Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways

Wnts are secreted glycoproteins that control diverse biological processes, such as proliferation, differentiation, and apoptosis. We here found that Wnt5a inhibited apoptosis induced by serum deprivation in primary-cultured human dermal fibroblasts. Anti-apoptotic activity of Wnt5a was not inhibited...

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Veröffentlicht in:	Cellular signalling 2008-07, Vol.20 (7), p.1256-1266
Hauptverfasser:	Torii, Kosuke, Nishizawa, Koji, Kawasaki, Aya, Yamashita, Yuki, Katada, Masanori, Ito, Minoru, Nishimoto, Ikuo, Terashita, Kenzo, Aiso, Sadakazu, Matsuoka, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects beta Catenin - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Dermis - cytology Dermis - enzymology Enzyme Activation - drug effects Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - enzymology Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans LDL-Receptor Related Proteins - metabolism Low Density Lipoprotein Receptor-Related Protein-5 Low Density Lipoprotein Receptor-Related Protein-6 Models, Biological Phosphorylation - drug effects Phosphoserine - metabolism PKA Receptors, LDL - metabolism Signal Transduction - drug effects Wnt Proteins - pharmacology Wnt5a β-catenin
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