Inclusion complexes of pyrimethamine in 2-hydroxypropyl-β-cyclodextrin: Characterization, phase solubility and molecular modelling

A 1:1 inclusion complex of pyrimethamine with hydroxypropyl β-cyclodextrin was prepared, characterized and modelled by AM1 method. Phase solubility and stoichiometry of the system were carried out by standard methods. The inclusion complexation of pyrimethamine in 2-hydroxypropyl-β-cyclodextrin has...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-09, Vol.15 (17), p.5752-5759
Hauptverfasser:	de Araújo, Márcia Valéria Gaspar, Vieira, Elze Kelly Barbosa, Lázaro, Gilderman Silva, de Souza Conegero, Leila, Ferreira, Odair Pastor, Almeida, Luı´s Eduardo, Barreto, Ledjane Silva, da Costa, Nivan Bezerra, Gimenez, Iara F.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin 2-Hydroxypropyl-β-cyclodextrin Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents beta-Cyclodextrins - chemistry Biological and medical sciences Calorimetry, Differential Scanning Inclusion complex Medical sciences Models, Molecular Molecular Structure Pharmacology. Drug treatments Pyrimethamine Pyrimethamine - chemistry Solubility Spectrophotometry Thermogravimetry Toxoplasmosis X-Ray Diffraction
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