Use of microbore LC–MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples

A microbore LC–MS/MS method is developed and validated for the quantification of the anti-epileptic drug oxcarbazepine (OXC) and its active metabolite 10,11-dihydro-10-hydroxycarbamazepine (MHD) in rat brain microdialysates, together with the internal standard for microdialysis probe calibration, 2-...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2006-02, Vol.831 (1), p.205-212
Hauptverfasser:	Lanckmans, Katrien, Clinckers, Ralph, Van Eeckhaut, Ann, Sarre, Sophie, Smolders, Ilse, Michotte, Yvette
Format:	Artikel
Sprache:	eng
Schlagworte:	10,11-Dihydro-10-hydroxycarbamazepine Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Brain Chemistry Carbamazepine - analogs & derivatives Carbamazepine - analysis Carbamazepine - metabolism Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Column switching Fundamental and applied biological sciences. Psychology General pharmacology Hippocampus - chemistry Male Mass Spectrometry Medical sciences Microbore LC–MS/MS Microdialysis Oxcarbazepine Pharmacology. Drug treatments Rat brain microdialysis Rats Rats, Wistar Reproducibility of Results
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