Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States
BACKGROUND: Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life‐long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2006-02, Vol.46 (2), p.298-304 |
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| creator | Kirchhoff, Louis V. Paredes, Patricia Lomelí-Guerrero, Abel Paredes-Espinoza, Mario Ron-Guerrero, Carlos S. Delgado-Mejía, Manuel Peña-Muñoz, José G. |
| description | BACKGROUND: Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life‐long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by transfusion, and to evaluate two serologic assays for Chagas disease.
STUDY DESIGN and METHODS: Blood samples from donors were tested initially with the Abbott Chagas EIA or the Meridian Chagas’ IgG ELISA. Samples giving readings that were at least 50% of the cutoffs were run in a confirmatory radioimmune precipitation assay (RIPA), as were samples from recipients of blood products from RIPA‐positive donors.
RESULTS: The overall prevalence of Chagas disease was 1/133 (55/7,296; 0.75%). In addition, 4 of 9 surviving recipients of blood products from T. cruzi‐infected donors were in turn infected. Using the manufacturers’ recommended cutoffs, the sensitivity and specificity of the Abbott test were 92.0% (23/25) and 99.8% (2,865/2,872) respectively, and the corresponding values for the Meridian assay were 70.0% (21/30) and 100.0% (4,369/4,369).
CONCLUSIONS: These findings indicate clearly that transfusion‐associated transmission of T. cruzi is occurring in the study areas. Serologic testing of blood donors for Chagas disease should be performed there and in the rest of Mexico. The two screening assays evaluated may lack the accuracy necessary for blood donor testing when used as suggested by the manufacturers. |
| doi_str_mv | 10.1111/j.1537-2995.2006.00715.x |
| format | Article |
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STUDY DESIGN and METHODS: Blood samples from donors were tested initially with the Abbott Chagas EIA or the Meridian Chagas’ IgG ELISA. Samples giving readings that were at least 50% of the cutoffs were run in a confirmatory radioimmune precipitation assay (RIPA), as were samples from recipients of blood products from RIPA‐positive donors.
RESULTS: The overall prevalence of Chagas disease was 1/133 (55/7,296; 0.75%). In addition, 4 of 9 surviving recipients of blood products from T. cruzi‐infected donors were in turn infected. Using the manufacturers’ recommended cutoffs, the sensitivity and specificity of the Abbott test were 92.0% (23/25) and 99.8% (2,865/2,872) respectively, and the corresponding values for the Meridian assay were 70.0% (21/30) and 100.0% (4,369/4,369).
CONCLUSIONS: These findings indicate clearly that transfusion‐associated transmission of T. cruzi is occurring in the study areas. Serologic testing of blood donors for Chagas disease should be performed there and in the rest of Mexico. The two screening assays evaluated may lack the accuracy necessary for blood donor testing when used as suggested by the manufacturers.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2006.00715.x</identifier><identifier>PMID: 16441610</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Science Inc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Blood Transfusion - statistics & numerical data ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Chagas Disease - blood ; Chagas Disease - epidemiology ; Chagas Disease - transmission ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Endemic Diseases - statistics & numerical data ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Intensive care medicine ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Mass Screening ; Medical sciences ; Mexico - epidemiology ; Middle Aged ; Prevalence ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Respiratory system ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Trypanosoma cruzi - isolation & purification ; United States - ethnology</subject><ispartof>Transfusion (Philadelphia, Pa.), 2006-02, Vol.46 (2), p.298-304</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5025-ee0fb23fb88ad3db74ace7a380f29555b1b498197ab1d3e34d358e59f2bffab63</citedby><cites>FETCH-LOGICAL-c5025-ee0fb23fb88ad3db74ace7a380f29555b1b498197ab1d3e34d358e59f2bffab63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2006.00715.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2006.00715.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17528430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16441610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirchhoff, Louis V.</creatorcontrib><creatorcontrib>Paredes, Patricia</creatorcontrib><creatorcontrib>Lomelí-Guerrero, Abel</creatorcontrib><creatorcontrib>Paredes-Espinoza, Mario</creatorcontrib><creatorcontrib>Ron-Guerrero, Carlos S.</creatorcontrib><creatorcontrib>Delgado-Mejía, Manuel</creatorcontrib><creatorcontrib>Peña-Muñoz, José G.</creatorcontrib><title>Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life‐long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by transfusion, and to evaluate two serologic assays for Chagas disease.
STUDY DESIGN and METHODS: Blood samples from donors were tested initially with the Abbott Chagas EIA or the Meridian Chagas’ IgG ELISA. Samples giving readings that were at least 50% of the cutoffs were run in a confirmatory radioimmune precipitation assay (RIPA), as were samples from recipients of blood products from RIPA‐positive donors.
RESULTS: The overall prevalence of Chagas disease was 1/133 (55/7,296; 0.75%). In addition, 4 of 9 surviving recipients of blood products from T. cruzi‐infected donors were in turn infected. Using the manufacturers’ recommended cutoffs, the sensitivity and specificity of the Abbott test were 92.0% (23/25) and 99.8% (2,865/2,872) respectively, and the corresponding values for the Meridian assay were 70.0% (21/30) and 100.0% (4,369/4,369).
CONCLUSIONS: These findings indicate clearly that transfusion‐associated transmission of T. cruzi is occurring in the study areas. Serologic testing of blood donors for Chagas disease should be performed there and in the rest of Mexico. The two screening assays evaluated may lack the accuracy necessary for blood donor testing when used as suggested by the manufacturers.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion - statistics & numerical data</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Chagas Disease - blood</subject><subject>Chagas Disease - epidemiology</subject><subject>Chagas Disease - transmission</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Endemic Diseases - statistics & numerical data</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Respiratory system</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Trypanosoma cruzi - isolation & purification</subject><subject>United States - ethnology</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhS0EYsrAKyBvQLBI8U8cJyyQRhVTkApITEcsLce5ZlzyU3xT0b4Az40zrTpbvLElf-cc-1xCKGdznta7zZwrqTNRVWouGCvmjGmu5vtHZHa-eExmjOU841yKC_IMccMYExXjT8kFL_KcF5zNyN91tD36HYahzyzi4IIdoaGLO_vTIm0CgkWgb646iMHZno7xsLX9gEMXLAZ8S0NPv8A-uOE9Dd22TdCYvJD6ISb4bE47aIILPUyC8Q7obR-moJsx5eFz8sTbFuHFab8kt9cf14tP2erb8vPiapU5xYTKAJivhfR1WdpGNrXOrQNtZcm8qJRSNa_zquSVtjVvJMi8kaoEVXlRe2_rQl6S10ffbRx-7wBH0wV00La2h2GHRjMtVJ5PYHkEXRwQI3izjaGz8WA4M9MMzMZMVZupajPNwNzPwOyT9OUpY1enTz8IT6Un4NUJsOhs61NJLuADp5UoczlxH47cn9DC4b8fYNbfr--PySA7GgQcYX82sPGXKbTUyvz4ujQFq1bqpizNUv4Dxyu0dw</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Kirchhoff, Louis V.</creator><creator>Paredes, Patricia</creator><creator>Lomelí-Guerrero, Abel</creator><creator>Paredes-Espinoza, Mario</creator><creator>Ron-Guerrero, Carlos S.</creator><creator>Delgado-Mejía, Manuel</creator><creator>Peña-Muñoz, José G.</creator><general>Blackwell Science Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States</title><author>Kirchhoff, Louis V. ; Paredes, Patricia ; Lomelí-Guerrero, Abel ; Paredes-Espinoza, Mario ; Ron-Guerrero, Carlos S. ; Delgado-Mejía, Manuel ; Peña-Muñoz, José G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5025-ee0fb23fb88ad3db74ace7a380f29555b1b498197ab1d3e34d358e59f2bffab63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion - statistics & numerical data</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Chagas Disease - blood</topic><topic>Chagas Disease - epidemiology</topic><topic>Chagas Disease - transmission</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Endemic Diseases - statistics & numerical data</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Respiratory system</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Trypanosoma cruzi - isolation & purification</topic><topic>United States - ethnology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirchhoff, Louis V.</creatorcontrib><creatorcontrib>Paredes, Patricia</creatorcontrib><creatorcontrib>Lomelí-Guerrero, Abel</creatorcontrib><creatorcontrib>Paredes-Espinoza, Mario</creatorcontrib><creatorcontrib>Ron-Guerrero, Carlos S.</creatorcontrib><creatorcontrib>Delgado-Mejía, Manuel</creatorcontrib><creatorcontrib>Peña-Muñoz, José G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirchhoff, Louis V.</au><au>Paredes, Patricia</au><au>Lomelí-Guerrero, Abel</au><au>Paredes-Espinoza, Mario</au><au>Ron-Guerrero, Carlos S.</au><au>Delgado-Mejía, Manuel</au><au>Peña-Muñoz, José G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2006-02</date><risdate>2006</risdate><volume>46</volume><issue>2</issue><spage>298</spage><epage>304</epage><pages>298-304</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life‐long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by transfusion, and to evaluate two serologic assays for Chagas disease.
STUDY DESIGN and METHODS: Blood samples from donors were tested initially with the Abbott Chagas EIA or the Meridian Chagas’ IgG ELISA. Samples giving readings that were at least 50% of the cutoffs were run in a confirmatory radioimmune precipitation assay (RIPA), as were samples from recipients of blood products from RIPA‐positive donors.
RESULTS: The overall prevalence of Chagas disease was 1/133 (55/7,296; 0.75%). In addition, 4 of 9 surviving recipients of blood products from T. cruzi‐infected donors were in turn infected. Using the manufacturers’ recommended cutoffs, the sensitivity and specificity of the Abbott test were 92.0% (23/25) and 99.8% (2,865/2,872) respectively, and the corresponding values for the Meridian assay were 70.0% (21/30) and 100.0% (4,369/4,369).
CONCLUSIONS: These findings indicate clearly that transfusion‐associated transmission of T. cruzi is occurring in the study areas. Serologic testing of blood donors for Chagas disease should be performed there and in the rest of Mexico. The two screening assays evaluated may lack the accuracy necessary for blood donor testing when used as suggested by the manufacturers.</abstract><cop>Malden, USA</cop><pub>Blackwell Science Inc</pub><pmid>16441610</pmid><doi>10.1111/j.1537-2995.2006.00715.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Transfusion - statistics & numerical data Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Chagas Disease - blood Chagas Disease - epidemiology Chagas Disease - transmission Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Endemic Diseases - statistics & numerical data Enzyme-Linked Immunosorbent Assay Female Humans Intensive care medicine Investigative techniques, diagnostic techniques (general aspects) Male Mass Screening Medical sciences Mexico - epidemiology Middle Aged Prevalence Radiodiagnosis. Nmr imagery. Nmr spectrometry Respiratory system Transfusions. Complications. Transfusion reactions. Cell and gene therapy Trypanosoma cruzi - isolation & purification United States - ethnology |
| title | Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States |
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