Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic

Cervical cancer is the second most prevalent cancer in women worldwide. It is linked to infection with human papillomavirus (HPV). As the virus cannot be propagated in culture, vaccines based on virus-like particles have been developed and recently marketed. However, their high costs constitute an i...

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Veröffentlicht in:	Plant biotechnology journal 2008-06, Vol.6 (5), p.427-441
Hauptverfasser:	Fernández-San Millán, Alicia, Ortigosa, Susana M, Hervás-Stubbs, Sandra, Corral-Martínez, Patricia, Seguí-Simarro, José M, Gaétan, Julien, Coursaget, Pierre, Veramendi, Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Biological and medical sciences Biotechnology Capsid Proteins - biosynthesis Capsid Proteins - chemistry Capsid Proteins - immunology Chloroplasts - metabolism Chloroplasts - ultrastructure Fundamental and applied biological sciences. Psychology Genetic Vectors Genome, Plant Health. Pharmaceutical industry human papillomavirus Humans Immunoblotting Immunohistochemistry Industrial applications and implications. Economical aspects Mice Microscopy, Electron Nicotiana - genetics Nicotiana - metabolism Nicotiana - ultrastructure Oncogene Proteins, Viral - biosynthesis Oncogene Proteins, Viral - chemistry Oncogene Proteins, Viral - immunology Papillomaviridae plant vaccine Plants, Genetically Modified plastid transformation Production of active biomolecules Protein Structure, Quaternary tobacco Transformation, Genetic Vaccins Virion - immunology Virion - isolation & purification Virion - ultrastructure virus-like particles
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