Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity

Our previous studies suggest that replication-defective Sindbis vectors might be promising agents for specific tumor targeting and detection. However, the effects of innate and/or adaptive anti-viral immunity, in particular, the IFN-I/STAT1 signaling pathway, may impact their therapeutic potential....

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Veröffentlicht in:	Gene therapy 2007-08, Vol.14 (15), p.1166-1174
Hauptverfasser:	Tseng, J-C, Zheng, Y, Yee, H, Levy, D E, Meruelo, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Alphavirus Infections - immunology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antiviral agents Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cell Biology Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic vectors Genetic Vectors - administration & dosage Genetic Vectors - immunology Health aspects Health. Pharmaceutical industry Hepatocytes Human Genetics Immune system Immunity Immunity, Innate Industrial applications and implications. Economical aspects Interferon regulatory factor 7 Interferon Type I - genetics Interferon Type I - immunology Liver Liver - immunology Liver - virology Luminescence Medical sciences Mice Mice, Knockout Nanotechnology Natural immunity Neoplasms - immunology Neoplasms - therapy NF-kappa B - genetics NF-κB protein Receptors, Tumor Necrosis Factor, Type I - genetics Replication Rodents short-communication Signal transduction Sindbis Virus - genetics Stat1 protein STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism TLR3 protein Toll-Like Receptor 3 - genetics Toll-like receptors Transcription activation Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tropism Tumor cells Tumors USP18 protein α-Interferon
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