Serine racemase binds to PICK1: potential relevance to schizophrenia
Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D -serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for D -serine degradation, such as D -amino acid oxidase and...
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| Veröffentlicht in: | Molecular psychiatry 2006-02, Vol.11 (2), p.150-157 |
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| creator | Fujii, K Maeda, K Hikida, T Mustafa, A K Balkissoon, R Xia, J Yamada, T Ozeki, Y Kawahara, R Okawa, M Huganir, R L Ujike, H Snyder, S H Sawa, A |
| description | Accumulating evidence from both genetic and clinico-pharmacological studies suggests that
D
-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for
D
-serine degradation, such as
D
-amino acid oxidase and G72, has been reported, a role for
D
-serine in SZ has been unclear. In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the
D
-serine synthesizing enzyme, serine racemase (SR). The binding of endogenous PICK1 and SR requires the PDZ domain of PICK1. The gene coding for PICK1 is located at chromosome 22q13, a region frequently linked to SZ. In a case–control association study using well-characterized Japanese subjects, we observe an association of the PICK1 gene with SZ, which is more prominent in disorganized SZ. Our findings implicating PICK1 as a susceptibility gene for SZ are consistent with a role for
D
-serine in the disease. |
| doi_str_mv | 10.1038/sj.mp.4001776 |
| format | Article |
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D
-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for
D
-serine degradation, such as
D
-amino acid oxidase and G72, has been reported, a role for
D
-serine in SZ has been unclear. In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the
D
-serine synthesizing enzyme, serine racemase (SR). The binding of endogenous PICK1 and SR requires the PDZ domain of PICK1. The gene coding for PICK1 is located at chromosome 22q13, a region frequently linked to SZ. In a case–control association study using well-characterized Japanese subjects, we observe an association of the PICK1 gene with SZ, which is more prominent in disorganized SZ. Our findings implicating PICK1 as a susceptibility gene for SZ are consistent with a role for
D
-serine in the disease.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4001776</identifier><identifier>PMID: 16314870</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Amino acid oxidase ; Amino acids ; Animals ; Astrocytes - metabolism ; Behavioral Sciences ; Biological Psychology ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Case-Control Studies ; Chromosome 22 ; D-Amino-acid oxidase ; D-Serine ; Female ; Genetic Predisposition to Disease ; Glutamic acid receptors ; Glutamic acid receptors (ionotropic) ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mental disorders ; Mice ; Middle Aged ; N-Methyl-D-aspartic acid receptors ; Neurosciences ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; original-article ; Pharmacotherapy ; Polymorphism, Single Nucleotide ; Psychiatry ; Racemases and Epimerases - metabolism ; Schizophrenia ; Schizophrenia - classification ; Schizophrenia - enzymology ; Schizophrenia - genetics ; Serine - biosynthesis ; Serine - metabolism ; Serine racemase</subject><ispartof>Molecular psychiatry, 2006-02, Vol.11 (2), p.150-157</ispartof><rights>Springer Nature Limited 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-4015a76ac228e221ce39ef90d3eeb4de6e1af6da54333d0ea5d81ab0e02ac93a3</citedby><cites>FETCH-LOGICAL-c557t-4015a76ac228e221ce39ef90d3eeb4de6e1af6da54333d0ea5d81ab0e02ac93a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4001776$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4001776$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16314870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujii, K</creatorcontrib><creatorcontrib>Maeda, K</creatorcontrib><creatorcontrib>Hikida, T</creatorcontrib><creatorcontrib>Mustafa, A K</creatorcontrib><creatorcontrib>Balkissoon, R</creatorcontrib><creatorcontrib>Xia, J</creatorcontrib><creatorcontrib>Yamada, T</creatorcontrib><creatorcontrib>Ozeki, Y</creatorcontrib><creatorcontrib>Kawahara, R</creatorcontrib><creatorcontrib>Okawa, M</creatorcontrib><creatorcontrib>Huganir, R L</creatorcontrib><creatorcontrib>Ujike, H</creatorcontrib><creatorcontrib>Snyder, S H</creatorcontrib><creatorcontrib>Sawa, A</creatorcontrib><title>Serine racemase binds to PICK1: potential relevance to schizophrenia</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Accumulating evidence from both genetic and clinico-pharmacological studies suggests that
D
-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for
D
-serine degradation, such as
D
-amino acid oxidase and G72, has been reported, a role for
D
-serine in SZ has been unclear. In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the
D
-serine synthesizing enzyme, serine racemase (SR). The binding of endogenous PICK1 and SR requires the PDZ domain of PICK1. The gene coding for PICK1 is located at chromosome 22q13, a region frequently linked to SZ. In a case–control association study using well-characterized Japanese subjects, we observe an association of the PICK1 gene with SZ, which is more prominent in disorganized SZ. Our findings implicating PICK1 as a susceptibility gene for SZ are consistent with a role for
D
-serine in the disease.</description><subject>Adult</subject><subject>Amino acid oxidase</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Astrocytes - metabolism</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Case-Control Studies</subject><subject>Chromosome 22</subject><subject>D-Amino-acid oxidase</subject><subject>D-Serine</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Glutamic acid receptors</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Neurosciences</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychiatry</subject><subject>Racemases and Epimerases - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - classification</subject><subject>Schizophrenia - enzymology</subject><subject>Schizophrenia - genetics</subject><subject>Serine - biosynthesis</subject><subject>Serine - metabolism</subject><subject>Serine racemase</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kd1rFDEUxUNR2rr2sa8ytODbrMnkc_pWtlWLBQX1OdzN3GmzzCRjMivoX2-WLixKJQ8JOb977kkuIeeMLhnl5l3eLMdpKShlWqsjcsqEVrWU2rwoZy7bWjAjTsirnDeFKaI8JidMcSaMpqfk5ismH7BK4HCEjNXahy5Xc6y-3K0-satqijOG2cNQJRzwJwSHOzW7R_87To8Jg4fX5GUPQ8az_b4g39_fflt9rO8_f7hbXd_XrgSaa0GZBK3ANY3BpmEOeYt9SzuOuBYdKmTQqw6k4Jx3FEF2hsGaIm3AtRz4grx98p1S_LHFPNvRZ4fDAAHjNltNNaeUtwW8_AfcxG0KJZttlJBaKmVMoS7-SzWsKZkFO1g9wIDWhz7O5a92fe01M0YKZUrcBVk-Q5XV4ehdDNj7cv9XQf1U4FLMOWFvp-RHSL8so3Y3WJs3dpzsfrCFf7PPul2P2B3o_SQPCXKRwgOmw2Oed_wD6bSrJA</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Fujii, K</creator><creator>Maeda, K</creator><creator>Hikida, T</creator><creator>Mustafa, A K</creator><creator>Balkissoon, R</creator><creator>Xia, J</creator><creator>Yamada, T</creator><creator>Ozeki, Y</creator><creator>Kawahara, R</creator><creator>Okawa, M</creator><creator>Huganir, R L</creator><creator>Ujike, H</creator><creator>Snyder, S H</creator><creator>Sawa, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Serine racemase binds to PICK1: potential relevance to schizophrenia</title><author>Fujii, K ; Maeda, K ; Hikida, T ; Mustafa, A K ; Balkissoon, R ; Xia, J ; Yamada, T ; Ozeki, Y ; Kawahara, R ; Okawa, M ; Huganir, R L ; Ujike, H ; Snyder, S H ; Sawa, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-4015a76ac228e221ce39ef90d3eeb4de6e1af6da54333d0ea5d81ab0e02ac93a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Amino acid oxidase</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Astrocytes - 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Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, K</au><au>Maeda, K</au><au>Hikida, T</au><au>Mustafa, A K</au><au>Balkissoon, R</au><au>Xia, J</au><au>Yamada, T</au><au>Ozeki, Y</au><au>Kawahara, R</au><au>Okawa, M</au><au>Huganir, R L</au><au>Ujike, H</au><au>Snyder, S H</au><au>Sawa, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serine racemase binds to PICK1: potential relevance to schizophrenia</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>11</volume><issue>2</issue><spage>150</spage><epage>157</epage><pages>150-157</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Accumulating evidence from both genetic and clinico-pharmacological studies suggests that
D
-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ). Although an association of genes for
D
-serine degradation, such as
D
-amino acid oxidase and G72, has been reported, a role for
D
-serine in SZ has been unclear. In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the
D
-serine synthesizing enzyme, serine racemase (SR). The binding of endogenous PICK1 and SR requires the PDZ domain of PICK1. The gene coding for PICK1 is located at chromosome 22q13, a region frequently linked to SZ. In a case–control association study using well-characterized Japanese subjects, we observe an association of the PICK1 gene with SZ, which is more prominent in disorganized SZ. Our findings implicating PICK1 as a susceptibility gene for SZ are consistent with a role for
D
-serine in the disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16314870</pmid><doi>10.1038/sj.mp.4001776</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Molecular psychiatry, 2006-02, Vol.11 (2), p.150-157 |
| issn | 1359-4184 1476-5578 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Amino acid oxidase Amino acids Animals Astrocytes - metabolism Behavioral Sciences Biological Psychology Carrier Proteins - genetics Carrier Proteins - metabolism Case-Control Studies Chromosome 22 D-Amino-acid oxidase D-Serine Female Genetic Predisposition to Disease Glutamic acid receptors Glutamic acid receptors (ionotropic) Humans Male Medicine Medicine & Public Health Mental disorders Mice Middle Aged N-Methyl-D-aspartic acid receptors Neurosciences Nuclear Proteins - genetics Nuclear Proteins - metabolism original-article Pharmacotherapy Polymorphism, Single Nucleotide Psychiatry Racemases and Epimerases - metabolism Schizophrenia Schizophrenia - classification Schizophrenia - enzymology Schizophrenia - genetics Serine - biosynthesis Serine - metabolism Serine racemase |
| title | Serine racemase binds to PICK1: potential relevance to schizophrenia |
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