Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions

Intrathymic Notch1 signaling critically regulates T‐lineage specification and commitment as well as T‐cell progenitor survival and differentiation. Notch1 activation is continuously required during progression of early CD4/CD8‐double‐negative thymocytes to the CD4/CD8‐double‐positive stage. This dev...

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Veröffentlicht in:	Immunological reviews 2006-02, Vol.209 (1), p.76-94
Hauptverfasser:	Visan, Ioana, Yuan, Julie S., Tan, Joanne B., Cretegny, Kira, Guidos, Cynthia J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - metabolism Cell Lineage Glycosyltransferases - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Intercellular Signaling Peptides and Proteins - metabolism Jagged-1 Protein Lymphopoiesis Membrane Proteins - metabolism Mice Models, Immunological Organ Size Receptor, Notch1 - metabolism Repressor Proteins - metabolism Serrate-Jagged Proteins Signal Transduction T-Lymphocytes - cytology T-Lymphocytes - metabolism Thymus Gland - cytology Thymus Gland - growth & development Thymus Gland - metabolism
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