LRRK2 G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews

To the Editor: Most cases of Parkinson's disease are considered sporadic and idiopathic, although there is evidence of familial aggregation, and several monogenic forms have been identified. 1 Recently, several pathogenic mutations in the highly conserved leucine-rich repeat kinase 2 gene ( LRR...

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Veröffentlicht in:	The New England journal of medicine 2006-01, Vol.354 (4), p.424-425
Hauptverfasser:	Klein, Christine, Risch, Neil, Ozelius, Laurie J, Bressman, Susan B, Henick, Brian, Soto-Valencia, Jeannie, Saunders-Pullman, Rachel, Hailpern, Susan M, Ohmann, Erin, Senthil, Geetha, Lipton, Richard B, Deligtisch, Amanda, Tagliati, Michele, Hunt, Ann L
Format:	Artikel
Sprache:	eng
Schlagworte:	Europe - ethnology Heterozygote Homozygote Humans Jews - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Mutation New York City Parkinson Disease - genetics Parkinson's disease Protein-Serine-Threonine Kinases - genetics
Online-Zugang:	Volltext
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