Cellular and molecular effects of protons: apoptosis induction and potential implications for cancer therapy

Due to their ballistic precision, apoptosis induction by protons could be a strategy to specifically eliminate neoplastic cells. To characterize the cellular and molecular effects of these hadrons, we performed dose-response and time-course experiments by exposing different cell lines (PC3, Ca301D,...

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Veröffentlicht in:	Apoptosis (London) 2006-01, Vol.11 (1), p.57-66
Hauptverfasser:	Di Pietro, C, Piro, S, Tabbì, G, Ragusa, M, Di Pietro, V, Zimmitti, V, Cuda, F, Anello, M, Consoli, U, Salinaro, E T, Caruso, M, Vancheri, C, Crimi, N, Sabini, M G, Cirrone, G A P, Raffaele, L, Privitera, G, Pulvirenti, A, Giugno, R, Ferro, A, Cuttone, G, Lo Nigro, S, Purrello, R, Purrello, F, Purrello, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Apoptosis - radiation effects Base Sequence Cancer therapies Cell Cycle - radiation effects Cell Line, Tumor DNA Damage DNA Primers - genetics Electron paramagnetic resonance Electron spin Electron spin resonance Electron Spin Resonance Spectroscopy Female Flow Cytometry Hadrons Humans Hydroxyl ions Intracellular levels Irradiation Male Mitochondria Necrosis Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - radiotherapy Photons Photons - therapeutic use Polymerase chain reaction Proton beams Proton irradiation Protons Protons - therapeutic use Radiation dosage Reactive oxygen species Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Neoplasm - genetics Spin resonance Transcriptomes
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