A photoaffinity, non-steroidal, ecdysone agonist, bisacylhydrazine compound, RH-131039: Characterization of binding and functional activity

In this paper we describe the synthesis, ligand-binding and functional activity characteristics of the photoaffinity, non-steroidal, ecdysone agonist, bisacylhydrazine compound, 3-benzoyl-benzoic acid N-tert-butyl- N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (RH-131039). Tritiated RH-131039 is the firs...

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Veröffentlicht in:	Insect biochemistry and molecular biology 2007-08, Vol.37 (8), p.865-875
Hauptverfasser:	Dhadialla, Tarlochan S., Le, Dat, Palli, Subha R., Raikhel, Alexander, Carlson, Glenn R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes aegypti Animals Arthropoda Benzamides - chemical synthesis Benzamides - chemistry Benzamides - metabolism binding capacity binding properties Binding Sites Cell Extracts Cells, Cultured Chironomus tentans Choristoneura fumiferana Diptera Dipteran EcR Drosophila - cytology Drosophila melanogaster ecdysone agonists Ecdysteroid receptor ecdysteroid receptors ecdysteroids Ecdysterone - analogs & derivatives Ecdysterone - metabolism hormone receptors hydrazides Hydrazines - chemical synthesis Hydrazines - chemistry Hydrazines - metabolism Insect Proteins - metabolism labeling techniques Lepidoptera Lepidopteran EcR ligand-binding Ligands Limited proteolysis Moths - metabolism Non-steroidal ecdysone agonist Photoaffinity ecdysone agonist Photoaffinity labeling Photoaffinity Labels - chemical synthesis Photoaffinity Labels - chemistry Photoaffinity Labels - metabolism Receptors, Steroid - metabolism synthesis ultraviolet radiation
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