The Disease Progression of Mecp2 Mutant Mice Is Affected by the Level of BDNF Expression

Mutations in the MECP2 gene cause Rett syndrome (RTT). Bdnf is a MeCP2 target gene; however, its role in RTT pathogenesis is unknown. We examined Bdnf conditional mutant mice for RTT-relevant pathologies and observed that loss of BDNF caused smaller brain size, smaller CA2 neurons, smaller glomerulu...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2006-02, Vol.49 (3), p.341-348
Hauptverfasser:	Chang, Qiang, Khare, Gargi, Dani, Vardhan, Nelson, Sacha, Jaenisch, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - genetics Action Potentials - radiation effects Age Animals Animals, Newborn Behavior, Animal Brain Brain - metabolism Brain - pathology Brain research Brain-Derived Neurotrophic Factor - deficiency Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism DEVBIO Disease Models, Animal Disease Progression DNA methylation Electric Stimulation - methods Enzyme-Linked Immunosorbent Assay - methods Female Gene Expression Regulation - genetics Genetic engineering Humans Immunohistochemistry - methods In Vitro Techniques Male Methyl-CpG-Binding Protein 2 - deficiency Methyl-CpG-Binding Protein 2 - genetics Mice Mice, Knockout MOLNEURO Motor Activity - genetics Mutation - physiology Neurons Neurons - physiology Organ Size - genetics Patch-Clamp Techniques - methods Proteins Rett Syndrome - genetics Rett Syndrome - metabolism Rett Syndrome - physiopathology Reverse Transcriptase Polymerase Chain Reaction - methods RNA RNA, Messenger - metabolism Rodents Social research Software Studies
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