Family history of stroke does not predict risk of stroke after transient ischemic attack
Animal models suggest a genetic contribution to cerebral susceptibility to ischemia. Family history of stroke (FHxstroke) is a risk factor for ischemic stroke, but there is significant confounding by heritability of hypertension and other intermediate phenotypes, and it is uncertain whether genetic...
Gespeichert in:
| Veröffentlicht in: | Stroke (1970) 2006-02, Vol.37 (2), p.544-546 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 546 |
|---|---|
| container_issue | 2 |
| container_start_page | 544 |
| container_title | Stroke (1970) |
| container_volume | 37 |
| creator | FLOSSMANN, Enrico ROTHWELL, Peter M |
| description | Animal models suggest a genetic contribution to cerebral susceptibility to ischemia. Family history of stroke (FHxstroke) is a risk factor for ischemic stroke, but there is significant confounding by heritability of hypertension and other intermediate phenotypes, and it is uncertain whether genetic factors have a direct independent influence on cerebral susceptibility to ischemia in man.
We related detailed FHxstroke to baseline characteristics and subsequent risk of stroke in 2 population-based incidence studies and a consecutive hospital-referred series of patients with recent transient ischemic attack (TIA).
In none of the cohorts or the pooled data (757 patients; 5515 patient years follow-up; 200 ischemic strokes; 126 myocardial infarctions [MIs]) did FHxstroke predict ischemic stroke (odds ratio [OR], 0.87; 95% CI, 0.57 to 1.32). No associations were revealed by analyses stratified by age or hypertension in the proband, FHx(stroke) in parents versus siblings, number of affected relatives, or their age at stroke. FHxstroke was unrelated to presence of ischemic lesions on baseline computed tomography (OR, 0.96; 0.52 to 1.76) or risk of MI during follow-up. There was no bias attributable to any relationship between FHxstroke and risk factor control or medication.
Family history of stroke does not predict risk of ischemic stroke after TIA. |
| doi_str_mv | 10.1161/01.STR.0000198879.11072.f2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70725063</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70725063</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-c8aad9304e311ad878a144bf2a0b2c952a498b3598233970153990e64ee19e813</originalsourceid><addsrcrecordid>eNpNkV1LwzAUhoMobk7_ggRB7zrz1TbxToZTYSDoBO9Cmp6yuHadSXaxf2_Uwjw3L5w8Jyc8QeiKkimlBb0ldPq2fJ2SVFRJWarUJiWbNuwIjWnORCYKJo_RmBCuMiaUGqGzED4Tz7jMT9GIFimJVGP0MTeda_d45ULs_R73DQ7R92vAdQ8Bb_qItx5qZyP2Lqz_nZsmgsfRm01wsInYBbuCzllsYjR2fY5OGtMGuBhygt7nD8vZU7Z4eXye3S8yK7iImZXG1IoTAZxSU8tSGipE1TBDKmZVzoxQsuK5koxzVRKac6UIFAKAKpCUT9DN371b33_tIETdpZdA25oN9Lugy2QmJwVP4N0faH0fgodGb73rjN9rSvSPV02oTl71wav-9aobloYvhy27qoP6MDqITMD1AJhgTdskLdaFA1cWpMjTf3wD4WSBTA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70725063</pqid></control><display><type>article</type><title>Family history of stroke does not predict risk of stroke after transient ischemic attack</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>FLOSSMANN, Enrico ; ROTHWELL, Peter M</creator><creatorcontrib>FLOSSMANN, Enrico ; ROTHWELL, Peter M</creatorcontrib><description>Animal models suggest a genetic contribution to cerebral susceptibility to ischemia. Family history of stroke (FHxstroke) is a risk factor for ischemic stroke, but there is significant confounding by heritability of hypertension and other intermediate phenotypes, and it is uncertain whether genetic factors have a direct independent influence on cerebral susceptibility to ischemia in man.
We related detailed FHxstroke to baseline characteristics and subsequent risk of stroke in 2 population-based incidence studies and a consecutive hospital-referred series of patients with recent transient ischemic attack (TIA).
In none of the cohorts or the pooled data (757 patients; 5515 patient years follow-up; 200 ischemic strokes; 126 myocardial infarctions [MIs]) did FHxstroke predict ischemic stroke (odds ratio [OR], 0.87; 95% CI, 0.57 to 1.32). No associations were revealed by analyses stratified by age or hypertension in the proband, FHx(stroke) in parents versus siblings, number of affected relatives, or their age at stroke. FHxstroke was unrelated to presence of ischemic lesions on baseline computed tomography (OR, 0.96; 0.52 to 1.76) or risk of MI during follow-up. There was no bias attributable to any relationship between FHxstroke and risk factor control or medication.
Family history of stroke does not predict risk of ischemic stroke after TIA.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000198879.11072.f2</identifier><identifier>PMID: 16385089</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain Ischemia - pathology ; Cohort Studies ; Disease-Free Survival ; Family Health ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Ischemic Attack, Transient - complications ; Ischemic Attack, Transient - genetics ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - diagnosis ; Myocardial Infarction - genetics ; Nervous system (semeiology, syndromes) ; Neurology ; Odds Ratio ; Pharmacology. Drug treatments ; Phenotype ; Prognosis ; Risk ; Risk Factors ; Stroke - diagnosis ; Stroke - genetics ; Time Factors ; Tomography, X-Ray Computed ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2006-02, Vol.37 (2), p.544-546</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-c8aad9304e311ad878a144bf2a0b2c952a498b3598233970153990e64ee19e813</citedby><cites>FETCH-LOGICAL-c434t-c8aad9304e311ad878a144bf2a0b2c952a498b3598233970153990e64ee19e813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17606500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16385089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FLOSSMANN, Enrico</creatorcontrib><creatorcontrib>ROTHWELL, Peter M</creatorcontrib><title>Family history of stroke does not predict risk of stroke after transient ischemic attack</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Animal models suggest a genetic contribution to cerebral susceptibility to ischemia. Family history of stroke (FHxstroke) is a risk factor for ischemic stroke, but there is significant confounding by heritability of hypertension and other intermediate phenotypes, and it is uncertain whether genetic factors have a direct independent influence on cerebral susceptibility to ischemia in man.
We related detailed FHxstroke to baseline characteristics and subsequent risk of stroke in 2 population-based incidence studies and a consecutive hospital-referred series of patients with recent transient ischemic attack (TIA).
In none of the cohorts or the pooled data (757 patients; 5515 patient years follow-up; 200 ischemic strokes; 126 myocardial infarctions [MIs]) did FHxstroke predict ischemic stroke (odds ratio [OR], 0.87; 95% CI, 0.57 to 1.32). No associations were revealed by analyses stratified by age or hypertension in the proband, FHx(stroke) in parents versus siblings, number of affected relatives, or their age at stroke. FHxstroke was unrelated to presence of ischemic lesions on baseline computed tomography (OR, 0.96; 0.52 to 1.76) or risk of MI during follow-up. There was no bias attributable to any relationship between FHxstroke and risk factor control or medication.
Family history of stroke does not predict risk of ischemic stroke after TIA.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain Ischemia - pathology</subject><subject>Cohort Studies</subject><subject>Disease-Free Survival</subject><subject>Family Health</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - complications</subject><subject>Ischemic Attack, Transient - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - genetics</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Stroke - diagnosis</subject><subject>Stroke - genetics</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkV1LwzAUhoMobk7_ggRB7zrz1TbxToZTYSDoBO9Cmp6yuHadSXaxf2_Uwjw3L5w8Jyc8QeiKkimlBb0ldPq2fJ2SVFRJWarUJiWbNuwIjWnORCYKJo_RmBCuMiaUGqGzED4Tz7jMT9GIFimJVGP0MTeda_d45ULs_R73DQ7R92vAdQ8Bb_qItx5qZyP2Lqz_nZsmgsfRm01wsInYBbuCzllsYjR2fY5OGtMGuBhygt7nD8vZU7Z4eXye3S8yK7iImZXG1IoTAZxSU8tSGipE1TBDKmZVzoxQsuK5koxzVRKac6UIFAKAKpCUT9DN371b33_tIETdpZdA25oN9Lugy2QmJwVP4N0faH0fgodGb73rjN9rSvSPV02oTl71wav-9aobloYvhy27qoP6MDqITMD1AJhgTdskLdaFA1cWpMjTf3wD4WSBTA</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>FLOSSMANN, Enrico</creator><creator>ROTHWELL, Peter M</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Family history of stroke does not predict risk of stroke after transient ischemic attack</title><author>FLOSSMANN, Enrico ; ROTHWELL, Peter M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-c8aad9304e311ad878a144bf2a0b2c952a498b3598233970153990e64ee19e813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain Ischemia - pathology</topic><topic>Cohort Studies</topic><topic>Disease-Free Survival</topic><topic>Family Health</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - complications</topic><topic>Ischemic Attack, Transient - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - genetics</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Stroke - diagnosis</topic><topic>Stroke - genetics</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FLOSSMANN, Enrico</creatorcontrib><creatorcontrib>ROTHWELL, Peter M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FLOSSMANN, Enrico</au><au>ROTHWELL, Peter M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family history of stroke does not predict risk of stroke after transient ischemic attack</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>37</volume><issue>2</issue><spage>544</spage><epage>546</epage><pages>544-546</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Animal models suggest a genetic contribution to cerebral susceptibility to ischemia. Family history of stroke (FHxstroke) is a risk factor for ischemic stroke, but there is significant confounding by heritability of hypertension and other intermediate phenotypes, and it is uncertain whether genetic factors have a direct independent influence on cerebral susceptibility to ischemia in man.
We related detailed FHxstroke to baseline characteristics and subsequent risk of stroke in 2 population-based incidence studies and a consecutive hospital-referred series of patients with recent transient ischemic attack (TIA).
In none of the cohorts or the pooled data (757 patients; 5515 patient years follow-up; 200 ischemic strokes; 126 myocardial infarctions [MIs]) did FHxstroke predict ischemic stroke (odds ratio [OR], 0.87; 95% CI, 0.57 to 1.32). No associations were revealed by analyses stratified by age or hypertension in the proband, FHx(stroke) in parents versus siblings, number of affected relatives, or their age at stroke. FHxstroke was unrelated to presence of ischemic lesions on baseline computed tomography (OR, 0.96; 0.52 to 1.76) or risk of MI during follow-up. There was no bias attributable to any relationship between FHxstroke and risk factor control or medication.
Family history of stroke does not predict risk of ischemic stroke after TIA.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16385089</pmid><doi>10.1161/01.STR.0000198879.11072.f2</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2006-02, Vol.37 (2), p.544-546 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70725063 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain Ischemia - pathology Cohort Studies Disease-Free Survival Family Health Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Ischemic Attack, Transient - complications Ischemic Attack, Transient - genetics Male Medical sciences Middle Aged Myocardial Infarction - diagnosis Myocardial Infarction - genetics Nervous system (semeiology, syndromes) Neurology Odds Ratio Pharmacology. Drug treatments Phenotype Prognosis Risk Risk Factors Stroke - diagnosis Stroke - genetics Time Factors Tomography, X-Ray Computed Vascular diseases and vascular malformations of the nervous system |
| title | Family history of stroke does not predict risk of stroke after transient ischemic attack |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T21%3A35%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Family%20history%20of%20stroke%20does%20not%20predict%20risk%20of%20stroke%20after%20transient%20ischemic%20attack&rft.jtitle=Stroke%20(1970)&rft.au=FLOSSMANN,%20Enrico&rft.date=2006-02-01&rft.volume=37&rft.issue=2&rft.spage=544&rft.epage=546&rft.pages=544-546&rft.issn=0039-2499&rft.eissn=1524-4628&rft.coden=SJCCA7&rft_id=info:doi/10.1161/01.STR.0000198879.11072.f2&rft_dat=%3Cproquest_cross%3E70725063%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70725063&rft_id=info:pmid/16385089&rfr_iscdi=true |