Rapid quantification of gabapentin in human plasma by liquid chromatography/tandem mass spectrometry

A simple, sensitive and rapid liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the quantification of gabapentin, a new antiepileptic drug, in human plasma using its structural analogue, 1,1-cyclohexane diacetic acid monoamide (CAM) as internal standard...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2006-02, Vol.40 (2), p.360-368
Hauptverfasser:	Ramakrishna, N.V.S., Vishwottam, K.N., Koteshwara, M., Manoj, S., Santosh, M., Chidambara, J., Sumatha, B., Varma, D.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,1-Cyclohexane diacetic acid monoamide (CAM) Amines - administration & dosage Amines - blood Analysis Analytical, structural and metabolic biochemistry Anticonvulsants - blood Biological and medical sciences Chromatography, Liquid - methods Cyclohexanecarboxylic Acids - administration & dosage Cyclohexanecarboxylic Acids - blood Drug Stability Fundamental and applied biological sciences. Psychology Gabapentin gamma-Aminobutyric Acid - administration & dosage gamma-Aminobutyric Acid - blood General pharmacology Human plasma Humans Liquid chromatography/tandem mass spectrometry Medical sciences Pharmacokinetic study Pharmacology. Drug treatments Reproducibility of Results Spectrometry, Mass, Electrospray Ionization Temperature Time Factors
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