Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice
The midbrain-localized Edinger-Westphal nucleus is a major site of production of urocortin 1. Urocortin 1 is a neuropeptide related to corticotropin-releasing factor that has high affinity for corticotropin-releasing factor type-1 and corticotropin-releasing factor type-2 receptors. In several mouse...
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| description | The midbrain-localized Edinger-Westphal nucleus is a major site of production of urocortin 1. Urocortin 1 is a neuropeptide related to corticotropin-releasing factor that has high affinity for corticotropin-releasing factor type-1 and corticotropin-releasing factor type-2 receptors. In several mouse models, the amount of urocortin 1 neurons within the Edinger-Westphal nucleus is positively associated with ethanol preference. Central administration of urocortin 1 exerts potent anorectic actions, and implicates endogenous urocortin 1 in the regulation of food intake. It is possible that brain areas such as the dorsal raphe, which receives urocortin 1 from the Edinger-Westphal nucleus and highly expresses corticotropin-releasing factor type-2 receptors, mediate the actions of urocortin 1 on feeding and ethanol preference. In this study the amount of food, water and ethanol consumed over the dark cycle by ethanol-preferring C57BL/6J mice was measured after injection of artificial cerebrospinal fluid vehicle, urocortin 1, corticotropin-releasing factor and the corticotropin-releasing factor type-2 receptor-selective antagonist antisauvagine-30 onto the dorsal raphe. Compared with vehicle, corticotropin-releasing factor and antisauvagine-30, urocortin 1 induced a significant reduction in the amount of food consumed overnight. Also, compared with antisauvagine-30 treatment, urocortin 1 significantly reduced the amount of weight gained during this time. Urocortin 1 also significantly reduced the total amount of fluid consumed, but did not alter ethanol preference, which was high during all treatments. These results suggest that the dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding, possibly through modulation of serotonergic activity from this nucleus. In addition, it is suggested that endogenous urocortin 1 in this area, such as from the Edinger-Westphal nucleus, does not regulate ethanol preference in C57BL/6J mice. |
| doi_str_mv | 10.1016/j.neuroscience.2005.10.021 |
| format | Article |
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Urocortin 1 is a neuropeptide related to corticotropin-releasing factor that has high affinity for corticotropin-releasing factor type-1 and corticotropin-releasing factor type-2 receptors. In several mouse models, the amount of urocortin 1 neurons within the Edinger-Westphal nucleus is positively associated with ethanol preference. Central administration of urocortin 1 exerts potent anorectic actions, and implicates endogenous urocortin 1 in the regulation of food intake. It is possible that brain areas such as the dorsal raphe, which receives urocortin 1 from the Edinger-Westphal nucleus and highly expresses corticotropin-releasing factor type-2 receptors, mediate the actions of urocortin 1 on feeding and ethanol preference. In this study the amount of food, water and ethanol consumed over the dark cycle by ethanol-preferring C57BL/6J mice was measured after injection of artificial cerebrospinal fluid vehicle, urocortin 1, corticotropin-releasing factor and the corticotropin-releasing factor type-2 receptor-selective antagonist antisauvagine-30 onto the dorsal raphe. Compared with vehicle, corticotropin-releasing factor and antisauvagine-30, urocortin 1 induced a significant reduction in the amount of food consumed overnight. Also, compared with antisauvagine-30 treatment, urocortin 1 significantly reduced the amount of weight gained during this time. Urocortin 1 also significantly reduced the total amount of fluid consumed, but did not alter ethanol preference, which was high during all treatments. These results suggest that the dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding, possibly through modulation of serotonergic activity from this nucleus. 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Urocortin 1 is a neuropeptide related to corticotropin-releasing factor that has high affinity for corticotropin-releasing factor type-1 and corticotropin-releasing factor type-2 receptors. In several mouse models, the amount of urocortin 1 neurons within the Edinger-Westphal nucleus is positively associated with ethanol preference. Central administration of urocortin 1 exerts potent anorectic actions, and implicates endogenous urocortin 1 in the regulation of food intake. It is possible that brain areas such as the dorsal raphe, which receives urocortin 1 from the Edinger-Westphal nucleus and highly expresses corticotropin-releasing factor type-2 receptors, mediate the actions of urocortin 1 on feeding and ethanol preference. In this study the amount of food, water and ethanol consumed over the dark cycle by ethanol-preferring C57BL/6J mice was measured after injection of artificial cerebrospinal fluid vehicle, urocortin 1, corticotropin-releasing factor and the corticotropin-releasing factor type-2 receptor-selective antagonist antisauvagine-30 onto the dorsal raphe. Compared with vehicle, corticotropin-releasing factor and antisauvagine-30, urocortin 1 induced a significant reduction in the amount of food consumed overnight. Also, compared with antisauvagine-30 treatment, urocortin 1 significantly reduced the amount of weight gained during this time. Urocortin 1 also significantly reduced the total amount of fluid consumed, but did not alter ethanol preference, which was high during all treatments. These results suggest that the dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding, possibly through modulation of serotonergic activity from this nucleus. In addition, it is suggested that endogenous urocortin 1 in this area, such as from the Edinger-Westphal nucleus, does not regulate ethanol preference in C57BL/6J mice.</description><subject>alcohol</subject><subject>Alcohol Drinking</subject><subject>Animals</subject><subject>Appetite - physiology</subject><subject>Biological and medical sciences</subject><subject>corticotropin</subject><subject>Corticotropin-Releasing Hormone - physiology</subject><subject>CRF</subject><subject>depression</subject><subject>Drinking Behavior - physiology</subject><subject>energy balance</subject><subject>Ethanol</subject><subject>Feeding Behavior - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microinjections</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacology</subject><subject>Raphe Nuclei - physiology</subject><subject>Rats</subject><subject>serotonin</subject><subject>Urocortins</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Weight Gain - physiology</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2PFCEQhonRuOPqXzDERE_2LJ8N403H70zixT0TBqpdJt0wC7SJ_14608l6lAOE1FNVbx6EXlGypYT2N6dthDmn4gJEB1tGiGyFLWH0EdpQrXinpBCP0YZw0ndCMnaFnpVyIu1IwZ-iK9pzronWG3R_m5NLuYaIKW5XvQPsUy52xNme2yfDr3m0FQoeUvLYRo-HcQ4euxTLPJ1rSPEtPs4Vx1Qx1Dsb04jPGQbIS7xl6F6qD4eb_juegoPn6MlgxwIv1vca3X7-9HP_tTv8-PJt__7QOUF07SyTTjsndwPTzDMCCgRTRB6dZNIOwnkFzvYEdkeuHbHc7zQnlBEFvqdO8Gv05jL3nNP9DKWaKRQH42gjpLkYRRSVQrMGvruArjktLbg55zDZ_MdQYhbh5mT-FW4W4UutCW_NL9ct83EC_9C6Gm7A6xWwxdlxyDa6UB44JXZSS964jxcOmpPfAbJZ1_mQwVXjU_ifPH8BOjilwg</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Weitemier, A.Z.</creator><creator>Ryabinin, A.E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice</title><author>Weitemier, A.Z. ; Ryabinin, A.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-a25c8cc59f282d20e7e42705bc525af4cd7eca60e9b38c0a3d98301207ed61c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>alcohol</topic><topic>Alcohol Drinking</topic><topic>Animals</topic><topic>Appetite - physiology</topic><topic>Biological and medical sciences</topic><topic>corticotropin</topic><topic>Corticotropin-Releasing Hormone - physiology</topic><topic>CRF</topic><topic>depression</topic><topic>Drinking Behavior - physiology</topic><topic>energy balance</topic><topic>Ethanol</topic><topic>Feeding Behavior - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microinjections</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacology</topic><topic>Raphe Nuclei - physiology</topic><topic>Rats</topic><topic>serotonin</topic><topic>Urocortins</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weitemier, A.Z.</creatorcontrib><creatorcontrib>Ryabinin, A.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weitemier, A.Z.</au><au>Ryabinin, A.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006</date><risdate>2006</risdate><volume>137</volume><issue>4</issue><spage>1439</spage><epage>1445</epage><pages>1439-1445</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The midbrain-localized Edinger-Westphal nucleus is a major site of production of urocortin 1. Urocortin 1 is a neuropeptide related to corticotropin-releasing factor that has high affinity for corticotropin-releasing factor type-1 and corticotropin-releasing factor type-2 receptors. In several mouse models, the amount of urocortin 1 neurons within the Edinger-Westphal nucleus is positively associated with ethanol preference. Central administration of urocortin 1 exerts potent anorectic actions, and implicates endogenous urocortin 1 in the regulation of food intake. It is possible that brain areas such as the dorsal raphe, which receives urocortin 1 from the Edinger-Westphal nucleus and highly expresses corticotropin-releasing factor type-2 receptors, mediate the actions of urocortin 1 on feeding and ethanol preference. In this study the amount of food, water and ethanol consumed over the dark cycle by ethanol-preferring C57BL/6J mice was measured after injection of artificial cerebrospinal fluid vehicle, urocortin 1, corticotropin-releasing factor and the corticotropin-releasing factor type-2 receptor-selective antagonist antisauvagine-30 onto the dorsal raphe. Compared with vehicle, corticotropin-releasing factor and antisauvagine-30, urocortin 1 induced a significant reduction in the amount of food consumed overnight. Also, compared with antisauvagine-30 treatment, urocortin 1 significantly reduced the amount of weight gained during this time. Urocortin 1 also significantly reduced the total amount of fluid consumed, but did not alter ethanol preference, which was high during all treatments. These results suggest that the dorsal raphe is a neuroanatomical substrate of urocortin 1-induced reductions in feeding, possibly through modulation of serotonergic activity from this nucleus. In addition, it is suggested that endogenous urocortin 1 in this area, such as from the Edinger-Westphal nucleus, does not regulate ethanol preference in C57BL/6J mice.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16338088</pmid><doi>10.1016/j.neuroscience.2005.10.021</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neuroscience, 2006, Vol.137 (4), p.1439-1445 |
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| subjects | alcohol Alcohol Drinking Animals Appetite - physiology Biological and medical sciences corticotropin Corticotropin-Releasing Hormone - physiology CRF depression Drinking Behavior - physiology energy balance Ethanol Feeding Behavior - physiology Fundamental and applied biological sciences. Psychology Humans Male Mice Mice, Inbred C57BL Microinjections Peptides - administration & dosage Peptides - pharmacology Raphe Nuclei - physiology Rats serotonin Urocortins Vertebrates: nervous system and sense organs Weight Gain - physiology |
| title | Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice |
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