Virulence characteristics of Yersinia pseudotuberculosis isolated from breeding monkeys in Japan
Between April 2001 and 2007, 18 Yersinia pseudotuberculosis outbreaks occurred in breeding monkeys at 12 zoological gardens in Japan, and 28 monkeys of 8 species died. A total of 18 Y. pseudotuberculosis strains from the dead monkeys, comprising one strain per outbreak, were examined for serotype an...
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| Veröffentlicht in: | Veterinary microbiology 2008-06, Vol.129 (3), p.404-409 |
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| creator | Iwata, Taketoshi Une, Yumi Okatani, Alexandre Tomomitsu Kato, Yukio Nakadai, Aya Lee, Ken-Ichi Watanabe, Maiko Taniguchi, Takahide Elhelaly, AbdelAzim Elsayed Hirota, Yoshikazu Hayashidani, Hideki |
| description | Between April 2001 and 2007, 18
Yersinia pseudotuberculosis outbreaks occurred in breeding monkeys at 12 zoological gardens in Japan, and 28 monkeys of 8 species died. A total of 18
Y. pseudotuberculosis strains from the dead monkeys, comprising one strain per outbreak, were examined for serotype and the presence of the virulence genes
virF,
inv,
ypm (
ypmA,
ypmB and
ypmC) and
irp2. Of the 18
Y. pseudotuberculosis strains, 7 (38.9%) were serotype 4b, 7 (38.9%) were serotype 1b, and there was one each of serotypes 2b, 3, 6 and 7. All the 18 strains examined harbored
virF and
inv. Sixteen (88.9%) strains, including the strain of serotype 7, harbored
ypmA. However, no strain harbored
ypmB,
ypmC and
irp2.
This study demonstrated that among other pathogenic factors, almost all the
Y. pseudotuberculosis isolated from the outbreaks had the
ypm gene encoding the superantigenic toxin, YPM. As most of the monkeys who died in those outbreaks originated from South America and other regions, where the presence of the
ypm gene have not been reported, YPM might be the cause, or at least the most important factor for, the high mortality of the breeding monkeys infected by
Y. pseudotuberculosis in Japan. This is also the first report of a fatal case due to
Y. pseudotuberculosis serotype 7 infection in the world. |
| doi_str_mv | 10.1016/j.vetmic.2007.11.029 |
| format | Article |
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Yersinia pseudotuberculosis outbreaks occurred in breeding monkeys at 12 zoological gardens in Japan, and 28 monkeys of 8 species died. A total of 18
Y. pseudotuberculosis strains from the dead monkeys, comprising one strain per outbreak, were examined for serotype and the presence of the virulence genes
virF,
inv,
ypm (
ypmA,
ypmB and
ypmC) and
irp2. Of the 18
Y. pseudotuberculosis strains, 7 (38.9%) were serotype 4b, 7 (38.9%) were serotype 1b, and there was one each of serotypes 2b, 3, 6 and 7. All the 18 strains examined harbored
virF and
inv. Sixteen (88.9%) strains, including the strain of serotype 7, harbored
ypmA. However, no strain harbored
ypmB,
ypmC and
irp2.
This study demonstrated that among other pathogenic factors, almost all the
Y. pseudotuberculosis isolated from the outbreaks had the
ypm gene encoding the superantigenic toxin, YPM. As most of the monkeys who died in those outbreaks originated from South America and other regions, where the presence of the
ypm gene have not been reported, YPM might be the cause, or at least the most important factor for, the high mortality of the breeding monkeys infected by
Y. pseudotuberculosis in Japan. This is also the first report of a fatal case due to
Y. pseudotuberculosis serotype 7 infection in the world.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/j.vetmic.2007.11.029</identifier><identifier>PMID: 18242014</identifier><identifier>CODEN: VMICDQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>animal breeding ; Animals ; Animals, Zoo ; bacterial infections ; Bacterial Proteins - genetics ; Bacteriology ; Biological and medical sciences ; Breeding monkey ; disease outbreaks ; Disease Outbreaks - veterinary ; Female ; Fundamental and applied biological sciences. Psychology ; genes ; Haplorhini ; isolation ; Japan - epidemiology ; Male ; Microbiology ; Miscellaneous ; Monkey Diseases - epidemiology ; Monkey Diseases - microbiology ; monkeys ; pathogenicity ; serotypes ; Serotyping ; Species Specificity ; strain differences ; strains ; virulence ; Virulence - genetics ; Virulence Factors - genetics ; Virulence genes ; Yersinia pseudotuberculosis ; Yersinia pseudotuberculosis - classification ; Yersinia pseudotuberculosis - genetics ; Yersinia pseudotuberculosis - pathogenicity ; Yersinia pseudotuberculosis Infections - epidemiology ; Yersinia pseudotuberculosis Infections - microbiology ; Yersinia pseudotuberculosis Infections - veterinary ; Yersinia pseudotuberculosis serotype 7 ; YPM</subject><ispartof>Veterinary microbiology, 2008-06, Vol.129 (3), p.404-409</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-ecca5234504d8c4f6c31633a02df35b1b3d3ffe7b7e9d99bdc0fb9a36ed79c813</citedby><cites>FETCH-LOGICAL-c511t-ecca5234504d8c4f6c31633a02df35b1b3d3ffe7b7e9d99bdc0fb9a36ed79c813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetmic.2007.11.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20361904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18242014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwata, Taketoshi</creatorcontrib><creatorcontrib>Une, Yumi</creatorcontrib><creatorcontrib>Okatani, Alexandre Tomomitsu</creatorcontrib><creatorcontrib>Kato, Yukio</creatorcontrib><creatorcontrib>Nakadai, Aya</creatorcontrib><creatorcontrib>Lee, Ken-Ichi</creatorcontrib><creatorcontrib>Watanabe, Maiko</creatorcontrib><creatorcontrib>Taniguchi, Takahide</creatorcontrib><creatorcontrib>Elhelaly, AbdelAzim Elsayed</creatorcontrib><creatorcontrib>Hirota, Yoshikazu</creatorcontrib><creatorcontrib>Hayashidani, Hideki</creatorcontrib><title>Virulence characteristics of Yersinia pseudotuberculosis isolated from breeding monkeys in Japan</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>Between April 2001 and 2007, 18
Yersinia pseudotuberculosis outbreaks occurred in breeding monkeys at 12 zoological gardens in Japan, and 28 monkeys of 8 species died. A total of 18
Y. pseudotuberculosis strains from the dead monkeys, comprising one strain per outbreak, were examined for serotype and the presence of the virulence genes
virF,
inv,
ypm (
ypmA,
ypmB and
ypmC) and
irp2. Of the 18
Y. pseudotuberculosis strains, 7 (38.9%) were serotype 4b, 7 (38.9%) were serotype 1b, and there was one each of serotypes 2b, 3, 6 and 7. All the 18 strains examined harbored
virF and
inv. Sixteen (88.9%) strains, including the strain of serotype 7, harbored
ypmA. However, no strain harbored
ypmB,
ypmC and
irp2.
This study demonstrated that among other pathogenic factors, almost all the
Y. pseudotuberculosis isolated from the outbreaks had the
ypm gene encoding the superantigenic toxin, YPM. As most of the monkeys who died in those outbreaks originated from South America and other regions, where the presence of the
ypm gene have not been reported, YPM might be the cause, or at least the most important factor for, the high mortality of the breeding monkeys infected by
Y. pseudotuberculosis in Japan. This is also the first report of a fatal case due to
Y. pseudotuberculosis serotype 7 infection in the world.</description><subject>animal breeding</subject><subject>Animals</subject><subject>Animals, Zoo</subject><subject>bacterial infections</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Breeding monkey</subject><subject>disease outbreaks</subject><subject>Disease Outbreaks - veterinary</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genes</subject><subject>Haplorhini</subject><subject>isolation</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Monkey Diseases - epidemiology</subject><subject>Monkey Diseases - microbiology</subject><subject>monkeys</subject><subject>pathogenicity</subject><subject>serotypes</subject><subject>Serotyping</subject><subject>Species Specificity</subject><subject>strain differences</subject><subject>strains</subject><subject>virulence</subject><subject>Virulence - genetics</subject><subject>Virulence Factors - genetics</subject><subject>Virulence genes</subject><subject>Yersinia pseudotuberculosis</subject><subject>Yersinia pseudotuberculosis - classification</subject><subject>Yersinia pseudotuberculosis - genetics</subject><subject>Yersinia pseudotuberculosis - pathogenicity</subject><subject>Yersinia pseudotuberculosis Infections - epidemiology</subject><subject>Yersinia pseudotuberculosis Infections - microbiology</subject><subject>Yersinia pseudotuberculosis Infections - veterinary</subject><subject>Yersinia pseudotuberculosis serotype 7</subject><subject>YPM</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhHyDIBW5ZZux8-YKEKj5ViQMUiZNx7HHxksRbO6nUf4-jrOAGpznMM69G78PYU4Q9AjavDvtbmkdv9hyg3SPugct7bIddK0peV_w-24FouxJR1GfsUUoHAKhkAw_ZGXa84oDVjv345uMy0GSoMD911Gam6NPsTSqCK75TTH7yujgmWmyYl56iWYaQfCp8CoOeyRYuhrHoI5H103UxhukX3eX1VHzSRz09Zg-cHhI9Oc1zdvXu7deLD-Xl5_cfL95clqZGnEsyRtdcVDVUtjOVa4zARggN3DpR99gLK5yjtm9JWil7a8D1UouGbCtNh-KcvdxyjzHcLJRmNfpkaBj0RGFJqoWWd239fxBll3sSK1htoIkhpUhOHaMfdbxTCGpVoA5qU6BWBQpRZQX57Nkpf-lHsn-PTp1n4MUJ0MnowUU9GZ_-cBxEgxJW7vnGOR2Uvs5a1NWXnCAAOplLqzPxeiMoF3vrKapk_OrS-khmVjb4f__6G71Nsd4</recordid><startdate>20080622</startdate><enddate>20080622</enddate><creator>Iwata, Taketoshi</creator><creator>Une, Yumi</creator><creator>Okatani, Alexandre Tomomitsu</creator><creator>Kato, Yukio</creator><creator>Nakadai, Aya</creator><creator>Lee, Ken-Ichi</creator><creator>Watanabe, Maiko</creator><creator>Taniguchi, Takahide</creator><creator>Elhelaly, AbdelAzim Elsayed</creator><creator>Hirota, Yoshikazu</creator><creator>Hayashidani, Hideki</creator><general>Elsevier B.V</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20080622</creationdate><title>Virulence characteristics of Yersinia pseudotuberculosis isolated from breeding monkeys in Japan</title><author>Iwata, Taketoshi ; Une, Yumi ; Okatani, Alexandre Tomomitsu ; Kato, Yukio ; Nakadai, Aya ; Lee, Ken-Ichi ; Watanabe, Maiko ; Taniguchi, Takahide ; Elhelaly, AbdelAzim Elsayed ; Hirota, Yoshikazu ; Hayashidani, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-ecca5234504d8c4f6c31633a02df35b1b3d3ffe7b7e9d99bdc0fb9a36ed79c813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal breeding</topic><topic>Animals</topic><topic>Animals, Zoo</topic><topic>bacterial infections</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Breeding monkey</topic><topic>disease outbreaks</topic><topic>Disease Outbreaks - veterinary</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genes</topic><topic>Haplorhini</topic><topic>isolation</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Monkey Diseases - epidemiology</topic><topic>Monkey Diseases - microbiology</topic><topic>monkeys</topic><topic>pathogenicity</topic><topic>serotypes</topic><topic>Serotyping</topic><topic>Species Specificity</topic><topic>strain differences</topic><topic>strains</topic><topic>virulence</topic><topic>Virulence - genetics</topic><topic>Virulence Factors - genetics</topic><topic>Virulence genes</topic><topic>Yersinia pseudotuberculosis</topic><topic>Yersinia pseudotuberculosis - classification</topic><topic>Yersinia pseudotuberculosis - genetics</topic><topic>Yersinia pseudotuberculosis - pathogenicity</topic><topic>Yersinia pseudotuberculosis Infections - epidemiology</topic><topic>Yersinia pseudotuberculosis Infections - microbiology</topic><topic>Yersinia pseudotuberculosis Infections - veterinary</topic><topic>Yersinia pseudotuberculosis serotype 7</topic><topic>YPM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwata, Taketoshi</creatorcontrib><creatorcontrib>Une, Yumi</creatorcontrib><creatorcontrib>Okatani, Alexandre Tomomitsu</creatorcontrib><creatorcontrib>Kato, Yukio</creatorcontrib><creatorcontrib>Nakadai, Aya</creatorcontrib><creatorcontrib>Lee, Ken-Ichi</creatorcontrib><creatorcontrib>Watanabe, Maiko</creatorcontrib><creatorcontrib>Taniguchi, Takahide</creatorcontrib><creatorcontrib>Elhelaly, AbdelAzim Elsayed</creatorcontrib><creatorcontrib>Hirota, Yoshikazu</creatorcontrib><creatorcontrib>Hayashidani, Hideki</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwata, Taketoshi</au><au>Une, Yumi</au><au>Okatani, Alexandre Tomomitsu</au><au>Kato, Yukio</au><au>Nakadai, Aya</au><au>Lee, Ken-Ichi</au><au>Watanabe, Maiko</au><au>Taniguchi, Takahide</au><au>Elhelaly, AbdelAzim Elsayed</au><au>Hirota, Yoshikazu</au><au>Hayashidani, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virulence characteristics of Yersinia pseudotuberculosis isolated from breeding monkeys in Japan</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2008-06-22</date><risdate>2008</risdate><volume>129</volume><issue>3</issue><spage>404</spage><epage>409</epage><pages>404-409</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>Between April 2001 and 2007, 18
Yersinia pseudotuberculosis outbreaks occurred in breeding monkeys at 12 zoological gardens in Japan, and 28 monkeys of 8 species died. A total of 18
Y. pseudotuberculosis strains from the dead monkeys, comprising one strain per outbreak, were examined for serotype and the presence of the virulence genes
virF,
inv,
ypm (
ypmA,
ypmB and
ypmC) and
irp2. Of the 18
Y. pseudotuberculosis strains, 7 (38.9%) were serotype 4b, 7 (38.9%) were serotype 1b, and there was one each of serotypes 2b, 3, 6 and 7. All the 18 strains examined harbored
virF and
inv. Sixteen (88.9%) strains, including the strain of serotype 7, harbored
ypmA. However, no strain harbored
ypmB,
ypmC and
irp2.
This study demonstrated that among other pathogenic factors, almost all the
Y. pseudotuberculosis isolated from the outbreaks had the
ypm gene encoding the superantigenic toxin, YPM. As most of the monkeys who died in those outbreaks originated from South America and other regions, where the presence of the
ypm gene have not been reported, YPM might be the cause, or at least the most important factor for, the high mortality of the breeding monkeys infected by
Y. pseudotuberculosis in Japan. This is also the first report of a fatal case due to
Y. pseudotuberculosis serotype 7 infection in the world.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18242014</pmid><doi>10.1016/j.vetmic.2007.11.029</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Veterinary microbiology, 2008-06, Vol.129 (3), p.404-409 |
| issn | 0378-1135 1873-2542 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70728751 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | animal breeding Animals Animals, Zoo bacterial infections Bacterial Proteins - genetics Bacteriology Biological and medical sciences Breeding monkey disease outbreaks Disease Outbreaks - veterinary Female Fundamental and applied biological sciences. Psychology genes Haplorhini isolation Japan - epidemiology Male Microbiology Miscellaneous Monkey Diseases - epidemiology Monkey Diseases - microbiology monkeys pathogenicity serotypes Serotyping Species Specificity strain differences strains virulence Virulence - genetics Virulence Factors - genetics Virulence genes Yersinia pseudotuberculosis Yersinia pseudotuberculosis - classification Yersinia pseudotuberculosis - genetics Yersinia pseudotuberculosis - pathogenicity Yersinia pseudotuberculosis Infections - epidemiology Yersinia pseudotuberculosis Infections - microbiology Yersinia pseudotuberculosis Infections - veterinary Yersinia pseudotuberculosis serotype 7 YPM |
| title | Virulence characteristics of Yersinia pseudotuberculosis isolated from breeding monkeys in Japan |
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