Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes
Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping f...
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| Veröffentlicht in: | British journal of nutrition 2007-08, Vol.98 (2), p.345-350 |
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| creator | Bene, Judit Komlósi, Katalin Magyari, Lili Talián, Gábor Horváth, Krisztina Gasztonyi, Beáta Miheller, Pál Figler, Mária Mózsik, Gyula Tulassay, Zsolt Melegh, Béla |
| description | Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl- (0·243 (sem 0·008) v. 0·283 (sem 0·014) μmol/l), butyryl- (0·274 (sem 0·009) v. 0·301 (sem 0·013)) and isovalerylcarnitine (0·147 (sem 0·006) v. 0·185 (sem 0·009)) levels were decreased; while the level of octenoyl- (0·086 (sem 0·006) v. 0·069 (sem 0·005)), myristoleyl- (0·048 (sem 0·003) v. 0·037 (sem 0·003)), palmitoyl- (0·140 (sem 0·005) v. 0·122 (sem 0·004)) and oleylcarnitine (0·172 (sem 0·006) v. 0·156 (sem 0·008); P |
| doi_str_mv | 10.1017/S0007114507705020 |
| format | Article |
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The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl- (0·243 (sem 0·008) v. 0·283 (sem 0·014) μmol/l), butyryl- (0·274 (sem 0·009) v. 0·301 (sem 0·013)) and isovalerylcarnitine (0·147 (sem 0·006) v. 0·185 (sem 0·009)) levels were decreased; while the level of octenoyl- (0·086 (sem 0·006) v. 0·069 (sem 0·005)), myristoleyl- (0·048 (sem 0·003) v. 0·037 (sem 0·003)), palmitoyl- (0·140 (sem 0·005) v. 0·122 (sem 0·004)) and oleylcarnitine (0·172 (sem 0·006) v. 0·156 (sem 0·008); P < 0·05 in all comparisons) were increased. After sorting the patients into SLC22A genotype-specific subgroups, no significant differences could be observed between them. The carnitine ester profile data suggest selective involvement of the carnitine esters in CD patients, probably due to their altered metabolism.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114507705020</identifier><identifier>PMID: 17391561</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; biomarkers ; blood chemistry ; carnitine ; Carnitine - analogs & derivatives ; Carnitine - blood ; Carnitine - genetics ; Carnitine ester profile ; Crohn disease ; Crohn Disease - blood ; Crohn Disease - genetics ; Crohn's disease ; Deoxyribonucleic acid ; Disease control ; disease resistance ; DNA ; epidemiology ; Esters ; Esters - blood ; etiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; gene expression ; Gene Frequency - genetics ; Genes ; Genetic factors ; genetic polymorphism ; Genetic Predisposition to Disease - genetics ; genetic variance ; Genotype ; Genotype & phenotype ; Genotypes ; Histology ; homeostasis ; human genetics ; Humans ; lipid metabolism ; Male ; Mass spectrometry ; Metabolic disorders ; Middle Aged ; molecular sequence data ; Mutation ; Nod2 Signaling Adaptor Protein - genetics ; NOD2/CARD15 ; nucleotide sequences ; OCTN1 ; OCTN2 ; Organic Cation Transport Proteins - genetics ; patients ; Plasma ; point mutation ; Proteins ; quantitative traits ; transporters ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2007-08, Vol.98 (2), p.345-350</ispartof><rights>Copyright © The Authors 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-f714b724365b091ead7042ed082cbafc4abf8cbf0e3b78800c513ce7f3c498d3</citedby><cites>FETCH-LOGICAL-c505t-f714b724365b091ead7042ed082cbafc4abf8cbf0e3b78800c513ce7f3c498d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114507705020/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18922911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17391561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bene, Judit</creatorcontrib><creatorcontrib>Komlósi, Katalin</creatorcontrib><creatorcontrib>Magyari, Lili</creatorcontrib><creatorcontrib>Talián, Gábor</creatorcontrib><creatorcontrib>Horváth, Krisztina</creatorcontrib><creatorcontrib>Gasztonyi, Beáta</creatorcontrib><creatorcontrib>Miheller, Pál</creatorcontrib><creatorcontrib>Figler, Mária</creatorcontrib><creatorcontrib>Mózsik, Gyula</creatorcontrib><creatorcontrib>Tulassay, Zsolt</creatorcontrib><creatorcontrib>Melegh, Béla</creatorcontrib><title>Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl- (0·243 (sem 0·008) v. 0·283 (sem 0·014) μmol/l), butyryl- (0·274 (sem 0·009) v. 0·301 (sem 0·013)) and isovalerylcarnitine (0·147 (sem 0·006) v. 0·185 (sem 0·009)) levels were decreased; while the level of octenoyl- (0·086 (sem 0·006) v. 0·069 (sem 0·005)), myristoleyl- (0·048 (sem 0·003) v. 0·037 (sem 0·003)), palmitoyl- (0·140 (sem 0·005) v. 0·122 (sem 0·004)) and oleylcarnitine (0·172 (sem 0·006) v. 0·156 (sem 0·008); P < 0·05 in all comparisons) were increased. After sorting the patients into SLC22A genotype-specific subgroups, no significant differences could be observed between them. The carnitine ester profile data suggest selective involvement of the carnitine esters in CD patients, probably due to their altered metabolism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>blood chemistry</subject><subject>carnitine</subject><subject>Carnitine - analogs & derivatives</subject><subject>Carnitine - blood</subject><subject>Carnitine - genetics</subject><subject>Carnitine ester profile</subject><subject>Crohn disease</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - genetics</subject><subject>Crohn's disease</subject><subject>Deoxyribonucleic acid</subject><subject>Disease control</subject><subject>disease resistance</subject><subject>DNA</subject><subject>epidemiology</subject><subject>Esters</subject><subject>Esters - blood</subject><subject>etiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene expression</subject><subject>Gene Frequency - genetics</subject><subject>Genes</subject><subject>Genetic factors</subject><subject>genetic polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>genetic variance</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Histology</subject><subject>homeostasis</subject><subject>human genetics</subject><subject>Humans</subject><subject>lipid metabolism</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>molecular sequence data</subject><subject>Mutation</subject><subject>Nod2 Signaling Adaptor Protein - genetics</subject><subject>NOD2/CARD15</subject><subject>nucleotide sequences</subject><subject>OCTN1</subject><subject>OCTN2</subject><subject>Organic Cation Transport Proteins - genetics</subject><subject>patients</subject><subject>Plasma</subject><subject>point mutation</subject><subject>Proteins</subject><subject>quantitative traits</subject><subject>transporters</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kkGP0zAQhS0EYsvCD-ACFhJwCoztOE6OS2ALohKglrM1ceyulzQpdipRfj0OjagE4mTZ75sZPz8T8pjBKwZMvV4DgGIsl6AUSOBwhyxYrmTGi4LfJYtJzib9gjyI8TZtSwbVfXLBlKiYLNiCHD93GHdIDYbej7631MbRBroPg_OdjdT3tA7DTf8y0tZHi9HSPY7e9mOk5gYDmoT7n7albgh0vao5v8ppzQrFNxT7dj6SdJlxUDXd2n4Yj3sbH5J7DrtoH83rJdlcv9vU77PVp-WH-mqVGQlyzJxieaN4LgrZQMUstgpyblsouWnQmRwbV5rGgRWNKksAI5kwVjlh8qpsxSV5cWqbHH0_JHN656OxXYe9HQ5Rq_SCnDOZwGd_gbfDIfTpapozUQrgVZkgdoJMGGIM1ul98DsMR81AT5nofzJJNU_mxodmZ9tzxRxCAp7PAEaDnQvYGx_PXFlxXrGJy06cTxH9-KNj-KYLJZTUxfKLLq9Xb9-I9Uc9DX564h0OGrch9fy65sBE-gcgit92xGwHd03w7daeTf_f0C-5Jbe7</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Bene, Judit</creator><creator>Komlósi, Katalin</creator><creator>Magyari, Lili</creator><creator>Talián, Gábor</creator><creator>Horváth, Krisztina</creator><creator>Gasztonyi, Beáta</creator><creator>Miheller, Pál</creator><creator>Figler, Mária</creator><creator>Mózsik, Gyula</creator><creator>Tulassay, Zsolt</creator><creator>Melegh, Béla</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes</title><author>Bene, Judit ; Komlósi, Katalin ; Magyari, Lili ; Talián, Gábor ; Horváth, Krisztina ; Gasztonyi, Beáta ; Miheller, Pál ; Figler, Mária ; Mózsik, Gyula ; Tulassay, Zsolt ; Melegh, Béla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-f714b724365b091ead7042ed082cbafc4abf8cbf0e3b78800c513ce7f3c498d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>blood chemistry</topic><topic>carnitine</topic><topic>Carnitine - analogs & derivatives</topic><topic>Carnitine - blood</topic><topic>Carnitine - genetics</topic><topic>Carnitine ester profile</topic><topic>Crohn disease</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - genetics</topic><topic>Crohn's disease</topic><topic>Deoxyribonucleic acid</topic><topic>Disease control</topic><topic>disease resistance</topic><topic>DNA</topic><topic>epidemiology</topic><topic>Esters</topic><topic>Esters - blood</topic><topic>etiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene expression</topic><topic>Gene Frequency - genetics</topic><topic>Genes</topic><topic>Genetic factors</topic><topic>genetic polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>genetic variance</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Histology</topic><topic>homeostasis</topic><topic>human genetics</topic><topic>Humans</topic><topic>lipid metabolism</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Metabolic disorders</topic><topic>Middle Aged</topic><topic>molecular sequence data</topic><topic>Mutation</topic><topic>Nod2 Signaling Adaptor Protein - genetics</topic><topic>NOD2/CARD15</topic><topic>nucleotide sequences</topic><topic>OCTN1</topic><topic>OCTN2</topic><topic>Organic Cation Transport Proteins - genetics</topic><topic>patients</topic><topic>Plasma</topic><topic>point mutation</topic><topic>Proteins</topic><topic>quantitative traits</topic><topic>transporters</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bene, Judit</creatorcontrib><creatorcontrib>Komlósi, Katalin</creatorcontrib><creatorcontrib>Magyari, Lili</creatorcontrib><creatorcontrib>Talián, Gábor</creatorcontrib><creatorcontrib>Horváth, Krisztina</creatorcontrib><creatorcontrib>Gasztonyi, Beáta</creatorcontrib><creatorcontrib>Miheller, Pál</creatorcontrib><creatorcontrib>Figler, Mária</creatorcontrib><creatorcontrib>Mózsik, Gyula</creatorcontrib><creatorcontrib>Tulassay, Zsolt</creatorcontrib><creatorcontrib>Melegh, Béla</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bene, Judit</au><au>Komlósi, Katalin</au><au>Magyari, Lili</au><au>Talián, Gábor</au><au>Horváth, Krisztina</au><au>Gasztonyi, Beáta</au><au>Miheller, Pál</au><au>Figler, Mária</au><au>Mózsik, Gyula</au><au>Tulassay, Zsolt</au><au>Melegh, Béla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>98</volume><issue>2</issue><spage>345</spage><epage>350</epage><pages>345-350</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl- (0·243 (sem 0·008) v. 0·283 (sem 0·014) μmol/l), butyryl- (0·274 (sem 0·009) v. 0·301 (sem 0·013)) and isovalerylcarnitine (0·147 (sem 0·006) v. 0·185 (sem 0·009)) levels were decreased; while the level of octenoyl- (0·086 (sem 0·006) v. 0·069 (sem 0·005)), myristoleyl- (0·048 (sem 0·003) v. 0·037 (sem 0·003)), palmitoyl- (0·140 (sem 0·005) v. 0·122 (sem 0·004)) and oleylcarnitine (0·172 (sem 0·006) v. 0·156 (sem 0·008); P < 0·05 in all comparisons) were increased. After sorting the patients into SLC22A genotype-specific subgroups, no significant differences could be observed between them. The carnitine ester profile data suggest selective involvement of the carnitine esters in CD patients, probably due to their altered metabolism.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>17391561</pmid><doi>10.1017/S0007114507705020</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 2007-08, Vol.98 (2), p.345-350 |
| issn | 0007-1145 1475-2662 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences biomarkers blood chemistry carnitine Carnitine - analogs & derivatives Carnitine - blood Carnitine - genetics Carnitine ester profile Crohn disease Crohn Disease - blood Crohn Disease - genetics Crohn's disease Deoxyribonucleic acid Disease control disease resistance DNA epidemiology Esters Esters - blood etiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology gene expression Gene Frequency - genetics Genes Genetic factors genetic polymorphism Genetic Predisposition to Disease - genetics genetic variance Genotype Genotype & phenotype Genotypes Histology homeostasis human genetics Humans lipid metabolism Male Mass spectrometry Metabolic disorders Middle Aged molecular sequence data Mutation Nod2 Signaling Adaptor Protein - genetics NOD2/CARD15 nucleotide sequences OCTN1 OCTN2 Organic Cation Transport Proteins - genetics patients Plasma point mutation Proteins quantitative traits transporters Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes |
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