Tracking the urinary excretion of high molar mass poly(vinyl alcohol)
The fate of poly(vinyl alcohol) (PVA) of weight average molar mass of 125,000 g/mol after administration into the peritoneum of rabbits has bean studied by various methods. PVA was spin‐labeled with a nitroxide radical and then detected in urine using electron spin resonance (ESR) spectroscopy. Furt...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2007-08, Vol.82B (2), p.383-389 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 389 |
|---|---|
| container_issue | 2 |
| container_start_page | 383 |
| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
| container_volume | 82B |
| creator | Besheer, Ahmed Mäder, Karsten Kaiser, Sergej Kressler, Jörg Weis, Christine Odermatt, Erich K. |
| description | The fate of poly(vinyl alcohol) (PVA) of weight average molar mass of 125,000 g/mol after administration into the peritoneum of rabbits has bean studied by various methods. PVA was spin‐labeled with a nitroxide radical and then detected in urine using electron spin resonance (ESR) spectroscopy. Furthermore, unlabeled polymer was also administered to rabbits, then the urine was collected, dialyzed, precipitated, and the excretion of PVA was confirmed by size exclusion chromatography (SEC), FTIR spectroscopy, and 1H NMR spectroscopy. ESR and SEC results show that, despite its relatively high molar mass, PVA is excreted through the kidneys without significant molar mass changes. Nevertheless, NMR and FTIR spectra show slight differences between the excreted and neat PVA. Possible causes of these discrepancies are discussed. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007 |
| doi_str_mv | 10.1002/jbm.b.30743 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70715975</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20518786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4293-2b922ceb42c41e3719a7bd42f621bb087e82c6e53a5c45bb4f73285cb47d2b563</originalsourceid><addsrcrecordid>eNqFkTlPAzEQRi0E4q7okSsEQht8rndLCLdCkBBHadmOlxi862AnQP49CwnQQTVTvO-NNB8AWxh1MELk4EnXHd2hSDC6AFYx5yRjZYEXf3ZBV8BaSk8tnCNOl8EKFoQWOM9XwcltVObZNY9wPLRwEl2j4hTadxPt2IUGhgoO3eMQ1sGrCGuVEhwFP919dc3UQ-VNGAa_twGWKuWT3ZzPdXB3enLbPc9612cX3cNeZhgpaUZ0SYixmhHDsKUCl0roASNVTrDWqBC2ICa3nCpuGNeaVYKSghvNxIBontN1sDPzjmJ4mdg0lrVLxnqvGhsmSQokMC8F_xekCLGcYfYvSBDHhSg-T-_PQBNDStFWchRd3T5LYiQ_e5BtD1LLrx5aenuunejaDn7Z-eNbAM-AN-ft9C-XvDy6-pZms4xLY_v-k1HxWeaCCi4f-mfy5rh_T3pYyD79AGHLoO4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20518786</pqid></control><display><type>article</type><title>Tracking the urinary excretion of high molar mass poly(vinyl alcohol)</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Besheer, Ahmed ; Mäder, Karsten ; Kaiser, Sergej ; Kressler, Jörg ; Weis, Christine ; Odermatt, Erich K.</creator><creatorcontrib>Besheer, Ahmed ; Mäder, Karsten ; Kaiser, Sergej ; Kressler, Jörg ; Weis, Christine ; Odermatt, Erich K.</creatorcontrib><description>The fate of poly(vinyl alcohol) (PVA) of weight average molar mass of 125,000 g/mol after administration into the peritoneum of rabbits has bean studied by various methods. PVA was spin‐labeled with a nitroxide radical and then detected in urine using electron spin resonance (ESR) spectroscopy. Furthermore, unlabeled polymer was also administered to rabbits, then the urine was collected, dialyzed, precipitated, and the excretion of PVA was confirmed by size exclusion chromatography (SEC), FTIR spectroscopy, and 1H NMR spectroscopy. ESR and SEC results show that, despite its relatively high molar mass, PVA is excreted through the kidneys without significant molar mass changes. Nevertheless, NMR and FTIR spectra show slight differences between the excreted and neat PVA. Possible causes of these discrepancies are discussed. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.30743</identifier><identifier>PMID: 17238166</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>adhesion prevention ; Animals ; Chromatography, Gel ; Electron Spin Resonance Spectroscopy ; ESR spectroscopy ; Kidney - physiology ; Magnetic Resonance Spectroscopy ; Molecular Weight ; poly(vinyl alcohol) ; Polyvinyl Alcohol - administration & dosage ; Polyvinyl Alcohol - analysis ; Rabbits ; Spectroscopy, Fourier Transform Infrared ; spin label ; Urinalysis ; urinary excretion ; Urine - chemistry</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2007-08, Vol.82B (2), p.383-389</ispartof><rights>Copyright © 2007 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4293-2b922ceb42c41e3719a7bd42f621bb087e82c6e53a5c45bb4f73285cb47d2b563</citedby><cites>FETCH-LOGICAL-c4293-2b922ceb42c41e3719a7bd42f621bb087e82c6e53a5c45bb4f73285cb47d2b563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.30743$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.30743$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17238166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Besheer, Ahmed</creatorcontrib><creatorcontrib>Mäder, Karsten</creatorcontrib><creatorcontrib>Kaiser, Sergej</creatorcontrib><creatorcontrib>Kressler, Jörg</creatorcontrib><creatorcontrib>Weis, Christine</creatorcontrib><creatorcontrib>Odermatt, Erich K.</creatorcontrib><title>Tracking the urinary excretion of high molar mass poly(vinyl alcohol)</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J. Biomed. Mater. Res</addtitle><description>The fate of poly(vinyl alcohol) (PVA) of weight average molar mass of 125,000 g/mol after administration into the peritoneum of rabbits has bean studied by various methods. PVA was spin‐labeled with a nitroxide radical and then detected in urine using electron spin resonance (ESR) spectroscopy. Furthermore, unlabeled polymer was also administered to rabbits, then the urine was collected, dialyzed, precipitated, and the excretion of PVA was confirmed by size exclusion chromatography (SEC), FTIR spectroscopy, and 1H NMR spectroscopy. ESR and SEC results show that, despite its relatively high molar mass, PVA is excreted through the kidneys without significant molar mass changes. Nevertheless, NMR and FTIR spectra show slight differences between the excreted and neat PVA. Possible causes of these discrepancies are discussed. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007</description><subject>adhesion prevention</subject><subject>Animals</subject><subject>Chromatography, Gel</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>ESR spectroscopy</subject><subject>Kidney - physiology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Weight</subject><subject>poly(vinyl alcohol)</subject><subject>Polyvinyl Alcohol - administration & dosage</subject><subject>Polyvinyl Alcohol - analysis</subject><subject>Rabbits</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>spin label</subject><subject>Urinalysis</subject><subject>urinary excretion</subject><subject>Urine - chemistry</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTlPAzEQRi0E4q7okSsEQht8rndLCLdCkBBHadmOlxi862AnQP49CwnQQTVTvO-NNB8AWxh1MELk4EnXHd2hSDC6AFYx5yRjZYEXf3ZBV8BaSk8tnCNOl8EKFoQWOM9XwcltVObZNY9wPLRwEl2j4hTadxPt2IUGhgoO3eMQ1sGrCGuVEhwFP919dc3UQ-VNGAa_twGWKuWT3ZzPdXB3enLbPc9612cX3cNeZhgpaUZ0SYixmhHDsKUCl0roASNVTrDWqBC2ICa3nCpuGNeaVYKSghvNxIBontN1sDPzjmJ4mdg0lrVLxnqvGhsmSQokMC8F_xekCLGcYfYvSBDHhSg-T-_PQBNDStFWchRd3T5LYiQ_e5BtD1LLrx5aenuunejaDn7Z-eNbAM-AN-ft9C-XvDy6-pZms4xLY_v-k1HxWeaCCi4f-mfy5rh_T3pYyD79AGHLoO4</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Besheer, Ahmed</creator><creator>Mäder, Karsten</creator><creator>Kaiser, Sergej</creator><creator>Kressler, Jörg</creator><creator>Weis, Christine</creator><creator>Odermatt, Erich K.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Tracking the urinary excretion of high molar mass poly(vinyl alcohol)</title><author>Besheer, Ahmed ; Mäder, Karsten ; Kaiser, Sergej ; Kressler, Jörg ; Weis, Christine ; Odermatt, Erich K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4293-2b922ceb42c41e3719a7bd42f621bb087e82c6e53a5c45bb4f73285cb47d2b563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adhesion prevention</topic><topic>Animals</topic><topic>Chromatography, Gel</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>ESR spectroscopy</topic><topic>Kidney - physiology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Weight</topic><topic>poly(vinyl alcohol)</topic><topic>Polyvinyl Alcohol - administration & dosage</topic><topic>Polyvinyl Alcohol - analysis</topic><topic>Rabbits</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>spin label</topic><topic>Urinalysis</topic><topic>urinary excretion</topic><topic>Urine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Besheer, Ahmed</creatorcontrib><creatorcontrib>Mäder, Karsten</creatorcontrib><creatorcontrib>Kaiser, Sergej</creatorcontrib><creatorcontrib>Kressler, Jörg</creatorcontrib><creatorcontrib>Weis, Christine</creatorcontrib><creatorcontrib>Odermatt, Erich K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Besheer, Ahmed</au><au>Mäder, Karsten</au><au>Kaiser, Sergej</au><au>Kressler, Jörg</au><au>Weis, Christine</au><au>Odermatt, Erich K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tracking the urinary excretion of high molar mass poly(vinyl alcohol)</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2007-08</date><risdate>2007</risdate><volume>82B</volume><issue>2</issue><spage>383</spage><epage>389</epage><pages>383-389</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>The fate of poly(vinyl alcohol) (PVA) of weight average molar mass of 125,000 g/mol after administration into the peritoneum of rabbits has bean studied by various methods. PVA was spin‐labeled with a nitroxide radical and then detected in urine using electron spin resonance (ESR) spectroscopy. Furthermore, unlabeled polymer was also administered to rabbits, then the urine was collected, dialyzed, precipitated, and the excretion of PVA was confirmed by size exclusion chromatography (SEC), FTIR spectroscopy, and 1H NMR spectroscopy. ESR and SEC results show that, despite its relatively high molar mass, PVA is excreted through the kidneys without significant molar mass changes. Nevertheless, NMR and FTIR spectra show slight differences between the excreted and neat PVA. Possible causes of these discrepancies are discussed. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17238166</pmid><doi>10.1002/jbm.b.30743</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-4973 |
| ispartof | Journal of biomedical materials research. Part B, Applied biomaterials, 2007-08, Vol.82B (2), p.383-389 |
| issn | 1552-4973 1552-4981 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70715975 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adhesion prevention Animals Chromatography, Gel Electron Spin Resonance Spectroscopy ESR spectroscopy Kidney - physiology Magnetic Resonance Spectroscopy Molecular Weight poly(vinyl alcohol) Polyvinyl Alcohol - administration & dosage Polyvinyl Alcohol - analysis Rabbits Spectroscopy, Fourier Transform Infrared spin label Urinalysis urinary excretion Urine - chemistry |
| title | Tracking the urinary excretion of high molar mass poly(vinyl alcohol) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T14%3A31%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tracking%20the%20urinary%20excretion%20of%20high%20molar%20mass%20poly(vinyl%20alcohol)&rft.jtitle=Journal%20of%20biomedical%20materials%20research.%20Part%20B,%20Applied%20biomaterials&rft.au=Besheer,%20Ahmed&rft.date=2007-08&rft.volume=82B&rft.issue=2&rft.spage=383&rft.epage=389&rft.pages=383-389&rft.issn=1552-4973&rft.eissn=1552-4981&rft_id=info:doi/10.1002/jbm.b.30743&rft_dat=%3Cproquest_cross%3E20518786%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20518786&rft_id=info:pmid/17238166&rfr_iscdi=true |