoR-_1MFHdW9oG750Z05sa9J4aPRjXh07T0NLdGtOdhuAsfXK7NfVTt13TPlhMNjsdU7hIXU81lX-fXybUQ0rBW2rWztsv5KTVPuLXY16SPxe_Hs6vspu7y-vznzeZKTjUWS1RV6ythay4qDjDEppytQIuDTfWlAjQtIaLRpfMgkBsC1FoKBkaWTJTiSU5O_huh_A4YtypzsV5Hd1jGKOSIAXU0CRhfRCaIcQ4YKu2g-sSC8VAzbjVRs1U1UxVzbjVG261T63fjjPGVUL43njkmwQ_DoIn53H6b2N1f307V-IVyRaQeA</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Goyal, Richa</creator><creator>Nada, Ritambhra</creator><creator>Rao, Katragadda L. 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N. ; Radotra, Bishan D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4208-87ea61f837623621e5095bb027c2cdc5e009fc239a51d03eef434a051ec751c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biopsy, Fine-Needle</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Carcinoma, Medullary - chemistry</topic><topic>Carcinoma, Medullary - diagnosis</topic><topic>Carcinoma, Medullary - pathology</topic><topic>Carcinoma, Papillary, Follicular - chemistry</topic><topic>Carcinoma, Papillary, Follicular - diagnosis</topic><topic>Carcinoma, Papillary, Follicular - pathology</topic><topic>Child</topic><topic>composite</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>lymph node metastasis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>medullary carcinoma</topic><topic>Mixed Tumor, Malignant - chemistry</topic><topic>Mixed Tumor, Malignant - diagnosis</topic><topic>Mixed Tumor, Malignant - pathology</topic><topic>papillary carcinoma</topic><topic>Thyroglobulin - analysis</topic><topic>thyroid</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Neoplasms - chemistry</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goyal, Richa</creatorcontrib><creatorcontrib>Nada, Ritambhra</creatorcontrib><creatorcontrib>Rao, Katragadda L. N.</creatorcontrib><creatorcontrib>Radotra, Bishan D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goyal, Richa</au><au>Nada, Ritambhra</au><au>Rao, Katragadda L. N.</au><au>Radotra, Bishan D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7‐year‐old child</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2006-02</date><risdate>2006</risdate><volume>56</volume><issue>2</issue><spage>84</spage><epage>88</epage><pages>84-88</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>A 7‐year‐old boy presented with midline swelling in the neck. On fine‐needle aspiration cytology it was diagnosed as papillary carcinoma of the thyroid. The patient underwent total thyroidectomy. Histopathological examination, immunohistochemistry and electron microscopy revealed the presence of two intermingled components: medullary carcinoma and papillary carcinoma. One of the submandibular lymph nodes had metastasis of both the components. The case was diagnosed as ‘mixed medullary and follicular cell carcinoma’ with papillary carcinoma pattern and lymph node metastasis. Mixed medullary and follicular cell carcinoma with intermingling of medullary and papillary carcinoma components is a rare tumor. In adults, only eight such cases with lymph node metastasis have been published. To the best of the authors’ knowledge no pediatric case has previously been reported in the English‐language literature.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>16445820</pmid><doi>10.1111/j.1440-1827.2006.01928.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Biopsy, Fine-Needle Carcinoembryonic Antigen - analysis Carcinoma, Medullary - chemistry Carcinoma, Medullary - diagnosis Carcinoma, Medullary - pathology Carcinoma, Papillary, Follicular - chemistry Carcinoma, Papillary, Follicular - diagnosis Carcinoma, Papillary, Follicular - pathology Child composite Humans Immunohistochemistry lymph node metastasis Lymph Nodes - pathology Lymphatic Metastasis - diagnosis Lymphatic Metastasis - pathology Male medullary carcinoma Mixed Tumor, Malignant - chemistry Mixed Tumor, Malignant - diagnosis Mixed Tumor, Malignant - pathology papillary carcinoma Thyroglobulin - analysis thyroid Thyroid Gland - pathology Thyroid Neoplasms - chemistry Thyroid Neoplasms - diagnosis Thyroid Neoplasms - pathology |
| title | Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7‐year‐old child |
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