Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems

A new class of surfactants with glycerate headgroups, that form viscous lyotropic liquid crystalline phases in excess water, have been investigated for their potential to provide sustained release matrices for depot drug delivery. Oleyl glycerate and phytanyl glycerate were used as representative su...

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Veröffentlicht in:	International journal of pharmaceutics 2006-02, Vol.309 (1), p.218-226
Hauptverfasser:	Boyd, Ben J., Whittaker, Darryl V., Khoo, Shui-Mei, Davey, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Biological and medical sciences Camptothecin - analogs & derivatives Camptothecin - chemistry Cubic phase Delayed-Action Preparations General pharmacology Glycerate surfactant Glyceric Acids - chemistry Glycerides - chemistry Hexagonal phase In vitro release Kinetics Liquid Crystals Medical sciences Octreotide - chemistry Paclitaxel - chemistry Parenteral depot formulations Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility Surface-Active Agents - chemistry Water - chemistry
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