Alloimmunity in primate heart recipients with CD154 blockade : Evidence for alternative costimulation mechanisms

CD154 mediates key facets of humoral and cellular immunity to alloantigens, and is tolerogenic to influenza antigens in primates. Barriers to CD154-based tolerance induction for primate cardiac allografts have not previously been defined. Heterotopic cardiac allograft outcomes in cynomolgus monkeys...

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Veröffentlicht in:	Transplantation 2006-01, Vol.81 (2), p.255-264
Hauptverfasser:	AZIMZADEH, Agnes M, PFEIFFER, Steffen, PIERSON, Richard N, GUOSHENG WU, SCHRÖDER, Carsten, ZORN, George L, KELISHADI, Shahrooz S, OZKAYNAK, Engin, KEHRY, Marilyn, ATKINSON, James B, MILLER, Geraldine G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - pharmacology Antigens, Differentiation, T-Lymphocyte - genetics Antilymphocyte Serum - administration & dosage Biological and medical sciences Bone Marrow Transplantation CD40 Ligand - immunology Cyclosporine - pharmacology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Graft Survival - drug effects Graft Survival - immunology Heart Transplantation - immunology Heart Transplantation - pathology Immunosuppressive Agents - pharmacology Inducible T-Cell Co-Stimulator Protein Isoantibodies - biosynthesis Macaca fascicularis Male Medical sciences Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes - immunology Tissue Donors Tissue, organ and graft immunology Transplantation, Homologous
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