Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin B1 expression in a p53-independent manner

A unique in vitro system has been developed in our lab that consists of normal enterocytes derived from the rat ileum (IEC-18 cells) and their transformed derivatives with c-K-ras (R1 cells), anti-sense bak (B3 cells) and cyclin D1 (D1 cells). R1 and B3 cells express high level of COX-2 protein and...

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Veröffentlicht in:	European journal of cancer (1990) 2006-02, Vol.42 (3), p.422-426
Hauptverfasser:	DVORY-SOBOL, Hadas, COHEN-NOYMAN, Efrat, KAZANOV, Diana, FIGER, Arie, BIRKENFELD, Shlomo, MADAR-SHAPIRO, Liora, BENAMOUZIG, Robert, ARBER, Nadir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Celecoxib Colorectal Neoplasms - drug therapy Cyclin B - drug effects Cyclin B - metabolism Cyclin-Dependent Kinase Inhibitor p21 - drug effects Cyclooxygenase 2 - drug effects Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dinoprostone - metabolism Down-Regulation - drug effects Enterocytes - drug effects Flow Cytometry G2 Phase - drug effects Genes, ras - drug effects Humans Medical sciences Pharmacology. Drug treatments Pyrazoles - pharmacology Rats Reverse Transcriptase Polymerase Chain Reaction Sulfonamides - pharmacology Tumor Suppressor Protein p53 - drug effects Tumors
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