Effects of sevoflurane on the cAMP-induced short-circuit current in mouse tracheal epithelium and recombinant Cl− (CFTR) and K+ (KCNQ1) channels

An optimal level of airway surface liquid is essential for mucociliary clearance in lungs. The cAMP-activated cystic fibrosis transmembrane conductance regulator (CFTR) and KCNQ1 channels in tracheal epithelium play key roles in luminal and basolateral membranes, respectively. The aim of this study...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2007-08, Vol.99 (2), p.245-251
Hauptverfasser:	Kim, J.K., Yoo, H.Y., Kim, S.J., Hwang, Y.-S., Han, J., Kim, J.A., Kim, C.S., Cho, H.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	anaesthetic volatile anaesthetic volatile, sevoflurane Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - pharmacology Animals Biological and medical sciences Cells, Cultured Chlorides - metabolism Cyclic AMP - pharmacology Cystic Fibrosis Transmembrane Conductance Regulator - drug effects Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Diffusion Chambers, Culture Female ion channels ions ions, ion channels KCNQ1 Potassium Channel - antagonists & inhibitors KCNQ1 Potassium Channel - metabolism lung lung, trachea Male Medical sciences Methyl Ethers - pharmacology Mice Patch-Clamp Techniques Potassium Channel Blockers - pharmacology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism sevoflurane trachea Trachea - drug effects Trachea - metabolism
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