DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells

The high-mobility group (HMG) protein A2 has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipogenesis, leading to a pygmy phenotype with greatly reduced fat tissue in homozygous knock out mice. We showed recently that among the major HMG proteins,...

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Veröffentlicht in:	FEBS letters 2007-07, Vol.581 (18), p.3533-3537
Hauptverfasser:	Li, Ou, Li, Jinming, Dröge, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Biomarkers Cell Differentiation Cell Line Cell Proliferation DNA - genetics DNA architectural protein Down-Regulation Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene Expression Regulation, Developmental - genetics High-mobility group protein HMGA2 Protein - genetics HMGA2 Protein - metabolism Human embryonic stem cells Humans qRT-PCR quantitative reverse transcriptase polymerase chain reaction RNA, Small Interfering - genetics
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