Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study
Introduction: The harmful effects of ischaemia-reperfusion on skeletal muscle during extremity surgery can be diminished by using medications or ischaemic preconditioning Methods: Twenty patients undergoing lower-limb surgery with use of a tourniquet for at least 1 hour were included in the study an...
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| Veröffentlicht in: | Advances in therapy 2008-04, Vol.25 (4), p.355-366 |
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| creator | Van, Mukaddes Olguner, Çimen Koca, Uğur Şişman, Ali Riza Muratli, Kivanç Karci, Ayşe Mavioğlu, Ömür Kilercik, Hakan |
| description | Introduction:
The harmful effects of ischaemia-reperfusion on skeletal muscle during extremity surgery can be diminished by using medications or ischaemic preconditioning
Methods:
Twenty patients undergoing lower-limb surgery with use of a tourniquet for at least 1 hour were included in the study and randomised into two groups: a control group with only tourniquet application (T group;
n
=10); and an ischaemic preconditioning plus tourniquet group (IP-T group;
n
=10). Blood samples were obtained from the femoral vein of the relevant extremity before tourniquet application (baseline), immediately after tourniquet deflation (TD), at 10 minutes after the tourniquet deflation (TD
10min
) in the T group and additionally after ischaemic preconditioning in the IP-T group. Venous blood pH, partial oxygen pressure (P
vO2
), partial carbon dioxide pressure (P
vCO2
), lactate, potassium, sodium and glucose levels were analysed using a blood gas analyser. Plasma thiobarbituric acid reactive substances (TBARS) level, an index of lipid peroxidation and oxidative stress, was measured. Heart rate, noninvasive mean arterial pressure (MAP) and spontaneous breathing rate (SBR) were recorded at baseline, at TD, and TD
1min
, TD
5min
and TD
10min
Results:
MAP decreased and SBR increased significantly at TD, TD
1min
and TD
5min
compared with baseline, and venous blood TBARS level significantly increased at TD and TD
10min
compared with baseline in the T group (all
P |
| doi_str_mv | 10.1007/s12325-008-0037-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70721207</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70721207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-3bb6c735cb366fe48d3848b729a4c3ae020398fb28a3e107c33247488141db543</originalsourceid><addsrcrecordid>eNp9kU1rFTEYhYMo9lr9AW4kK3ej-Zqb1F0pVQsFNwruQiZ5b5uSScZ80M4P8_-Z8V5w5-IlhDzn8OYchN5S8oESIj8WyjgbB0JUHy4H-QztqNqPQx_2HO2IFHRgXP08Q69KeSCEETmql-iMKi45U3SHft8Ue29g9hYvGWyKzlefoo932NQKsZkKBW9Ecms0G5ehLCkWwCY6HPziHV4gpyfvzCbFPuKQHiEP8FRzd64rLi3fQV7xo6_3uEUfums2AS8R2txVFtfUcvS_GlRsliV4-9frE77ENvjYrx32IVVcanPra_TiYEKBN6fzHP34fP396utw--3LzdXl7WC5YHXg07S3ko924vv9AYRyXAk1SXZhhOUGeh78Qh0mpgwHSqTlnAkplKKCumkU_By9P_ouOfXdStWzLxZCMBFSK1oSyWgPtYP0CNqcSslw0Ev2s8mrpkRvXeljV7p3pbeu9KZ5dzJv0wzun-JUTgfYESj9KfYA9cOWUv_wf1z_AE46pUM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70721207</pqid></control><display><type>article</type><title>Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study</title><source>MEDLINE</source><source>Springer Online Journals</source><creator>Van, Mukaddes ; Olguner, Çimen ; Koca, Uğur ; Şişman, Ali Riza ; Muratli, Kivanç ; Karci, Ayşe ; Mavioğlu, Ömür ; Kilercik, Hakan</creator><creatorcontrib>Van, Mukaddes ; Olguner, Çimen ; Koca, Uğur ; Şişman, Ali Riza ; Muratli, Kivanç ; Karci, Ayşe ; Mavioğlu, Ömür ; Kilercik, Hakan</creatorcontrib><description>Introduction:
The harmful effects of ischaemia-reperfusion on skeletal muscle during extremity surgery can be diminished by using medications or ischaemic preconditioning
Methods:
Twenty patients undergoing lower-limb surgery with use of a tourniquet for at least 1 hour were included in the study and randomised into two groups: a control group with only tourniquet application (T group;
n
=10); and an ischaemic preconditioning plus tourniquet group (IP-T group;
n
=10). Blood samples were obtained from the femoral vein of the relevant extremity before tourniquet application (baseline), immediately after tourniquet deflation (TD), at 10 minutes after the tourniquet deflation (TD
10min
) in the T group and additionally after ischaemic preconditioning in the IP-T group. Venous blood pH, partial oxygen pressure (P
vO2
), partial carbon dioxide pressure (P
vCO2
), lactate, potassium, sodium and glucose levels were analysed using a blood gas analyser. Plasma thiobarbituric acid reactive substances (TBARS) level, an index of lipid peroxidation and oxidative stress, was measured. Heart rate, noninvasive mean arterial pressure (MAP) and spontaneous breathing rate (SBR) were recorded at baseline, at TD, and TD
1min
, TD
5min
and TD
10min
Results:
MAP decreased and SBR increased significantly at TD, TD
1min
and TD
5min
compared with baseline, and venous blood TBARS level significantly increased at TD and TD
10min
compared with baseline in the T group (all
P
<0.05). No significant changes were observed in the IP-T group. Ischaemic preconditioning caused a rise in P
vO2
and a decrease in venous blood pH, P
vCO2
, and lactate levels, which was significant compared with baseline (
P
<0.05)
Conclusion:
Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation during lower-extremity surgery with unilateral tourniquet application</description><identifier>ISSN: 0741-238X</identifier><identifier>EISSN: 1865-8652</identifier><identifier>DOI: 10.1007/s12325-008-0037-7</identifier><identifier>PMID: 18373281</identifier><language>eng</language><publisher>Heidelberg: Springer Healthcare Communications</publisher><subject>Adult ; Blood Gas Analysis ; Blood Pressure ; Cardiology ; Endocrinology ; Femoral Vein ; Health technology assessment ; Hemodynamics ; Humans ; Internal Medicine ; Ischemic Preconditioning - methods ; Lipid Peroxidation ; Lower Extremity - blood supply ; Lower Extremity - surgery ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Pharmacology/Toxicology ; Pilot Projects ; Prospective Studies ; Reperfusion Injury - prevention & control ; Rheumatology ; Single-Blind Method ; Thiobarbituric Acid Reactive Substances - metabolism ; Tourniquets</subject><ispartof>Advances in therapy, 2008-04, Vol.25 (4), p.355-366</ispartof><rights>Springer Healthcare Communications 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-3bb6c735cb366fe48d3848b729a4c3ae020398fb28a3e107c33247488141db543</citedby><cites>FETCH-LOGICAL-c342t-3bb6c735cb366fe48d3848b729a4c3ae020398fb28a3e107c33247488141db543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12325-008-0037-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12325-008-0037-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18373281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van, Mukaddes</creatorcontrib><creatorcontrib>Olguner, Çimen</creatorcontrib><creatorcontrib>Koca, Uğur</creatorcontrib><creatorcontrib>Şişman, Ali Riza</creatorcontrib><creatorcontrib>Muratli, Kivanç</creatorcontrib><creatorcontrib>Karci, Ayşe</creatorcontrib><creatorcontrib>Mavioğlu, Ömür</creatorcontrib><creatorcontrib>Kilercik, Hakan</creatorcontrib><title>Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study</title><title>Advances in therapy</title><addtitle>Adv Therapy</addtitle><addtitle>Adv Ther</addtitle><description>Introduction:
The harmful effects of ischaemia-reperfusion on skeletal muscle during extremity surgery can be diminished by using medications or ischaemic preconditioning
Methods:
Twenty patients undergoing lower-limb surgery with use of a tourniquet for at least 1 hour were included in the study and randomised into two groups: a control group with only tourniquet application (T group;
n
=10); and an ischaemic preconditioning plus tourniquet group (IP-T group;
n
=10). Blood samples were obtained from the femoral vein of the relevant extremity before tourniquet application (baseline), immediately after tourniquet deflation (TD), at 10 minutes after the tourniquet deflation (TD
10min
) in the T group and additionally after ischaemic preconditioning in the IP-T group. Venous blood pH, partial oxygen pressure (P
vO2
), partial carbon dioxide pressure (P
vCO2
), lactate, potassium, sodium and glucose levels were analysed using a blood gas analyser. Plasma thiobarbituric acid reactive substances (TBARS) level, an index of lipid peroxidation and oxidative stress, was measured. Heart rate, noninvasive mean arterial pressure (MAP) and spontaneous breathing rate (SBR) were recorded at baseline, at TD, and TD
1min
, TD
5min
and TD
10min
Results:
MAP decreased and SBR increased significantly at TD, TD
1min
and TD
5min
compared with baseline, and venous blood TBARS level significantly increased at TD and TD
10min
compared with baseline in the T group (all
P
<0.05). No significant changes were observed in the IP-T group. Ischaemic preconditioning caused a rise in P
vO2
and a decrease in venous blood pH, P
vCO2
, and lactate levels, which was significant compared with baseline (
P
<0.05)
Conclusion:
Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation during lower-extremity surgery with unilateral tourniquet application</description><subject>Adult</subject><subject>Blood Gas Analysis</subject><subject>Blood Pressure</subject><subject>Cardiology</subject><subject>Endocrinology</subject><subject>Femoral Vein</subject><subject>Health technology assessment</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Ischemic Preconditioning - methods</subject><subject>Lipid Peroxidation</subject><subject>Lower Extremity - blood supply</subject><subject>Lower Extremity - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Rheumatology</subject><subject>Single-Blind Method</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tourniquets</subject><issn>0741-238X</issn><issn>1865-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rFTEYhYMo9lr9AW4kK3ej-Zqb1F0pVQsFNwruQiZ5b5uSScZ80M4P8_-Z8V5w5-IlhDzn8OYchN5S8oESIj8WyjgbB0JUHy4H-QztqNqPQx_2HO2IFHRgXP08Q69KeSCEETmql-iMKi45U3SHft8Ue29g9hYvGWyKzlefoo932NQKsZkKBW9Ecms0G5ehLCkWwCY6HPziHV4gpyfvzCbFPuKQHiEP8FRzd64rLi3fQV7xo6_3uEUfums2AS8R2txVFtfUcvS_GlRsliV4-9frE77ENvjYrx32IVVcanPra_TiYEKBN6fzHP34fP396utw--3LzdXl7WC5YHXg07S3ko924vv9AYRyXAk1SXZhhOUGeh78Qh0mpgwHSqTlnAkplKKCumkU_By9P_ouOfXdStWzLxZCMBFSK1oSyWgPtYP0CNqcSslw0Ev2s8mrpkRvXeljV7p3pbeu9KZ5dzJv0wzun-JUTgfYESj9KfYA9cOWUv_wf1z_AE46pUM</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Van, Mukaddes</creator><creator>Olguner, Çimen</creator><creator>Koca, Uğur</creator><creator>Şişman, Ali Riza</creator><creator>Muratli, Kivanç</creator><creator>Karci, Ayşe</creator><creator>Mavioğlu, Ömür</creator><creator>Kilercik, Hakan</creator><general>Springer Healthcare Communications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study</title><author>Van, Mukaddes ; Olguner, Çimen ; Koca, Uğur ; Şişman, Ali Riza ; Muratli, Kivanç ; Karci, Ayşe ; Mavioğlu, Ömür ; Kilercik, Hakan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-3bb6c735cb366fe48d3848b729a4c3ae020398fb28a3e107c33247488141db543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Blood Gas Analysis</topic><topic>Blood Pressure</topic><topic>Cardiology</topic><topic>Endocrinology</topic><topic>Femoral Vein</topic><topic>Health technology assessment</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Ischemic Preconditioning - methods</topic><topic>Lipid Peroxidation</topic><topic>Lower Extremity - blood supply</topic><topic>Lower Extremity - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Rheumatology</topic><topic>Single-Blind Method</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tourniquets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van, Mukaddes</creatorcontrib><creatorcontrib>Olguner, Çimen</creatorcontrib><creatorcontrib>Koca, Uğur</creatorcontrib><creatorcontrib>Şişman, Ali Riza</creatorcontrib><creatorcontrib>Muratli, Kivanç</creatorcontrib><creatorcontrib>Karci, Ayşe</creatorcontrib><creatorcontrib>Mavioğlu, Ömür</creatorcontrib><creatorcontrib>Kilercik, Hakan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van, Mukaddes</au><au>Olguner, Çimen</au><au>Koca, Uğur</au><au>Şişman, Ali Riza</au><au>Muratli, Kivanç</au><au>Karci, Ayşe</au><au>Mavioğlu, Ömür</au><au>Kilercik, Hakan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study</atitle><jtitle>Advances in therapy</jtitle><stitle>Adv Therapy</stitle><addtitle>Adv Ther</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>25</volume><issue>4</issue><spage>355</spage><epage>366</epage><pages>355-366</pages><issn>0741-238X</issn><eissn>1865-8652</eissn><abstract>Introduction:
The harmful effects of ischaemia-reperfusion on skeletal muscle during extremity surgery can be diminished by using medications or ischaemic preconditioning
Methods:
Twenty patients undergoing lower-limb surgery with use of a tourniquet for at least 1 hour were included in the study and randomised into two groups: a control group with only tourniquet application (T group;
n
=10); and an ischaemic preconditioning plus tourniquet group (IP-T group;
n
=10). Blood samples were obtained from the femoral vein of the relevant extremity before tourniquet application (baseline), immediately after tourniquet deflation (TD), at 10 minutes after the tourniquet deflation (TD
10min
) in the T group and additionally after ischaemic preconditioning in the IP-T group. Venous blood pH, partial oxygen pressure (P
vO2
), partial carbon dioxide pressure (P
vCO2
), lactate, potassium, sodium and glucose levels were analysed using a blood gas analyser. Plasma thiobarbituric acid reactive substances (TBARS) level, an index of lipid peroxidation and oxidative stress, was measured. Heart rate, noninvasive mean arterial pressure (MAP) and spontaneous breathing rate (SBR) were recorded at baseline, at TD, and TD
1min
, TD
5min
and TD
10min
Results:
MAP decreased and SBR increased significantly at TD, TD
1min
and TD
5min
compared with baseline, and venous blood TBARS level significantly increased at TD and TD
10min
compared with baseline in the T group (all
P
<0.05). No significant changes were observed in the IP-T group. Ischaemic preconditioning caused a rise in P
vO2
and a decrease in venous blood pH, P
vCO2
, and lactate levels, which was significant compared with baseline (
P
<0.05)
Conclusion:
Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation during lower-extremity surgery with unilateral tourniquet application</abstract><cop>Heidelberg</cop><pub>Springer Healthcare Communications</pub><pmid>18373281</pmid><doi>10.1007/s12325-008-0037-7</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0741-238X |
| ispartof | Advances in therapy, 2008-04, Vol.25 (4), p.355-366 |
| issn | 0741-238X 1865-8652 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70721207 |
| source | MEDLINE; Springer Online Journals |
| subjects | Adult Blood Gas Analysis Blood Pressure Cardiology Endocrinology Femoral Vein Health technology assessment Hemodynamics Humans Internal Medicine Ischemic Preconditioning - methods Lipid Peroxidation Lower Extremity - blood supply Lower Extremity - surgery Medicine Medicine & Public Health Oncology Original Research Pharmacology/Toxicology Pilot Projects Prospective Studies Reperfusion Injury - prevention & control Rheumatology Single-Blind Method Thiobarbituric Acid Reactive Substances - metabolism Tourniquets |
| title | Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study |
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