Downregulation of the Hemoglobin Scavenger Receptor in Individuals With Diabetes and the Hp 2-2 Genotype: Implications for the Response to Intraplaque Hemorrhage and Plaque Vulnerability

In individuals with diabetes mellitus (DM), the haptoglobin (Hp) genotype is a major determinant of susceptibility to myocardial infarction. We have proposed that this is because of DM and Hp genotype-dependent differences in the response to intraplaque hemorrhage. The macrophage hemoglobin scavengi...

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Veröffentlicht in:	Circulation research 2007-07, Vol.101 (1), p.106-110
Hauptverfasser:	Levy, Andrew P, Purushothaman, K Raman, Levy, Nina S, Purushothaman, Meerarani, Strauss, Merav, Asleh, Rabea, Marsh, Stuart, Cohen, Osher, Moestrup, Soren K, Moller, Holger J, Zias, Elias A, Benhayon, Daniel, Fuster, Valentin, Moreno, Pedro R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - blood Antigens, CD - genetics Antigens, Differentiation, Myelomonocytic - biosynthesis Antigens, Differentiation, Myelomonocytic - blood Antigens, Differentiation, Myelomonocytic - genetics Diabetes Mellitus - blood Diabetes Mellitus - genetics Diabetes Mellitus - pathology Down-Regulation - genetics Genetic Predisposition to Disease - epidemiology Genotype Haptoglobins - genetics Haptoglobins - metabolism Hemoglobins - genetics Hemoglobins - metabolism Hemorrhage - blood Hemorrhage - epidemiology Hemorrhage - genetics Humans Incidence Macrophages - metabolism Myocardial Infarction - blood Myocardial Infarction - epidemiology Myocardial Infarction - genetics Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - blood Receptors, Cell Surface - genetics Receptors, Scavenger - antagonists & inhibitors Receptors, Scavenger - blood Receptors, Scavenger - genetics
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