Protein kinase Cε is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/cip1-dependent manner

The protein kinase C (PKC) family of proteins plays important roles in growth regulation and is implicated in tumorigenesis. It has become clear that the role of PKC in tumorigenesis is cell context dependent and/or isoform specific. In this study, we showed for the first time by immunohistochemistr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-07, Vol.67 (13), p.6053-6063
Hauptverfasser:	BAE, Kyung-Mi, HEIMAN WANG, GUOHUA JIANG, CHEN, Melissa G, LI LU, LEI XIAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell Proliferation Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Female Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Male Medical sciences Middle Aged Pharmacology. Drug treatments Pneumology Protein Kinase C-epsilon - biosynthesis Tumor Suppressor Protein p53 - metabolism Tumors Tumors of the respiratory system and mediastinum
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