Novel Synthesis of the Ortho Ester Derivative of 4,5-Epoxymorphinan

A method was found for the novel synthesis of ortho ester derivatives that are potentially useful as selective ε opioid receptor ligands. An unexpected 17-(cyclopropylmethyl)-4,5α-epoxy-6α-hydroxy-3,7,7-trimethoxy-8-oxa-6,14-endoethanomorphinan was produced when 17-(cyclopropylmethyl)-4,5α-epoxy-3-m...

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Veröffentlicht in:	Organic letters 2006-02, Vol.8 (3), p.523-526
Hauptverfasser:	Watanabe, Akio, Kai, Toshitsugu, Nagase, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Esters Magnetic Resonance Spectroscopy Molecular Structure Morphinans - chemical synthesis Morphinans - chemistry Stereoisomerism
Online-Zugang:	Volltext
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