Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria

Polyphosphate kinase 1 (PPK1) helps bacteria to survive under stress. The ppk1 gene of Mycobacterium tuberculosis was overexpressed in Escherichia coli and characterized. Residues R230 and F176, predicted to be present in the head domain of PPK1, were identified as residues critical for polyphosphat...

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Veröffentlicht in:	Molecular microbiology 2007-07, Vol.65 (2), p.261-276
Hauptverfasser:	Sureka, Kamakshi, Dey, Supratim, Datta, Pratik, Singh, Anil Kumar, Dasgupta, Arunava, Rodrigue, Sébastien, Basu, Joyoti, Kundu, Manikuntala
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobiosis - genetics Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Down-Regulation Escherichia coli - genetics Gene Expression Regulation, Bacterial Genes Kinases Ligases - genetics Ligases - metabolism Mycobacterium smegmatis - enzymology Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Oxidative Stress Phosphates Phosphotransferases (Phosphate Group Acceptor) - genetics Phosphotransferases (Phosphate Group Acceptor) - metabolism Point Mutation Polyphosphates - metabolism Sigma Factor - genetics Sigma Factor - metabolism Signal Transduction Transcription, Genetic
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