Genetically Attenuated Plasmodium berghei Liver Stages Induce Sterile Protracted Protection That Is Mediated by Major Histocompatibility Complex Class I-Dependent Interferon-γ-Producing CD8+ T Cells

At present, radiation-attenuated plasmodia sporozoites (γ-spz) is the only vaccine that induces sterile and lasting protection in malaria-naive humans and laboratory rodents. However, γ-spz are not without risks. For example, the heterogeneity of the γ-spz could explain occasional breakthrough infec...

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Veröffentlicht in:	The Journal of infectious diseases 2007-08, Vol.196 (4), p.599-607
Hauptverfasser:	Jobe, Ousman, Lumsden, Joanne, Mueller, Ann-Kristin, Williams, Jackie, Silva-Rivera, Hilda, Kappe, Stefan H. I., Schwenk, Robert J., Matuschewski, Kai, Krzych, Urszula
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - genetics Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Drug Evaluation, Preclinical Female Gene Deletion Hepatocytes Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Human protozoal diseases Immunity Immunization Immunization Schedule Immunologic Memory Infectious diseases Interferon-gamma - biosynthesis Liver Liver - immunology Malaria Malaria - immunology Malaria - prevention & control Malaria Vaccines - administration & dosage Malaria Vaccines - genetics Medical genetics Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Parasites Parasitic diseases Plasmodium berghei - genetics Plasmodium berghei - growth & development Protozoal diseases Sporozoites Sporozoites - immunology T lymphocytes Transcriptional regulatory elements Vaccination Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics
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